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01-09-2005 | Experimental

Two-dimensional and three-dimensional oxygen mapping by ³He-MRI validation in a lung phantom

Authors: Klaus Kurt Gast, Wolfgang G. Schreiber, Annette Herweling, Frank Lehmann, Gabor Erdös, Joerg Schmiedeskamp, Hans-Ulrich Kauczor, Balthasar Eberle

Published in: European Radiology | Issue 9/2005

Abstract

The aim of this study was to validate oxygen-sensitive ³He-MRI in noninvasive determination of the regional, two- and three-dimensional distribution of oxygen partial pressure. In a gas-filled elastic silicon ventilation bag used as a lung phantom, oxygen sensitive two- and three-dimensional ³He-MRI measurements were performed at different oxygen concentrations which had been equilibrated in a range of normal and pathologic values. The oxygen partial pressure distribution was determined from ³He-MRI using newly developed software allowing for mapping of oxygen partial pressure. The reference bulk oxygen partial pressure inside the phantom was measured by conventional respiratory gas analysis. In two-dimensional measurements, image-based and gas-analysis results correlated with r=0.98; in three-dimensional measurements the between-methods correlation coefficient was r=0.89. The signal-to-noise ratio of three-dimensional measurements was about half of that of two-dimensional measurements and became critical (below 3) in some data sets. Oxygen-sensitive ³He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces.

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Title: Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom
Authors: Klaus Kurt Gast
Wolfgang G. Schreiber
Annette Herweling
Frank Lehmann
Gabor Erdös
Joerg Schmiedeskamp
Hans-Ulrich Kauczor
Balthasar Eberle
Publication date: 01-09-2005
Publisher: Springer-Verlag
Published in: European Radiology / Issue 9/2005
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-005-2778-x

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Two-dimensional and three-dimensional oxygen mapping by ³He-MRI validation in a lung phantom

Abstract

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