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01-04-2012 | Case Report

Two Cases of Low-Grade Endometriod Carcinoma Associated with Undifferentiated Carcinoma of the Uterus (Dedifferentiated Carcinoma): A Molecular Study

Authors: Giovanna Giordano, Tiziana D’Adda, Lorena Bottarelli, Mariano Lombardi, Francesca Brigati, Roberto Berretta, Carla Merisio

Published in: Pathology & Oncology Research | Issue 2/2012

Abstract

Dedifferentiated carcinoma (DC) is an uterine neoplasm containing both low-grade endometrioid carcinoma (LGEC) and undifferentiated carcinoma (UC). DC is an aggressive tumour even when the UC component represents only 20% of the entire neoplasm. In this paper, two cases DCs at different stages of development, in 61- and 83-year-old women respectively were reported. In addition, in these uterine malignancies microsatellite instability (MSI) and loss of heterozygosity (LOH) were investigated in order to explain its aggressive behavior, in both components. Case #1 presented metastases at diagnosis, while case #2 was at a lower stage. LGEC component was invasive in case #1 and intramucous in case #2. In both cases, UC components were characterized by a high degree of instability, in accordance of its aggressive behaviour and its architectural heterogeneity. Further studies with more numerous cases are mandatory to confirm these data.

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Title: Two Cases of Low-Grade Endometriod Carcinoma Associated with Undifferentiated Carcinoma of the Uterus (Dedifferentiated Carcinoma): A Molecular Study
Authors: Giovanna Giordano
Tiziana D’Adda
Lorena Bottarelli
Mariano Lombardi
Francesca Brigati
Roberto Berretta
Carla Merisio
Publication date: 01-04-2012
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 2/2012
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-011-9386-7

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