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01-07-2017 | Brief Communication

Tumor treating fields in pediatric high-grade glioma

Authors: Adam L. Green, Jean M. Mulcahy Levy, Rajeev Vibhakar, Molly Hemenway, Jennifer Madden, Nicholas Foreman, Kathleen Dorris

Published in: Child's Nervous System | Issue 7/2017

Abstract

Purpose

Tumor treating fields (TTF) are alternating electric fields applied continuously to the scalp. The treatment is approved for both primary and recurrent supratentorial adult glioblastoma but unstudied in children.

Methods

We report a feasibility case series of five pediatric high-grade glioma patients (ages 10–20 years) treated at our institution with TTF along with chemotherapy and/or radiation.

Results

Two patients began therapy at second recurrence and showed progressive disease. Two others were treated upfront after radiation therapy, and both showed partial responses. A fifth patient was treated at first recurrence and also showed a partial response. All five tolerated TTF well without treatment-limiting toxicities.

Conclusions

The tolerability of TTF, combined with the adult data, justify a pediatric clinical trial.

Mehta M, Wen P, Nishikawa R, Reardon D, Peters K (2017) Critical review of the addition of tumor treating fields (TTFields) to the existing standard of care for newly diagnosed glioblastoma patients. Crit Rev Oncol Hematol 111:60–65. doi:10.1016/j.critrevonc.2017.01.005 CrossRefPubMed

Fangusaro J (2009) Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas. J Child Neurol 24(11):1409–1417. doi:10.1177/0883073809338960 CrossRefPubMed

Wong ET, Toms SA, Ahluwalia MS (2015) Technological advances in the treatment of cancer: combining modalities to optimize outcomes. Clinical advances in hematology & oncology : H&O 13(11 Suppl 11):1–18

Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA et al (2015) Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial. JAMA 314(23):2535–2543. doi:10.1001/jama.2015.16669 CrossRefPubMed

Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V et al (2012) NovoTTF-100A versus physician's choice chemotherapy in recurrent glioblastoma: a randomised phase III trial of a novel treatment modality. Eur J Cancer 48(14):2192–2202. doi:10.1016/j.ejca.2012.04.011 CrossRefPubMed

O'Connell D, Shen V, Loudon W, Bota DA (2017) First report of tumor treating fields use in combination with bevacizumab in a pediatric patient: a case report. CNS oncology 6(1):11–18. doi:10.2217/cns-2016-0018 CrossRefPubMed

Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y et al (2014) The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet 46(5):444–450. doi:10.1038/ng.2938 CrossRefPubMedPubMedCentral

Fangusaro J (2012) Pediatric high grade glioma: a review and update on tumor clinical characteristics and biology. Front Oncol 2:105. doi:10.3389/fonc.2012.00105 CrossRefPubMedPubMedCentral

Title: Tumor treating fields in pediatric high-grade glioma
Authors: Adam L. Green
Jean M. Mulcahy Levy
Rajeev Vibhakar
Molly Hemenway
Jennifer Madden
Nicholas Foreman
Kathleen Dorris
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Child's Nervous System / Issue 7/2017
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-017-3431-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor treating fields in pediatric high-grade glioma

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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