Skip to main content
Top
Published in: Head and Neck Pathology 4/2009

01-12-2009 | Case Report

Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature

Authors: Olga L. Bohn, Luis E. De las Casas, Marino E. Leon

Published in: Head and Neck Pathology | Issue 4/2009

Login to get access

Abstract

Metastatic disease to thyroid gland is a rare event. Although renal cell carcinoma (RCC) has been reported to metastasize the thyroid gland, metastatic RCC to a thyroid neoplasm is very unusual. We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented.
Literature
1.
go back to reference Shimaoka K, Sokal JE, Pickren JW. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer. 1962;15:557–65.CrossRefPubMed Shimaoka K, Sokal JE, Pickren JW. Metastatic neoplasms in the thyroid gland. Pathological and clinical findings. Cancer. 1962;15:557–65.CrossRefPubMed
2.
go back to reference Rizzo M, Rossi RT, Bonaffini O, et al. Thyroid metastasis of clear cell renal carcinoma: report of a case. Diagn Cytopathol. 2009. Rizzo M, Rossi RT, Bonaffini O, et al. Thyroid metastasis of clear cell renal carcinoma: report of a case. Diagn Cytopathol. 2009.
3.
go back to reference Lam KY, Lo CY. Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med. 1998;122(1):37–41.PubMed Lam KY, Lo CY. Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med. 1998;122(1):37–41.PubMed
4.
go back to reference Lin JD, Weng HF, Ho YS. Clinical and pathological characteristics of secondary thyroid cancer. Thyroid. 1998;8(2):149–53.CrossRefPubMed Lin JD, Weng HF, Ho YS. Clinical and pathological characteristics of secondary thyroid cancer. Thyroid. 1998;8(2):149–53.CrossRefPubMed
5.
go back to reference Haugen BR, Nawaz S, Cohn A, et al. Secondary malignancy of the thyroid gland: a case report and review of the literature. Thyroid. 1994;4(3):297–300.CrossRefPubMed Haugen BR, Nawaz S, Cohn A, et al. Secondary malignancy of the thyroid gland: a case report and review of the literature. Thyroid. 1994;4(3):297–300.CrossRefPubMed
6.
go back to reference Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer. 2002;95(9):1869–78.CrossRefPubMed Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer. 2002;95(9):1869–78.CrossRefPubMed
7.
go back to reference Green LK, Ro JY, Mackay B, Ayala AG, Luna MA. Renal cell carcinoma metastatic to the thyroid. Cancer. 1989;63(9):1810–5.CrossRefPubMed Green LK, Ro JY, Mackay B, Ayala AG, Luna MA. Renal cell carcinoma metastatic to the thyroid. Cancer. 1989;63(9):1810–5.CrossRefPubMed
8.
go back to reference Czech JM, Lichtor TR, Carney JA, van Heerden JA. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet. 1982;155(4):503–5.PubMed Czech JM, Lichtor TR, Carney JA, van Heerden JA. Neoplasms metastatic to the thyroid gland. Surg Gynecol Obstet. 1982;155(4):503–5.PubMed
9.
go back to reference Elliott RH Jr, Frantz VK. Metastatic carcinoma masquerading as primary thyroid cancer: a report of authors’ 14 cases. Ann Surg. 1960;151:551–61.CrossRefPubMed Elliott RH Jr, Frantz VK. Metastatic carcinoma masquerading as primary thyroid cancer: a report of authors’ 14 cases. Ann Surg. 1960;151:551–61.CrossRefPubMed
10.
go back to reference Ivy HK. Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clin Proc. 1984;59(12):856–9.PubMed Ivy HK. Cancer metastatic to the thyroid: a diagnostic problem. Mayo Clin Proc. 1984;59(12):856–9.PubMed
11.
go back to reference Carcangiu ML, Sibley RK, Rosai J. Clear cell change in primary thyroid tumors. A study of 38 cases. Am J Surg Pathol. 1985;9(10):705–22.CrossRefPubMed Carcangiu ML, Sibley RK, Rosai J. Clear cell change in primary thyroid tumors. A study of 38 cases. Am J Surg Pathol. 1985;9(10):705–22.CrossRefPubMed
12.
go back to reference Rosai J, Carcangiu ML, DeLellis R. Tumors of the thyroid gland. Washington, DC: Armed Forces Institute of Pathology; 1992. p. 289–96. Rosai J, Carcangiu ML, DeLellis R. Tumors of the thyroid gland. Washington, DC: Armed Forces Institute of Pathology; 1992. p. 289–96.
13.
go back to reference Ryska A, Cap J. Tumor-to-tumor metastasis of renal cell carcinoma into oncocytic carcinoma of the thyroid. Report of a case and review of the literature. Pathol Res Pract. 2003;199(2):101–6.PubMed Ryska A, Cap J. Tumor-to-tumor metastasis of renal cell carcinoma into oncocytic carcinoma of the thyroid. Report of a case and review of the literature. Pathol Res Pract. 2003;199(2):101–6.PubMed
14.
go back to reference Qian L, Pucci R, Castro CY, Eltorky MA. Renal cell carcinoma metastatic to Hurthle cell adenoma of thyroid. Ann Diagn Pathol. 2004;8(5):305–8.CrossRefPubMed Qian L, Pucci R, Castro CY, Eltorky MA. Renal cell carcinoma metastatic to Hurthle cell adenoma of thyroid. Ann Diagn Pathol. 2004;8(5):305–8.CrossRefPubMed
15.
go back to reference Koo HL, Jang J, Hong SJ, Shong Y, Gong G. Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report. Acta Cytol. 2004;48(1):64–8.PubMed Koo HL, Jang J, Hong SJ, Shong Y, Gong G. Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report. Acta Cytol. 2004;48(1):64–8.PubMed
16.
go back to reference Baloch ZW, LiVolsi VA. Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med. 1999;123(8):703–6.PubMed Baloch ZW, LiVolsi VA. Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med. 1999;123(8):703–6.PubMed
17.
go back to reference Wolf G, Aigner RM, Humer-Fuchs U, Schwarz T, Krippl P, Wehrschuetz M. Renal cell carcinoma metastasis in a microfollicular adenoma of the thyroid gland. Acta Med Austriaca. 2002;29(4):141–2.CrossRefPubMed Wolf G, Aigner RM, Humer-Fuchs U, Schwarz T, Krippl P, Wehrschuetz M. Renal cell carcinoma metastasis in a microfollicular adenoma of the thyroid gland. Acta Med Austriaca. 2002;29(4):141–2.CrossRefPubMed
18.
go back to reference Rabson SM, Stier PL, Baumgartner JC, Rosenbaum D. Metastasis of cancer to cancer. Am J Clin Pathol. 1954;24(5):572–9.PubMed Rabson SM, Stier PL, Baumgartner JC, Rosenbaum D. Metastasis of cancer to cancer. Am J Clin Pathol. 1954;24(5):572–9.PubMed
19.
go back to reference Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL. Metastases of cancer to cancer. Cancer. 1968;22(3):635–43.CrossRefPubMed Campbell LV Jr, Gilbert E, Chamberlain CR Jr, Watne AL. Metastases of cancer to cancer. Cancer. 1968;22(3):635–43.CrossRefPubMed
20.
21.
go back to reference Holland JM. Proceedings: cancer of the kidney–natural history and staging. Cancer. 1973;32(5):1030–42.CrossRefPubMed Holland JM. Proceedings: cancer of the kidney–natural history and staging. Cancer. 1973;32(5):1030–42.CrossRefPubMed
22.
go back to reference Nakhjavani MK, Gharib H, Goellner JR, van Heerden JA. Metastasis to the thyroid gland. A report of 43 cases. Cancer. 1997;79(3):574–8.CrossRefPubMed Nakhjavani MK, Gharib H, Goellner JR, van Heerden JA. Metastasis to the thyroid gland. A report of 43 cases. Cancer. 1997;79(3):574–8.CrossRefPubMed
23.
go back to reference Wada N, Hirakawa S, Rino Y, et al. Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. Surg Today. 2005;35(6):483–7.CrossRefPubMed Wada N, Hirakawa S, Rino Y, et al. Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. Surg Today. 2005;35(6):483–7.CrossRefPubMed
24.
go back to reference Iesalnieks I, Trupka A, Raab M, et al. Renal cell carcinoma metastases to the thyroid gland-8 cases reported. Thyroid. 2007;17(1):49–52.CrossRefPubMed Iesalnieks I, Trupka A, Raab M, et al. Renal cell carcinoma metastases to the thyroid gland-8 cases reported. Thyroid. 2007;17(1):49–52.CrossRefPubMed
25.
go back to reference Hadjadj S, Geoffrois L, Aubert V, Weryha G, Leclere J. Thyroid metastases from cancer of the kidney. Two cases. Presse Med. 1995;24(30):1386–8.PubMed Hadjadj S, Geoffrois L, Aubert V, Weryha G, Leclere J. Thyroid metastases from cancer of the kidney. Two cases. Presse Med. 1995;24(30):1386–8.PubMed
26.
go back to reference Watts NB. Carcinoma metastatic to the thyroid: prevalence and diagnosis by fine-needle aspiration cytology. Am J Med Sci. 1987;293(1):13–7.CrossRefPubMed Watts NB. Carcinoma metastatic to the thyroid: prevalence and diagnosis by fine-needle aspiration cytology. Am J Med Sci. 1987;293(1):13–7.CrossRefPubMed
27.
go back to reference Schroder S, Bocker W. Clear-cell carcinomas of thyroid gland: a clinicopathological study of 13 cases. Histopathology. 1986;10(1):75–89.CrossRefPubMed Schroder S, Bocker W. Clear-cell carcinomas of thyroid gland: a clinicopathological study of 13 cases. Histopathology. 1986;10(1):75–89.CrossRefPubMed
Metadata
Title
Tumor-to-Tumor Metastasis: Renal Cell Carcinoma Metastatic to Papillary Carcinoma of Thyroid—Report of a Case and Review of the Literature
Authors
Olga L. Bohn
Luis E. De las Casas
Marino E. Leon
Publication date
01-12-2009
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 4/2009
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-009-0147-9

Other articles of this Issue 4/2009

Head and Neck Pathology 4/2009 Go to the issue

63rd Annual Meeting of the American Academy of Oral and Maxillofacial Pathology

Clinico-Pathologic Conference: Case 1

63rd Annual Meeting of the American Academy of Oral and Maxillofacial Pathology

Clinico-Pathologic Conference: Case 4