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European Archives of Oto-Rhino-Laryngology

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06-01-2024 | Review Article

Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan

Authors: Giuseppe Fancello, Virginia Fancello, Diana Ehsani, Vincenzo Porpiglia, Gianluca Piras, Antonio Caruso, Mario Sanna

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2024

Abstract

Introduction

Tympanojugular paragangliomas (TJ PGLs) are rare tumors characterized by bone infiltration and erosion and a close relationship with critical structures, such as cranial nerves and internal carotid artery. For these reasons, their management represents a tough challenge. Since the fifties, radio-therapy (RT) has been proposed as an alternative treatment aimed at avoiding tumor progression. However, the indolent nature of the tumor, characterized by slow growth, is a crucial factor that needs to be considered before offering radiation.

Methods

This study aims to examine tumor progression in RT patients through a systematic review of the literature and in TJ PGL patients who underwent solely wait and scan at our department.

Results

The rate of tumor progression in the RT group was 8.9%, while in the wait and scan cohort was 12.9%. This data suggests the innate slow growth of PGLs. However, it is not possible to draw certain conclusions because of the wide heterogeneity of the studies.

Conclusion

When complete surgical excision of TJ PGLs is not feasible, appropriate counseling and patient selection, including comprehensive tumor classification, should be performed before proposing RT to control tumor progression, since wait and scan may represent a reasonable option in selected cases.

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Title: Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan
Authors: Giuseppe Fancello
Virginia Fancello
Diana Ehsani
Vincenzo Porpiglia
Gianluca Piras
Antonio Caruso
Mario Sanna
Publication date: 06-01-2024
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 6/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08413-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor progression in tympanojugular paragangliomas: the role of radiotherapy and wait and scan

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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