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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2007

01-06-2007 | Review

Tumor metastasis to bone

Authors: Mandeep S Virk, Jay R Lieberman

Published in: Arthritis Research & Therapy | Special Issue 1/2007

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Abstract

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression. The receptor activator of nuclear factor-κB (RANK)/RANK ligand pathway has emerged as the key pathway regulating osteolysis in skeletal metastasis. A number of candidate factors, including the Wnt (wingless int) proteins, endothelin-1, and bone morphogenetic proteins, have been implicated in the establishment of osteoblastic metastasis. The complex nature of tumor-bone microenvironment interactions and the presence of multiple pathways that lead to bone metastasis suggests that simultaneous targeting of these pathways in the metastatic cascade are required for effective treatment. This review discusses current understanding of the pathophysiologic mechanisms that underlie the establishment of bone metastasis and potential molecular therapeutic strategies for prevention and treatment of bone metastasis.
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Metadata
Title
Tumor metastasis to bone
Authors
Mandeep S Virk
Jay R Lieberman
Publication date
01-06-2007
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2169

Other articles of this Special Issue 1/2007

Arthritis Research & Therapy 1/2007 Go to the issue

Review

Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies

Review

Erosive arthritis

Review

Clinical development of anti-RANKL therapy

Review

Role of RANKL inhibition in osteoporosis

Review

Multiple myeloma/hypercalcemia

Review

Biology of RANK, RANKL, and osteoprotegerin
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Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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