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Open Access 01-12-2012 | Research

Tumor growth effects of rapamycin on human biliary tract cancer cells

Authors: Matthias Heuer, Nici M Dreger, Vito R Cicinnati, Christian Fingas, Benjamin Juntermanns, Andreas Paul, Gernot M Kaiser

Published in: European Journal of Medical Research | Issue 1/2012

Abstract

Background

Liver transplantation is an important treatment option for patients with liver-originated tumors including biliary tract carcinomas ( BTCs). Post-transplant tumor recurrence remains a limiting factor for long-term survival. The mammalian target of rapamycin-targeting immunosuppressive drug rapamycin could be helpful in lowering BTC recurrence rates. Therein, we investigated the antiproliferative effect of rapamycin on BTC cells and compared it with standard immunosuppressants.

Methods

We investigated two human BTC cell lines. We performed cell cycle and proliferation analyses after treatment with different doses of rapamycin and the standard immunosuppressants, cyclosporine A and tacrolimus.

Results

Rapamycin inhibited the growth of two BTC cell lines in vitro. By contrast, an increase in cell growth was observed among the cells treated with the standard immunosuppressants.

Conclusions

These results support the hypothesis that rapamycin inhibits BTC cell proliferation and thus might be the preferred immunosuppressant for patients after a liver transplantation because of BTC.

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Title: Tumor growth effects of rapamycin on human biliary tract cancer cells
Authors: Matthias Heuer
Nici M Dreger
Vito R Cicinnati
Christian Fingas
Benjamin Juntermanns
Andreas Paul
Gernot M Kaiser
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2012
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-17-20

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor growth effects of rapamycin on human biliary tract cancer cells

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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