Skip to main content
Top
Published in: Journal of Infection and Chemotherapy 3/2012

01-06-2012 | Case Report

Tuberculous hilar lymphadenopathy progressing after isoniazid administration

Author: Shuichi Yano

Published in: Journal of Infection and Chemotherapy | Issue 3/2012

Login to get access

Abstract

Right hilar lymphadenopathy was the only radiologic finding in an immunocompetent 19-year-old man with a positive whole blood interferon-γ enzyme-linked immunosorbent test (QuantiFERON-TB-2G). Because his initial treating physician did not notice the lung lesion on chest radiography, isoniazid (INH) monotherapy was begun with subsequent progression of the lymphadenopathy. We must take into consideration even hilar lymphadenopathy in patients with tuberculosis (TB) disease without detectable Mycobacterium (M.) tuberculosis organisms, because INH monotherapy may result in progression of the TB lesion.
Literature
1.
go back to reference Mc Adams HP. Radiologic manifestations of pulmonary tuberculosis. Radiol Clin North Am. 1995;33:655–75. Mc Adams HP. Radiologic manifestations of pulmonary tuberculosis. Radiol Clin North Am. 1995;33:655–75.
2.
go back to reference Mona R, William B. Tuberculosis in children. In: William NR, Stuart MG, editors. Tuberculosis. 2nd ed. USA: Lippincott Williams & Wilkins; 2004. p. 615–6. Mona R, William B. Tuberculosis in children. In: William NR, Stuart MG, editors. Tuberculosis. 2nd ed. USA: Lippincott Williams & Wilkins; 2004. p. 615–6.
3.
go back to reference Stanberry SD. Tuberculosis in infants and children. J Thorac Imaging. 1990;5:17–27.CrossRef Stanberry SD. Tuberculosis in infants and children. J Thorac Imaging. 1990;5:17–27.CrossRef
4.
go back to reference Leung AN. Primary tuberculosis in childhood: radiographic manifestations. Radiology. 1992;182:87–91.PubMed Leung AN. Primary tuberculosis in childhood: radiographic manifestations. Radiology. 1992;182:87–91.PubMed
5.
go back to reference Mazurek GH, Lobue P, Iademarco MF, Metchock B, Vernon A. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR. 2005;54(RR15):49–55.PubMed Mazurek GH, Lobue P, Iademarco MF, Metchock B, Vernon A. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR. 2005;54(RR15):49–55.PubMed
6.
go back to reference Khan EA, Starke JR. Diagnosis of tuberculosis in children. Increased need for better methods. Emerg Infect Dis. 1995;1:115.PubMedCrossRef Khan EA, Starke JR. Diagnosis of tuberculosis in children. Increased need for better methods. Emerg Infect Dis. 1995;1:115.PubMedCrossRef
7.
go back to reference Jeffrey RS. Tuberculosis in infants and children. In: Schlossberg D, editor. Tuberculosis and nontuberculous mycobacterial infections. 5th edn. USA: WB Saunders Company; 2006. p. 365. Jeffrey RS. Tuberculosis in infants and children. In: Schlossberg D, editor. Tuberculosis and nontuberculous mycobacterial infections. 5th edn. USA: WB Saunders Company; 2006. p. 365.
8.
go back to reference Charles LD. Tuberculosis latency in humans. In: Schlossberg D, editor. Tuberculosis and nontuberculous mycobacterial infections. 5th edn. USA: WB Saunders Company; 2006. p. 86. Charles LD. Tuberculosis latency in humans. In: Schlossberg D, editor. Tuberculosis and nontuberculous mycobacterial infections. 5th edn. USA: WB Saunders Company; 2006. p. 86.
9.
go back to reference Donald PR, Sirgel FA, Venter A, Parkin DP, Seifart HI, van de Wal BW, Werely C, van Helden PD, Maritz JS. The influence of human N-acetyltransferase genotype on the early bacteriocidal activity of isoniazid. Clin Infect Dis. 2004;39:1425–30.PubMedCrossRef Donald PR, Sirgel FA, Venter A, Parkin DP, Seifart HI, van de Wal BW, Werely C, van Helden PD, Maritz JS. The influence of human N-acetyltransferase genotype on the early bacteriocidal activity of isoniazid. Clin Infect Dis. 2004;39:1425–30.PubMedCrossRef
10.
go back to reference Isoniazid. In: Kucers A, Crowe SM, Grayson MI. The use of antibiotics. 5th edn. Boston: Butterworth-Heineman; 1997. p. 1179-1210. Isoniazid. In: Kucers A, Crowe SM, Grayson MI. The use of antibiotics. 5th edn. Boston: Butterworth-Heineman; 1997. p. 1179-1210.
Metadata
Title
Tuberculous hilar lymphadenopathy progressing after isoniazid administration
Author
Shuichi Yano
Publication date
01-06-2012
Publisher
Springer Japan
Published in
Journal of Infection and Chemotherapy / Issue 3/2012
Print ISSN: 1341-321X
Electronic ISSN: 1437-7780
DOI
https://doi.org/10.1007/s10156-011-0328-9

Other articles of this Issue 3/2012

Journal of Infection and Chemotherapy 3/2012 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine