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01-09-2018 | Original Article

TSC gene expression in the newly diagnosed Egyptian acute leukemia patients

Authors: Hanaa Arnaout, Farida Gad Allah, Ola Khorshid, Zainab Elsaadany, Nevien Fouad, Maryam Amer

Published in: Comparative Clinical Pathology | Issue 5/2018

Abstract

TSC (tuberous sclerosis) complex is the major negative regulator of mTOR which activates cell cycle progression leading to uncontrolled growth. Acute leukemias are very heterogeneous as a group of hematological malignancies; they arise as a result of pled up genetic alterations. To study TSC gene expression in acute leukemia patients. Sixty-two Egyptian de no novo adult acute leukemia patients were assessed using SYBR green quantitative PCR as well as 22 controls. Correlation of TSC gene expression with response rate, other prognostic factors, and RFS was assessed. TSC1/TSC2 showed higher gene expression in acute leukemias compared to controls. TSC1 was significantly higher in T-ALL while TSC2 was significantly higher in B-ALL. Expression did not show significant correlation to known prognostic factors. TSC1/TSC2 overexpression might be implicated in the process of leukemogenesis.

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Title: TSC gene expression in the newly diagnosed Egyptian acute leukemia patients
Authors: Hanaa Arnaout
Farida Gad Allah
Ola Khorshid
Zainab Elsaadany
Nevien Fouad
Maryam Amer
Publication date: 01-09-2018
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-018-2722-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

TSC gene expression in the newly diagnosed Egyptian acute leukemia patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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