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Journal of Assisted Reproduction and Genetics

Published in:

01-11-2014 | Assisted Reproduction Technologies

Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population

Authors: Xiaojiao Chen, Junqiang Zhang, Xun Wu, Shanren Cao, Lin Zhou, Ying Wang, Xin Chen, Jin Lu, Chun Zhao, Minjian Chen, Xiufeng Ling

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2014

Abstract

Purpose

In this study, we estimated the effect of blastocoele expansion, ICM and TE quality after warming and culture on the rates of clinical pregnancy, live birth and miscarriage in vitrified-warmed single-blastocyst transfer cycle in a Chinese population.

Methods

A retrospective analysis of 263 cycles of vitrified-warmed single-blastocyst transfers was performed.

Results

The blastocysts with higher TE grade significantly increased the rates of clinical pregnancy (OR = 0.59, 95 % CI, 0.35–0.99, P = 0.045, grade (A + B) vs grade C) and live birth (OR = 0.55, 95 % CI, 0.32–0.94, P = 0.029, grade (A + B) vs grade C). And the association between TE grade and the rate of live birth didn’t change after the number of repeated cycles was adjusted (OR = 0.55, 95 % CI, 0.32–0.95, P = 0.033, grade (A + B) vs grade C). The number of repeated cycles was a confounding factor significantly different between the live birth and no live birth groups. By contrast, neither blastocoele expansion nor inner cell mass was statistically related to the rates of clinical pregnancy, live birth and miscarriage.

Conclusions

Our data firstly provided the evidence that TE grading, but not ICM grading, was significantly associated with the clinical pregnancy rate and live birth rate in vitrified-warmed blastocyst transfer cycles in a Chinese population. TE morphology may help predict outcomes of pregnancy in single-blastocyst transfer.

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Title: Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population
Authors: Xiaojiao Chen
Junqiang Zhang
Xun Wu
Shanren Cao
Lin Zhou
Ying Wang
Xin Chen
Jin Lu
Chun Zhao
Minjian Chen
Xiufeng Ling
Publication date: 01-11-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-014-0317-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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