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Pediatric Surgery International

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01-07-2021 | Trisomy 21 | Original Article

The risk factors for cholestasis in patients with duodenal atresia in a single institutional cohort

Authors: Chiyoshi Toyama, Kazunori Masahata, Souji Ibuka, Keigo Nara, Hideki Soh, Noriaki Usui

Published in: Pediatric Surgery International | Issue 7/2021

Abstract

Purpose

The etiology of cholestasis in neonates is associated with several factors including gastrointestinal disease and surgery. We aimed to identify the potential risk factors for perioperative cholestasis in patients with duodenal atresia and determine specific cutoff values for the risk factors.

Methods

This retrospective cohort study included 76 neonates diagnosed with duodenal atresia surgically treated during the neonatal period at our institution between January 1990 and March 2017. The neonates were categorized into two groups: those with and without cholestasis. Univariate and multivariate analyses were performed to identify the possible risk factors for cholestasis.

Results

Among the 76 neonates with duodenal atresia, 21 (27%) developed cholestasis. The duration of total parenteral nutrition was identified as a risk factor in univariate analysis; however, it was not an independent risk factor for cholestasis. Gestational age and highest C-reactive protein (CRP) values were independent risk factors, with adjusted odds ratios of 0.53 and 1.25, respectively. To predict the occurrence of cholestasis, the cutoff value for gestational age was 35.0 weeks, and highest CRP value was 2.4 mg/dL.

Conclusions

The occurrence of cholestasis in patients with duodenal atresia was associated with preterm delivery and severity of the inflammatory response during the perioperative period.

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Title: The risk factors for cholestasis in patients with duodenal atresia in a single institutional cohort
Authors: Chiyoshi Toyama
Kazunori Masahata
Souji Ibuka
Keigo Nara
Hideki Soh
Noriaki Usui
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Trisomy 21
Duodenal Atresia
Published in: Pediatric Surgery International / Issue 7/2021
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-021-04890-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The risk factors for cholestasis in patients with duodenal atresia in a single institutional cohort

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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