Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology
Published in: Skeletal Radiology 1/2016

01-01-2016 | Scientific Article

Triple-phase contrast-enhanced MRI for the prediction of preoperative chemotherapeutic effect in patients with osteosarcoma: comparison with 99mTc-MIBI scintigraphy

Authors: Hiroshi Wakabayashi, Junko Saito, Junichi Taki, Nanako Hashimoto, Hiroyuki Tsuchiya, Toshifumi Gabata, Seigo Kinuya

Published in: Skeletal Radiology | Issue 1/2016

Login to get access

Abstract

Objective

This study aims to determine whether 99mTc-MIBI scintigraphy and triple-phase contrast-enhanced magnetic resonance imaging (TCE-MRI) performed during and after preoperative chemotherapy have the power to predict final chemotherapeutic effects in patients with osteosarcoma (OS).

Materials and methods

Seventeen patients underwent 99mTc-MIBI scintigraphy and TCE-MRI before and after the middle and last courses of preoperative chemotherapy. As for 99mTc-MIBI scintigraphy, an uptake ratio (UR) and a reduction rate of UR (ΔURMIBI) were calculated. As for TCE-MRI, a ratio of contrast to background (CTB) was calculated in the whole tumor area (WA) at each phase on dynamic T1-weighted fat suppression images. Then a ratio of signal (R WA) was calculated by dividing CTB at triple-phase by CTB at pre-phase.

Results

Nine and eight patients showed good and poor response in histopathologic evaluation. The sensitivity, specificity, and accuracy for the prediction of histopathological chemotherapeutic effect was 44, 100, 69 % in R WA at the first phase, 100, 75, 88 % in ΔURMIBI after the middle course, 88, 100, 94 % in R WA at the first phase, and 100, 75, 88 % in ΔURMIBI after the last course of the preoperative chemotherapy, respectively.

Conclusion

Both 99mTc-MIBI scintigrapy and TCE-MRI can predict the tumor response in patients with OS after the completion of the preoperative chemotherapy.
Literature
1.
Hegyi M, Semsei AF, Jakab Z, Antal I, Kiss J, Szendroi M, et al. Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. Pediatr Blood Cancer. 2011;57(3):415–22.CrossRefPubMed
2.
Bielack S, Jürgens H, Jundt G, Kevric M, Kühne T, Reichardt P, et al. Osteosarcoma: the COSS experience. Cancer Treat Res. 2009;152:289–308.CrossRefPubMed
3.
Bielack SS, Carrle D, Hardes J, Schuck A, Paulussen M. Bone tumors in adolescents and young adults. Curt Treat Options Oncol. 2008;9(1):67–80.CrossRef
4.
Tsuchiya H, Tomita K, Mori Y, Asada N, Yamamoto N. Marginal excision for osteosarcoma with caffeine assisted chemotherapy. Clin Orthop Relat Res. 1999;358:27–35.PubMed
5.
Kimura H, Tsuchiya H, Shirai T, Nishida H, Hayashi K, Takeuchi A, et al. Caffeine-potentiated chemotherapy for metastatic osteosarcoma. J Orthop Sci. 2009;14(5):556–65.CrossRefPubMed
6.
Eftekhari F. Imaging assessment of osteosarcoma in childhood and adolescence: diagnosis, staging, and evaluating response to chemotherapy. Cancer Treat Res. 2009;152:33–62.CrossRefPubMed
7.
Fletcher BD. Response of osteosarcoma and Ewing sarcoma to chemotherapy: imaging evaluation. Am J Roentgenol. 1991;157(4):825–33.CrossRef
8.
Caldarella C, Salsano M, Isgrò MA, Treglia G. The role of fluorine-18-fluorodeoxyglucose positron emission tomography in assessing the response to neoadjuvant treatment in patients with osteosarcoma. Int J Mol Imaging. 2012;2012:870301.PubMedCentralPubMed
9.
Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K, et al. [18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in aggressive lymphoma: an early prognostic tool for predicting patient outcome. Blood. 2005;106(4):1376–81.CrossRefPubMed
10.
Berriolo-Riedinger A, Touzery C, Riedinger JM, Toubeau M, Coudert B, Arnould L, et al. [18F] FDG-PET predicts complete pathological response of breast cancer to neoadjuvant chemotherapy. Eur J Nucl Med Mol Imaging. 2007;34(12):1915–24.CrossRefPubMed
11.
Taki J, Inaki A, Wakabayashi H, Sumiya H, Tsuchiya H, Zen Y, et al. Early prediction of histopathological tumor response to preoperative chemotherapy by Tc-99m MIBI imaging in bone and soft tissue sarcomas. Clin Nucl Med. 2010;35(3):154–9.CrossRefPubMed
12.
Wakabayashi H, Taki J, Inaki A, Sumiya H, Zen Y, Tsuchiya H, et al. Prognostic value of 99mTc-MIBI scintigraphy performed during middle course of the preoperative chemotherapy in patients with malignant bone and soft tissue tumors. Clin Nucl Med. 2012;37(1):1–8.CrossRefPubMed
13.
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, et al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10(3):223–32.CrossRefPubMed
14.
van der Woude HJ, Bloem JL, Verstraete KL, Taminiau AH, Nooy MA, Hogendoorn PC. Osteosarcoma and Ewing’s sarcoma after neoadjuvant chemotherapy: value of dynamic MR imaging in detecting viable tumor before surgery. Am J Roentgenol. 1995;165(3):593–8.CrossRef
15.
Fletcher BD, Hanna SL, Fairclough DL, Gronemeyer SA. Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology. 1992;184(1):243–8.CrossRefPubMed
16.
Wang Y, Huang W, Panicek DM, Schwartz LH, Koutcher JA. Feasibility of using limited-population-based arterial input function for pharmacokinetic modeling of osteosarcoma dynamic contrast-enhanced MRI data. Magn Reson Med. 2008;59(5):1183–9.PubMedCentralCrossRefPubMed
17.
Reddick WE, Wang S, Xiong X, Glass JO, Wu S, Kaste SC, et al. Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma. Cancer. 2001;91(12):2230–7.CrossRefPubMed
18.
Rosen G, Marcove RC, Huvos AG, Caparros BI, Lane JM, Nirenberg A, et al. Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol. 1983;106:55–67.CrossRefPubMed
19.
Guo J, Reddick WE, Glass JO, Ji Q, Billups CA, Wu J, et al. Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma. Cancer. 2012;118(15):3776–85.PubMedCentralCrossRefPubMed
20.
Verstraete KL, Lang P. Bone and soft tissue tumors: the role of contrast agents for MR imaging. Eur J Radiol. 2000;34(3):229–46.CrossRefPubMed
21.
Ongolo-Zogo P, Thiesse P, Sau J, Desuzinges C, Blay JY, Bonmartin A, et al. Assessment of osteosarcoma response to neoadjuvant chemotherapy: comparative usefulness of dynamic gadolinium-enhanced spin-echo magnetic resonance imaging and technetium-99m skeletal angioscintigraphy. Eur Radiol. 1999;9(5):907–14.CrossRefPubMed
22.
Holscher HC, Bloem JL, van der Woude HJ, Hermans J, Nooy MA, Taminiau AH, et al. Can MRI predict the histopathological response in patients with osteosarcoma after the first cycle of chemotherapy? Clin Radiol. 1995;50(6):384–90.CrossRefPubMed
23.
Magnan H, Chou AJ, Chou JF, Yeung HW, Healey JH, Meyers PA. Noninvasive imaging with thallium-201 scintigraphy may not correlate with survival in patients with osteosarcoma. Cancer. 2010;116(17):4147–51.CrossRefPubMed
24.
Hamada K, Tomita Y, Inoue A, Fujimoto T, Hashimoto N, Myoui A, et al. Evaluation of chemotherapy response in osteosarcoma with FDG-PET. Ann Nucl Med. 2009;23(1):89–95.CrossRefPubMed
25.
Moore SG, Bisset 3rd GS, Siegel MJ, Donaldson JS. Pediatric musculoskeletal MR imaging. Radiology. 1991;179(2):345–60.CrossRefPubMed
26.
Taki J, Higuchi T, Sumiya H, Tsuchiya H, Minato H, Tomita K, et al. Prediction of final tumor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: comparison with Tl-201 imaging. J Orthop Res. 2008;26(3):411–8.CrossRefPubMed
27.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, et al. Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma. Eur J Nucl Med Mol Imaging. 2012;39(1):39–49.CrossRefPubMed
28.
Byun BH, Kong CB, Lim I, Kim BI, Choi CW, Song WS, et al. Early response monitoring to neoadjuvant chemotherapy in osteosarcoma using sequential 18F-FDG PET/CT and MRI. Eur J Nucl Med Mol Imaging. 2014;41(8):1553–62.CrossRefPubMed
Metadata
Title
Triple-phase contrast-enhanced MRI for the prediction of preoperative chemotherapeutic effect in patients with osteosarcoma: comparison with 99mTc-MIBI scintigraphy
Authors
Hiroshi Wakabayashi
Junko Saito
Junichi Taki
Nanako Hashimoto
Hiroyuki Tsuchiya
Toshifumi Gabata
Seigo Kinuya
Publication date
01-01-2016
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 1/2016
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-015-2250-1

Other articles of this Issue 1/2016

Skeletal Radiology 1/2016 Go to the issue

Scientific Article

Throwing-related injuries of the subscapularis in professional baseball players

Perspective

Problems with the pathological diagnosis of osteonecrosis

Scientific Article

No association between pseudotumors, high serum metal-ion levels and metal hypersensitivity in large-head metal-on-metal total hip arthroplasty at 5–7-year follow-up

Review Article

The femoral neck-shaft angle on plain radiographs: a systematic review

Scientific Article

Lumbar multifidus muscle changes in unilateral lumbar disc herniation using magnetic resonance imaging

Scientific Article

Intramuscular migration of calcium hydroxyapatite crystal deposits involving the rotator cuff tendons of the shoulder: report of 11 patients