Top

Journal of Medical Case Reports

Published in:

Open Access 01-12-2011 | Case report

Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature

Authors: Mohamed Mesmoudi, Saber Boutayeb, Tarik Mahfoud, Rachid Aasab, Nabil Ismaili, Meryem Glaoui, Hassan Errihani

Published in: Journal of Medical Case Reports | Issue 1/2011

Abstract

Introduction

The occurrence of multiple primary cancers is rare. Only a few cases and patient reviews of an association of triple malignancy have been reported.

Case presentation

We report here a case of a 78-year-old Moroccan woman presenting initially with a synchronous double malignancy, the first in her cervix and the second in her skin. Our patient was treated with radiation therapy for both tumors and remained in good control for 17 years, when she developed a metastatic disease from a neuroendocrine carcinoma of an unknown primary site.

Conclusions

Although the association of multiple primary cancers can be considered a rare occurrence, improving survival in cancer patients has made this situation more frequent.

Available only for authorised users

Spratt JR, Hoag MG: Incidence of multiple primary cancers per man-year of follow up: 20-year review from the Ellis Fischel State Cancer Hospital. Ann Surg. 1966, 164: 775-784. 10.1097/00000658-196611000-00001.CrossRefPubMedPubMedCentral

Curtis RE, Freedman DM, Ron E, Ries LAG, Hacker DG, Edwards BK, Tucker MA, Fraumeni JF: New malignancies among cancer survivors: SEER Cancer Registries, 1973-2000. 2006, National Cancer Institute. NIH Publ. No. 05-5302. Bethesda, MD

Howe HL, (Editor): A review of the definition for multiple primary cancers in the United States. Workshop Proceedings from December 4-6, 2002, in Princeton, New Jersey. 2003, Springfield (IL): North American Association of Central Cancer Registries

Agrawal A, Yau A, Magliocco A, Chu P: Cutaneous metastatic disease in cervical cancer: a case report. J Obstet Gynaecol Can. 2010, 32 (5): 467-CrossRefPubMed

Ozdemir H, Tunçbilek G: Metastasis of carcinoma of the uterine cervix to the nasal dorsum. J Craniofac Surg. 2009, 20 (3): 971-973. 10.1097/SCS.0b013e3181a2e430.CrossRefPubMed

Baykal C, Baykal Y, Taskiran C, Esinler I, Demirol A, Doğan R, Ayhan A: An extraordinary case of four primary tumors in the same patient, involving the uterine cervix, lung, skin, and rectum. Eur J Gynaecol Oncol. 2002, 23 (5): 451-452.PubMed

Corbalán-Vélez R, Ruiz-Maciá JA, Brufau C, Carapetod FJ: Cutaneous squamous cell carcicoma and human papillomavirus. Actas Dermosifiliogr. 2007, 98: 583-593. 10.1016/S0001-7310(07)70143-6.CrossRefPubMed

Levi F, Randimbison L, La Vecchia C: Nonmelanomatous skin cancer following cervical, vaginal, and vulvar neoplasms: etiologic association. J Natl Cancer Inst. 1998, 90 (20): 1570-1571. 10.1093/jnci/90.20.1570.CrossRefPubMed

Hennig EM, Di Lonardo A, Venuti A, Holm R, Marcante ML, Nesland JM: HPV 16 in multiple neoplastic lesions in women with CIN III. J Exp Clin Cancer Res. 1999, 18 (3): 369-377.PubMed

10.

Spigel DR, Hainsworth JD, Greco FA: Neuroendocrine carcinoma of unknown primary site. Semin Oncol. 2009, 36 (1): 52-59. 10.1053/j.seminoncol.2008.10.003.CrossRefPubMed

11.

Centeno BA: Pathology of liver metastases. Cancer Control. 2006, 13 (1): 13-26.PubMed

12.

Patel R, Adsay V, Andea A: Basal cell carcinoma with progression to metastatic neuroendocrine carcinoma. Rare Tumors. 2010, 2 (1): e8-PubMedPubMedCentral

13.

Koljonen V, Kukko H, Tukiainen E, Böhling T, Sankila R, Joensuu H, Pukkala E: Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study. Cancer Epidemiol. 2010, 34 (1): 62-65. 10.1016/j.canep.2009.12.007.CrossRefPubMed

14.

Feng H, Shuda M, Chang Y, Moore PS: Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008, 319 (5866): 1096-1100. 10.1126/science.1152586.CrossRefPubMedPubMedCentral

15.

Kassem A, Technau K, Kurz AK, Pantulu D, Löning M, Kayser G, Stickeler E, Weyers W, Diaz C, Werner M, Nashan D, Zur Hausen A: Merkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patients. Int J Cancer. 2009, 125 (2): 356-361. 10.1002/ijc.24323.CrossRefPubMed

16.

Rhiem K, Possover M, Gossmann A, Drebber K, Mallmann P, Ulrich U: "Occult" neuroendocrine component and rare metastatic pattern in cervical cancer: report of a case and brief review of the literature. Eur J Gynaecol Oncol. 2007, 28 (2): 139-141.PubMed

Title: Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature
Authors: Mohamed Mesmoudi
Saber Boutayeb
Tarik Mahfoud
Rachid Aasab
Nabil Ismaili
Meryem Glaoui
Hassan Errihani
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-5-462

At a glance: The STEP trials

Springer Medicine

Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature

Abstract

Introduction

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2011

Pseudotumor cerebri and ciprofloxacin: a case report

Laparoscopic myomectomy of a subserous pedunculated fibroid at 14 weeks of pregnancy: a case report

Ultrasound-guided thrombin injection for the treatment of an iatrogenic hepatic artery pseudoaneurysm: a case report

Rectal endometriosis causing colonic obstruction and concurrent endometriosis of the appendix: a case report

Low-pressure pulmonary artery aneurysm presenting with pulmonary embolism: a case series

Epstein Barr Virus-positive large T-cell lymphoma presenting as acute appendicitis 17 years after cadaveric renal transplant: a case report