Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Clinical Oral Investigations
Published in: Clinical Oral Investigations 1/2018

01-01-2018 | Original Article

Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey

Authors: Yu-Jin Kwon, Jeong-Won Park, Hyoung-Ji Lim, Yong-Jae Lee, Hye-Sun Lee, Jae-Yong Shim

Published in: Clinical Oral Investigations | Issue 1/2018

Login to get access

Abstract

Objectives

The aim of this study is to evaluate whether the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is associated with periodontal disease in Korean adults.

Materials and methods

This cross-sectional study included 12,249 individuals (4,941 men and 7,308 women) who took part in the 2012–2014 Korean National Health and Nutrition Examination Survey. We categorized the TG/HDL-C ratio into three groups. Periodontal disease was defined as a community pocket index score ≥3 with at least one affected site. Multiple logistic analyses were used to analyze the association between TG/HDL-C ratio and periodontal disease.

Results

In the study population, prevalence of periodontal disease was 31.6% in men and 21% in women. Compared to the lowest tertile group, OR (95% CI) of the highest tertile group for periodontal disease was 1.474 (1.220–1.780) in men and 1.259 (1.041–1.522) in women after adjusting for age, waist circumference, systolic blood pressure, fasting glucose, current smoking, alcohol drinking, physical activity, household income, oral health behavior, and use of anti-dyslipidemia medication.

Conclusion

Our study suggests that the TG/HDL-C ratio is associated with periodontal disease in Korean adults.

Clinical relevance

TG/HDL-C ratio is a simple and useful marker to reflect insulin resistance. And periodontal disease is also known to be related with insulin resistance. This study indicates that TG/HDL-C ratio was associated with periodontal disease in Korean adults.
Literature
1.
Eke PI, Dye BA, Wei L, Slade GD, Thornton-Evans GO, Borgnakke WS et al (2015) Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J Periodontol 86(5):611–622CrossRefPubMedPubMedCentral
2.
3.
Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M et al (2004) The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study. J Dent res 83(6):485–490CrossRefPubMed
4.
Saito T, Shimazaki Y, Koga T, Tsuzuki M, Ohshima A (2001) Relationship between upper body obesity and periodontitis. J Dent res 80(7):1631–1636CrossRefPubMed
5.
Lee JB, Yi HY, Bae KH (2013) The association between periodontitis and dyslipidemia based on the Fourth Korea National Health and Nutrition Examination Survey. J Clin Periodontol 40(5):437–442CrossRefPubMed
6.
Adiels M, Olofsson SO, Taskinen MR, Boren J (2008) Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 28(7):1225–1236CrossRefPubMed
7.
Murguia-Romero M, Jimenez-Flores JR, Sigrist-Flores SC, Espinoza-Camacho MA, Jimenez-Morales M, Pina E et al (2013) Plasma triglyceride/HDL-cholesterol ratio, insulin resistance, and cardiometabolic risk in young adults. J Lipid res 54(10):2795–2799CrossRefPubMedPubMedCentral
8.
Eeg-Olofsson K, Gudbjornsdottir S, Eliasson B, Zethelius B, Cederholm J (2014) The triglycerides-to-HDL-cholesterol ratio and cardiovascular disease risk in obese patients with type 2 diabetes: an observational study from the Swedish National Diabetes Register (NDR). Diabetes res Clin Pract 106(1):136–144CrossRefPubMed
9.
Turak O, Afsar B, Ozcan F, Oksuz F, Mendi MA, Yayla C et al (2015) The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict new cardiovascular events in essential hypertensive patients. J Clin Hypertens (Greenwich). doi:10.​1111/​jch.​12758
10.
McLaughlin T, Reaven G, Abbasi F, Lamendola C, Saad M, Waters D et al (2005) Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease? Am J Cardiol 96(3):399–404CrossRefPubMed
11.
Kim JS, Kang HT, Shim JY, Lee HR (2012) The association between the triglyceride to high-density lipoprotein cholesterol ratio with insulin resistance (HOMA-IR) in the general Korean population: based on the National Health and Nutrition Examination Survey in 2007-2009. Diabetes res Clin Pract 97(1):132–138CrossRefPubMed
12.
Jeppesen J, Hein HO, Suadicani P, Gyntelberg F (1997) Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease. An 8-year follow-up in the Copenhagen Male Study. Arterioscler Thromb Vasc Biol 17(6):1114–1120CrossRefPubMed
13.
14.
Li C, Ford ES, Meng YX, Mokdad AH, Reaven GM (2008) Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity? Cardiovasc Diabetol 7:4CrossRefPubMedPubMedCentral
15.
16.
Petersen PE, Ogawa H (2005) Strengthening the prevention of periodontal disease: the WHO approach. J Periodontol 76(12):2187–2193CrossRefPubMed
17.
World Health Organization (2013) Oral health surveys: basic methods, 5th edn. World Health Organization, Geneva
18.
Kim EJ, Jin BH, Bae KH (2011) Periodontitis and obesity: a study of the Fourth Korean National Health and Nutrition Examination Survey. J Periodontol 82(4):533–542CrossRefPubMed
19.
20.
Morita M, Horiuchi M, Kinoshita Y, Yamamoto T, Watanabe T (2004) Relationship between blood triglyceride levels and periodontal status. Community Dent Health 21(1):32–36PubMed
21.
Monteiro AM, Jardini MA, Alves S, Giampaoli V, Aubin EC, Figueiredo Neto AM et al (2009) Cardiovascular disease parameters in periodontitis. J Periodontol 80(3):378–388CrossRefPubMed
22.
Fentoglu O, Oz G, Tasdelen P, Uskun E, Aykac Y, Bozkurt FY (2009) Periodontal status in subjects with hyperlipidemia. J Periodontol 80(2):267–273CrossRefPubMed
23.
Pussinen PJ, Jauhiainen M, Vilkuna-Rautiainen T, Sundvall J, Vesanen M, Mattila K et al (2004) Periodontitis decreases the antiatherogenic potency of high density lipoprotein. J Lipid res 45(1):139–147CrossRefPubMed
24.
Katz J, Flugelman MY, Goldberg A, Heft M (2002) Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. J Periodontol 73(5):494–500CrossRefPubMed
25.
26.
Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ et al (1997) Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec cardiovascular study. Circulation 95(1):69–75CrossRefPubMed
27.
Borgnakke WS (2015) Does treatment of periodontal disease influence systemic disease? Dent Clin N am 59(4):885–917CrossRefPubMed
28.
Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71(10):1528–1534CrossRefPubMed
29.
Graves DT, Cochran D (2003) The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol 74(3):391–401CrossRefPubMed
30.
31.
32.
Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim BO, Nares S et al (1999) Association between periodontitis and hyperlipidemia: cause or effect? J Periodontol 70(12):1429–1434CrossRefPubMed
33.
Uchiumi D, Kobayashi M, Tachikawa T, Hasegawa K (2004) Subcutaneous and continuous administration of lipopolysaccharide increases serum levels of triglyceride and monocyte chemoattractant protein-1 in rats. J Periodontal res 39(2):120–128CrossRefPubMed
34.
Reardon MF, Sakai H, Steiner G (1982) Roles of lipoprotein lipase and hepatic triglyceride lipase in the catabolism in vivo of triglyceride-rich lipoproteins. Arteriosclerosis 2(5):396–402CrossRefPubMed
35.
Salazar MR, Carbajal HA, Espeche WG, Leiva Sisnieguez CE, March CE, Balbín E et al (2013) Comparison of the abilities of the plasma triglyceride/high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance. Diabetes and Vascular Disease Research 10(4):346–352CrossRefPubMed
36.
Li H-Y, Chen B-D, Ma Y-T, Yang Y-N, Ma X, Liu F et al (2016) Optimal cutoff of the triglyceride to high-density lipoprotein cholesterol ratio to detect cardiovascular risk factors among Han adults in Xinjiang. J Health Popul Nutr 35(1):30CrossRefPubMedPubMedCentral
Metadata
Title
Triglyceride to high density lipoprotein cholesterol ratio and its association with periodontal disease in Korean adults: findings based on the 2012–2014 Korean national health and nutrition examination survey
Authors
Yu-Jin Kwon
Jeong-Won Park
Hyoung-Ji Lim
Yong-Jae Lee
Hye-Sun Lee
Jae-Yong Shim
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 1/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-017-2140-0

Other articles of this Issue 1/2018

Clinical Oral Investigations 1/2018 Go to the issue

Erratum

Erratum to: clinical comparison of the effectiveness of 7- and 14-day intracanal medications in root canal disinfection and inflammatory cytokines

Original Article

Genome-wide gene expression profiling of tongue squamous cell carcinoma by RNA-seq

Erratum

Erratum to: comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws

Original Article

Influence of a face-bow on oral health-related quality of life after changing the vertical dimension in the articulator: a randomized controlled trial. Part II

Original Article

Effect of an oral healthcare programme on care staff knowledge and attitude regarding oral health: a non-randomised intervention trial

Original Article

Slow drilling speeds for single-drill implant bed preparation. Experimental in vitro study