Trichosporon inkin disseminated infection

Excerpt

During the treatment of an acute lymphoblastic leukemia, a 40-year-old man developed a fever and was admitted to the intensive care unit because of septic shock and respiratory failure. He presented with metastatic skin lesions (Fig. 1a), and a computed tomography found diffuse pulmonary micronodules (Fig. 1b). Two blood cultures grew on the fourth day and direct microscopic examination showed fungal hyphae (Fig. 2a). The culture of the skin punch identified arthroconidia and blastoconidia (Fig. 2b) suggesting Trichosporon species. Trichosporon inkin was identified by MALDI-TOF mass spectrometry in both samples and in pleural fluid. Fundoscopy revealed bilateral chorioretinitis, but transesophageal echocardiography did not find endocarditis. The patient received prolonged intravenous voriconazole, and his condition slowly improved.

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