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Intensive Care Medicine
Published in: Intensive Care Medicine 7/2015

01-07-2015 | Correspondence

Trials on stress ulcer prophylaxis: finding the balance between benefit and harm

Authors: Mette Krag, Anders Perner, Jørn Wetterslev, Matt P. Wise, Morten Hylander Møller

Published in: Intensive Care Medicine | Issue 7/2015

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Excerpt

Dear Editor, …
Literature
1.
Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Moller MH, SUP-ICU co-authors (2015) Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 41:833–845
2.
Deane AM, Guyatt GH (2015) Primum non nocere and challenging conventional treatment. Intensive Care Med 41:933–935
3.
Krag M, Perner A, Wetterslev J, Wise MP, Hylander Moller M (2014) Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40:11–22PubMedCrossRef
4.
Savovic J, Jones HE, Altman DG, Harris RJ, Juni P, Pildal J, Als-Nielsen B, Balk EM, Gluud C, Gluud LL, Ioannidis JP, Schulz KF, Beynon R, Welton NJ, Wood L, Moher D, Deeks JJ, Sterne JA (2012) Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med 157:429–438PubMedCrossRef
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Brok J, Thorlund K, Gluud C, Wetterslev J (2008) Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol 61:763–769PubMedCrossRef
Metadata
Title
Trials on stress ulcer prophylaxis: finding the balance between benefit and harm
Authors
Mette Krag
Anders Perner
Jørn Wetterslev
Matt P. Wise
Morten Hylander Møller
Publication date
01-07-2015
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2015
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-015-3860-8

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