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01-01-2016 | Original Article

Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family

Authors: Erlie Jiang, Jie Pan, Mingzhe Han, Liang Chen, Qiaoling Ma, Jialin Wei, Yong Huang, Sizhou Feng, Qin Sun, Peili Xiao, Zhongzheng Zheng

Published in: International Journal of Legal Medicine | Issue 1/2016

Abstract

Alleles at the D7S820 STR locus have 6–14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10–11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10–11 were a linked inheritance in this family.

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Title: Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family
Authors: Erlie Jiang
Jie Pan
Mingzhe Han
Liang Chen
Qiaoling Ma
Jialin Wei
Yong Huang
Sizhou Feng
Qin Sun
Peili Xiao
Zhongzheng Zheng
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Legal Medicine / Issue 1/2016
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-015-1166-6

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Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family

Abstract

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Abstract

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