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Open Access 01-12-2023 | Research

Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021

Authors: Boyong Wang, Qiaojie Wang, Musha Hamushan, Jinlong Yu, Feng Jiang, Mingzhang Li, Geyong Guo, Jin Tang, Pei Han, Hao Shen

Published in: BMC Infectious Diseases | Issue 1/2023

Abstract

Background

This study assessed the distribution characteristics of pathogens isolated from cases of orthopedic infections and focused on the antimicrobial susceptibility of the main pathogens.

Methods

This retrospective study involved patients with orthopedic infection in a tertiary medical center located in Shanghai, China, from 2008 to 2021.Pathogen information and the basic information of patients were identified from clinical microbiology laboratory data and the institutional medical record system.

Results

In total, the pathogen information of 2821 patients were enrolled in the study. S. aureus (37.71%) was the main causative pathogen responsible for orthopedic infection. Gender, pathogens distribution and polymicrobial infection rates were significantly different (P < 0.05) among patients with different orthopedic infection diseases.The trends in the distribution of pathogens in the total cohort, implant-related infection group (Group A), non-implant-related infection group (Group B), and the sub-group of cases with arthroplasty showed significant linear changes over time. And the polymicrobial infection rates of the total cohort (from 17.17% to 11.00%), Group B(from 24.35% to 14.47%), and the sub-group of cases with internal fixation (from 10.58% to 4.87%) decreased significantly. The antimicrobial susceptibility showed changing trends with time for some main pathogens, especially for S.aureus and Enterobacter spp.

Conclusions

Our research indicated that the pathogen distribution and antimicrobial susceptibility in orthopedic infections changed over time. And the distribution of pathogens varied significantly among different types of orthopedic infectious diseases. These findings may serve as a reference for prophylaxis and empirical treatment strategies of orthopedic infection.

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Title: Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021
Authors: Boyong Wang
Qiaojie Wang
Musha Hamushan
Jinlong Yu
Feng Jiang
Mingzhang Li
Geyong Guo
Jin Tang
Pei Han
Hao Shen
Publication date: 01-12-2023
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue 1/2023
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-023-08471-x

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Abstract

Background

Methods

Results

Conclusions

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