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01-09-2018 | Original Article

Trends in incidence and outcomes of gastroschisis in the United States: analysis of the national inpatient sample 2010–2014

Authors: Parth Bhatt, Anusha Lekshminarayanan, Keyur Donda, Fredrick Dapaah-Siakwan, Badal Thakkar, Sumesh Parat, Shilpi Chabra, Zeenia Billimoria

Published in: Pediatric Surgery International | Issue 9/2018

Abstract

Purpose

Gastroschisis is a severe congenital anomaly associated with a significant morbidity and mortality. There are limited temporal trend data on incidence, mortality, length of stay, and hospital cost of gastroschisis. Our aim was to study these temporal trends using the National Inpatient Sample (NIS).

Methods

We identified all neonatal admissions with a diagnosis of gastroschisis within the NIS from 2010 through 2014. We limited admission age to ≤ 28 days and excluded all those transferred to other hospitals. We estimated gastroschisis incidence, mortality, length of hospital stay, and cost of hospitalization. For continuous variables, trends were analyzed using survey regression. Cochrane–Armitage trend test was used to analyze trends for categorical variables. P < 0.05 was considered as significant.

Results

The incidence of gastroschisis increased from 4.5 to 4.9/10,000 live births from 2010 through 2014 (P = 0.01). Overall mortality was 3.5%, median length of stay was 35 days (95% CI 26–55 days), and median cost of hospitalization was $75,859 (95% CI $50,231–$122,000). After adjusting for covariates, there was no statistically significant change in mortality (OR = 1.13; 95% CI 0.87–1.48), LOS (β = − 2.1 ± 3.5; 95% CI − 9.0 to 4.8) and hospital cost (β = − 2.137 ± 10.813; 95% CI − 23,331 to 19,056) with each calendar year increase on multivariate logistic regression analysis.

Conclusion

The incidence of neonates with gastroschisis increased between 2010 and 2014. Incidence was highest in the West. No difference in mortality and resource utilization was observed.

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Title: Trends in incidence and outcomes of gastroschisis in the United States: analysis of the national inpatient sample 2010–2014
Authors: Parth Bhatt
Anusha Lekshminarayanan
Keyur Donda
Fredrick Dapaah-Siakwan
Badal Thakkar
Sumesh Parat
Shilpi Chabra
Zeenia Billimoria
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 9/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4308-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Trends in incidence and outcomes of gastroschisis in the United States: analysis of the national inpatient sample 2010–2014

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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