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Published in: BMC Geriatrics 1/2023

Open Access 01-12-2023 | Research

Trends in all-cause mortality and leading causes of death from 2009 to 2019 among older adults in China

Authors: Jian Wu, Zihan Mu, Shuai Jiang, Yudong Miao, Yanyu Tang, Jing Wang, Suxian Wang, Yaojun Zhao

Published in: BMC Geriatrics | Issue 1/2023

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Abstract

Background

This study aimed to determine long-term variations in mortality trends and identify the leading causes of death among older adults in China from 2009 to 2019 so as to propose interventions to further stabilise the mortality rate among older adults and facilitate healthy ageing.

Methods

We extracted data from the China Death Surveillance database from 2009 to 2019 for all-cause mortality and cause-specific death among individuals aged ≥ 65 years. A joinpoint regression model was used to estimate mortality trends by calculating the annual percentage change (APC). A trend chi-square test was used to estimate sex differences in mortality, and descriptive analysis was used to estimate the leading causes of death. Semi-structured expert interviews were conducted to examine health interventions for older adults.

Results

We observed an overall declining trend in age-adjusted mortality rates among older adults aged ≥ 65 years in China from 2009 to 2019 (APC, -2.44; P < 0.05). In this population, the male mortality rate was higher than the female mortality rate during this period (P < 0.05). However, the mortality rate among older adults aged ≥ 85 years increased since 2014, particularly among females. Cardiovascular disease (CVD) was the leading cause of death among older adults aged 65–84 years, whereas ischaemic heart disease was the leading cause of death among individuals aged ≥ 85 years, especially among females. The majority of injuries resulting in death were caused by falls, showing an increasing trend.

Conclusions

CVD is a major cause of death among older adults aged ≥ 65 years in China, and relevant health intervention strategies should be implemented from the perspectives of physiology, psychology, and living environment. The change in the mortality trend and the distribution of cause of death among older adults aged ≥ 85 years is noteworthy; a diagnostic and management model centred around females aged ≥ 85 years should be implemented. Additionally, a multidimensional fall prevention strategy involving primary medical institutions and care services needs to be implemented to reduce the risk of falls among older adults.
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Literature
1.
go back to reference Xiaojuan, He M et al. Basic and translational aging research in China: present and future. Protein Cell. 2019. Xiaojuan, He M et al. Basic and translational aging research in China: present and future. Protein Cell. 2019.
2.
go back to reference Bao J, Zhou L, Liu G, Tang J, Lu X, Cheng C, et al. Current state of care for the elderly in China in the context of an aging population. BioSci Trends. 2022;16:107–18.CrossRefPubMed Bao J, Zhou L, Liu G, Tang J, Lu X, Cheng C, et al. Current state of care for the elderly in China in the context of an aging population. BioSci Trends. 2022;16:107–18.CrossRefPubMed
3.
go back to reference Mitratza M, Kunst AE, Kardaun JWPF. Detecting mortality trends in the Netherlands Across 625 causes of death. Int J Environ Res Public Health. 2019;16. Mitratza M, Kunst AE, Kardaun JWPF. Detecting mortality trends in the Netherlands Across 625 causes of death. Int J Environ Res Public Health. 2019;16.
4.
go back to reference Yuta T, Masao I, Xueying J et al. National trends in the proportion of in-hospital deaths by cause of death among older adults with long-term care: a nationwide observational study in Japan from 2007 to 2017. BMC Geriatr. 2022;22. Yuta T, Masao I, Xueying J et al. National trends in the proportion of in-hospital deaths by cause of death among older adults with long-term care: a nationwide observational study in Japan from 2007 to 2017. BMC Geriatr. 2022;22.
5.
go back to reference Xiaoyao L, Keping C, Wei H et al. Implantable device measured objective daily physical activity as a predictor of long-term all-cause mortality and cardiac death in patients with age > 75 years and high risk of sudden cardiac death: a cohort study. BMC Geriatr. 2022;22. Xiaoyao L, Keping C, Wei H et al. Implantable device measured objective daily physical activity as a predictor of long-term all-cause mortality and cardiac death in patients with age > 75 years and high risk of sudden cardiac death: a cohort study. BMC Geriatr. 2022;22.
6.
go back to reference Xin C, Zhang B, Fang S, Zhou J. Daytime napping and successful aging among older adults in China: a cross-sectional study. BMC Geriatr. 2020;20. Xin C, Zhang B, Fang S, Zhou J. Daytime napping and successful aging among older adults in China: a cross-sectional study. BMC Geriatr. 2020;20.
7.
go back to reference Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, et al. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC Geriatr. 2020;20:261.CrossRefPubMedPubMedCentral Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, et al. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC Geriatr. 2020;20:261.CrossRefPubMedPubMedCentral
8.
go back to reference Chengbei H, Yinan L, Zimmer Z et al. Association of sleep duration with risk of all-cause mortality and poor quality of dying in oldest-old people: a community-based longitudinal study. BMC Geriatr. 2020;20. Chengbei H, Yinan L, Zimmer Z et al. Association of sleep duration with risk of all-cause mortality and poor quality of dying in oldest-old people: a community-based longitudinal study. BMC Geriatr. 2020;20.
9.
go back to reference Carioli G, Malvezzi M, Bertuccio P, Hashim D, Waxman S, Negri E et al. Cancer mortality in the elderly in 11 countries worldwide. 1970–2015.[J]. Annals of oncology: official journal of the european Society for Medical Oncology;2019:30(8). Carioli G, Malvezzi M, Bertuccio P, Hashim D, Waxman S, Negri E et al. Cancer mortality in the elderly in 11 countries worldwide. 1970–2015.[J]. Annals of oncology: official journal of the european Society for Medical Oncology;2019:30(8).
10.
go back to reference Martins MYC, Aparecida da Silva VM, Valverde de Oliveira VP, deJosé QS, Moreira PG, Silva SAC. E. Trend of fall-related mortality among the elderly. Rev Esc Enferm USP. 2021;55. Martins MYC, Aparecida da Silva VM, Valverde de Oliveira VP, deJosé QS, Moreira PG, Silva SAC. E. Trend of fall-related mortality among the elderly. Rev Esc Enferm USP. 2021;55.
11.
go back to reference Raúl LI, Tomás RA, Francisco BMJ, Raquel A et al. Risk models for predicting in-hospital mortality from COVID-19 pneumonia in the elderly. Emergencias rev Soc Esp Med Emergencias. 2021;33. Raúl LI, Tomás RA, Francisco BMJ, Raquel A et al. Risk models for predicting in-hospital mortality from COVID-19 pneumonia in the elderly. Emergencias rev Soc Esp Med Emergencias. 2021;33.
12.
go back to reference Liao R, Hu L, Liao Q, et al. Analysis of death causes of residents in poverty-stricken Areas in 2020: take Liangshan Yi Autonomous Prefecture in China as an example. BMC Public Health. 2022;22:1.CrossRef Liao R, Hu L, Liao Q, et al. Analysis of death causes of residents in poverty-stricken Areas in 2020: take Liangshan Yi Autonomous Prefecture in China as an example. BMC Public Health. 2022;22:1.CrossRef
13.
go back to reference Andrew F, Li-Hui et al. Major causes of injury death and the life expectancy gap between the United States and other high-income countries. JAMA. 2016. Andrew F, Li-Hui et al. Major causes of injury death and the life expectancy gap between the United States and other high-income countries. JAMA. 2016.
14.
go back to reference Xiaoshuang X, Wei Y, Baohua C, Mei L, Lei C, Lin W et al. Prevalence and risk factors of stroke in the elderly in Northern China: data from the National Stroke Screening Survey. J Neurol. 2019;266. Xiaoshuang X, Wei Y, Baohua C, Mei L, Lei C, Lin W et al. Prevalence and risk factors of stroke in the elderly in Northern China: data from the National Stroke Screening Survey. J Neurol. 2019;266.
15.
go back to reference Almigbal TH, Almutairi KM, Vinluan JM, Batais MA, Alodhayani A, Alonazi WB, et al. Gender differences in the impact of health literacy on hospital readmission among older heart failure patients: a prospective cohort study [J]. Saudi Med J. 2019;40:1158–66.CrossRefPubMedPubMedCentral Almigbal TH, Almutairi KM, Vinluan JM, Batais MA, Alodhayani A, Alonazi WB, et al. Gender differences in the impact of health literacy on hospital readmission among older heart failure patients: a prospective cohort study [J]. Saudi Med J. 2019;40:1158–66.CrossRefPubMedPubMedCentral
16.
go back to reference Li Y, Pan A, Wang DD et al. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018: CIRCULATIONAHA.117.032047;138:345–55. Li Y, Pan A, Wang DD et al. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018: CIRCULATIONAHA.117.032047;138:345–55.
17.
go back to reference Huang J, Zeng Q, Pan X, Guo X, Li G. Projections of the effects of global warming on the disease burden of ischemic heart disease in the elderly in Tianjin, China. BMC Public Health. 2019;19:1465.CrossRefPubMedPubMedCentral Huang J, Zeng Q, Pan X, Guo X, Li G. Projections of the effects of global warming on the disease burden of ischemic heart disease in the elderly in Tianjin, China. BMC Public Health. 2019;19:1465.CrossRefPubMedPubMedCentral
18.
go back to reference Waheed N, Kaufman N, Seawright J, Parrk K. Ischemic heart disease in women. Cardiovasc Innov Appl. 2019;3:305–15. Waheed N, Kaufman N, Seawright J, Parrk K. Ischemic heart disease in women. Cardiovasc Innov Appl. 2019;3:305–15.
19.
go back to reference Divoky L, Maran A, Ramu B. Gender differences in ischemic cardiomyopathy. Curr Atheroscler Rep. 2018;20:50.CrossRefPubMed Divoky L, Maran A, Ramu B. Gender differences in ischemic cardiomyopathy. Curr Atheroscler Rep. 2018;20:50.CrossRefPubMed
20.
go back to reference Severino P, D’Amato A, Pucci M, Infusino F, Adamo F, Birtolo LI, et al. Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction. Int J Mol Sci. 2020;21:8118.CrossRefPubMedPubMedCentral Severino P, D’Amato A, Pucci M, Infusino F, Adamo F, Birtolo LI, et al. Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction. Int J Mol Sci. 2020;21:8118.CrossRefPubMedPubMedCentral
21.
go back to reference Sirajuddin A, Mirmomen SM, Kligerman SJ, Groves DW, Burke AP, Kureshi F, et al. Ischemic heart disease: noninvasive imaging techniques and findings. Radiographics. 2021;41:990–1021.CrossRefPubMed Sirajuddin A, Mirmomen SM, Kligerman SJ, Groves DW, Burke AP, Kureshi F, et al. Ischemic heart disease: noninvasive imaging techniques and findings. Radiographics. 2021;41:990–1021.CrossRefPubMed
22.
go back to reference Bjarnason-Wehrens B. Elderly patients with ischaemic heart disease need our attention! Eur J Prev Cardiol. 2018;25:276–7.CrossRefPubMed Bjarnason-Wehrens B. Elderly patients with ischaemic heart disease need our attention! Eur J Prev Cardiol. 2018;25:276–7.CrossRefPubMed
23.
go back to reference Yang, Pen Z et al. Life’s Simple 7 and ischemic heart disease in the general Australian population. PLoS ONE. 2017;12. Yang, Pen Z et al. Life’s Simple 7 and ischemic heart disease in the general Australian population. PLoS ONE. 2017;12.
24.
go back to reference Xia W, Hongyan R, Enbo M, Gonghuan Y. Mortality trends for ischemic heart disease in China: an analysis of 102 continuous disease surveillance points from 1991 to 2009. BMC Public Health. 2017;18. Xia W, Hongyan R, Enbo M, Gonghuan Y. Mortality trends for ischemic heart disease in China: an analysis of 102 continuous disease surveillance points from 1991 to 2009. BMC Public Health. 2017;18.
25.
go back to reference Hongli Z, Bi X, Zheng N, Li C, Yan K. Joint effect of alcohol drinking and tobacco smoking on all-cause mortality and premature death in China: a cohort study. PLoS ONE. 2021;16:e0245670.CrossRefPubMedPubMedCentral Hongli Z, Bi X, Zheng N, Li C, Yan K. Joint effect of alcohol drinking and tobacco smoking on all-cause mortality and premature death in China: a cohort study. PLoS ONE. 2021;16:e0245670.CrossRefPubMedPubMedCentral
26.
go back to reference Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global burden of diseases, injuries, and risk factors study 2010 (GBD 2010) and the GBD stroke experts group. Global and regional burden of stroke during 1990–2010: findings from the global burden of Disease Study 2010. Lancet. 2014;383:245–54.CrossRefPubMedPubMedCentral Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global burden of diseases, injuries, and risk factors study 2010 (GBD 2010) and the GBD stroke experts group. Global and regional burden of stroke during 1990–2010: findings from the global burden of Disease Study 2010. Lancet. 2014;383:245–54.CrossRefPubMedPubMedCentral
27.
go back to reference Tong X, Yang Q, Ritchey MD, George MG, Jackson SL, Gillespie C et al. The burden of cerebrovascular disease in the United States. Prev Chronic Dis. 2019;16. Tong X, Yang Q, Ritchey MD, George MG, Jackson SL, Gillespie C et al. The burden of cerebrovascular disease in the United States. Prev Chronic Dis. 2019;16.
28.
29.
go back to reference O’Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388:761–75.CrossRefPubMed O’Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388:761–75.CrossRefPubMed
30.
go back to reference Ma Q, Li R, Wang L, Yin P, Wang Y, Yan C, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990–2019: an analysis for the global burden of Disease Study 2019. Lancet Public Health. 2021;6:e897–906.CrossRefPubMedPubMedCentral Ma Q, Li R, Wang L, Yin P, Wang Y, Yan C, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990–2019: an analysis for the global burden of Disease Study 2019. Lancet Public Health. 2021;6:e897–906.CrossRefPubMedPubMedCentral
31.
go back to reference Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice guidelines. Circulation. 2019;140:e596–646.PubMedPubMedCentral Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice guidelines. Circulation. 2019;140:e596–646.PubMedPubMedCentral
32.
go back to reference Cho IY, Lee KM, Lee Y et al. Assessment of Dietary Habits using the Diet Quality Index-International in Cerebrovascular and Cardiovascular Disease Patients[J]. Nutrients. 2021;13. Cho IY, Lee KM, Lee Y et al. Assessment of Dietary Habits using the Diet Quality Index-International in Cerebrovascular and Cardiovascular Disease Patients[J]. Nutrients. 2021;13.
33.
go back to reference Haibin Li B. Assessment of risk factors for cerebrovascular disease among the elderly in Beijing: a 23-year community-based prospective study in China. Arch Gerontol Geriatr. 2018;79:39–44.CrossRefPubMed Haibin Li B. Assessment of risk factors for cerebrovascular disease among the elderly in Beijing: a 23-year community-based prospective study in China. Arch Gerontol Geriatr. 2018;79:39–44.CrossRefPubMed
34.
go back to reference Lin X, Liao Y, Hao Y. The burden of cardio-cerebrovascular disease and lung cancer attributable to PM2.5 for 2009, Guangzhou: a retrospective population-based study. Int J Environ Health Res. 2018;29:1–11. Lin X, Liao Y, Hao Y. The burden of cardio-cerebrovascular disease and lung cancer attributable to PM2.5 for 2009, Guangzhou: a retrospective population-based study. Int J Environ Health Res. 2018;29:1–11.
35.
go back to reference Yueqi Z, Hongbo Z, Yiran Z, Huayin W, Liming W, Gen Z et al. Endovascular metal devices for the treatment of cerebrovascular diseases. Adv Mater (Deerfield Beach Fla). 2019;31. Yueqi Z, Hongbo Z, Yiran Z, Huayin W, Liming W, Gen Z et al. Endovascular metal devices for the treatment of cerebrovascular diseases. Adv Mater (Deerfield Beach Fla). 2019;31.
36.
go back to reference Ye P, Yuliang Er H, Wang et al. Burden of falls among people aged 60 years and older in mainland China, 1990–2019: findings from the Global Burden of Disease Study 2019. [J]. Lancet Public Health. 2021; 6;1:e907–18. Ye P, Yuliang Er H, Wang et al. Burden of falls among people aged 60 years and older in mainland China, 1990–2019: findings from the Global Burden of Disease Study 2019. [J]. Lancet Public Health. 2021; 6;1:e907–18.
37.
go back to reference Taekyoung K, Choi Sang D, Shuping X. Epidemiology of fall and its socioeconomic risk factors in community-dwelling korean elderly. PLoS ONE. 2020;15. Taekyoung K, Choi Sang D, Shuping X. Epidemiology of fall and its socioeconomic risk factors in community-dwelling korean elderly. PLoS ONE. 2020;15.
38.
go back to reference WHO. Step safely: strategies for preventing and managing falls across the life-course. Geneva: World Health Organization; 2021. WHO. Step safely: strategies for preventing and managing falls across the life-course. Geneva: World Health Organization; 2021.
39.
go back to reference Moreland B, Kakara R, Henry A. Trends in nonfatal falls and fall-related injuries among adults aged ≥ 65 years – United States. MMWR Morb Mortal Wkly Rep. 2012–2018;69:875 – 81. Moreland B, Kakara R, Henry A. Trends in nonfatal falls and fall-related injuries among adults aged ≥ 65 years – United States. MMWR Morb Mortal Wkly Rep. 2012–2018;69:875 – 81.
40.
go back to reference Li Fenfen, Zhou D, Chen Y, Yu Y, Gao N, Peng J et al. The association between health beliefs and fall-related behaviors and its implication for fall intervention among chinese elderly. Int J Environ Res Public Health. 2019;16. Li Fenfen, Zhou D, Chen Y, Yu Y, Gao N, Peng J et al. The association between health beliefs and fall-related behaviors and its implication for fall intervention among chinese elderly. Int J Environ Res Public Health. 2019;16.
41.
go back to reference Kza B, Jq C, Pza B et al. The mortality trends of falls among the elderly adults in the mainland of China. 2013–2020: a population-based study through the National Disease Surveillance points system[J]. The Lancet Regional Health - Western Pacific;19. Kza B, Jq C, Pza B et al. The mortality trends of falls among the elderly adults in the mainland of China. 2013–2020: a population-based study through the National Disease Surveillance points system[J]. The Lancet Regional Health - Western Pacific;19.
42.
go back to reference Fan J, Yu C, Guo Y, Bian Z, Sun Z, Yang L, et al. Frailty index and all-cause and cause-specific mortality in chinese adults: a prospective cohort study. Lancet Public Health. 2020;5:e650–60.CrossRefPubMedPubMedCentral Fan J, Yu C, Guo Y, Bian Z, Sun Z, Yang L, et al. Frailty index and all-cause and cause-specific mortality in chinese adults: a prospective cohort study. Lancet Public Health. 2020;5:e650–60.CrossRefPubMedPubMedCentral
43.
go back to reference Zhang Y, Zhou L, Liu S, Qiao Y, Wu Y, Ke C, et al. Prevalence, correlates and outcomes of multimorbidity among the middle-aged and elderly: findings from the China Health and Retirement Longitudinal Study. Arch Gerontol Geriatr. 2020;90:104135.CrossRefPubMed Zhang Y, Zhou L, Liu S, Qiao Y, Wu Y, Ke C, et al. Prevalence, correlates and outcomes of multimorbidity among the middle-aged and elderly: findings from the China Health and Retirement Longitudinal Study. Arch Gerontol Geriatr. 2020;90:104135.CrossRefPubMed
44.
go back to reference Angela S, José L, Jesús VB. Real-Life/real-time elderly fall detection with a triaxial accelerometer. Sensors. 2018;18:1101.CrossRef Angela S, José L, Jesús VB. Real-Life/real-time elderly fall detection with a triaxial accelerometer. Sensors. 2018;18:1101.CrossRef
Metadata
Title
Trends in all-cause mortality and leading causes of death from 2009 to 2019 among older adults in China
Authors
Jian Wu
Zihan Mu
Shuai Jiang
Yudong Miao
Yanyu Tang
Jing Wang
Suxian Wang
Yaojun Zhao
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2023
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-023-04346-7

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