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Child's Nervous System

04-04-2024 | Tremor | Research

Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience

Authors: Simone Peraio, Giorgio Mantovani, Tommaso Araceli, Lorenzo Mongardi, Alice Noris, Edoardo Fino, Francesca Formica, Luigi Piccinini, Federico Melani, Matteo Lenge, Roberta Scalise, Roberta Battini, Andrea Di Rita, Ludovico D’Incerti, Tayler Appleton, Michele Alessandro Cavallo, Renzo Guerrini, Flavio Giordano

Published in: Child's Nervous System

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Abstract

Purpose

Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.

Methods

We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.

Results

Mean follow-up was 48 months (range: 36–60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.

Conclusion

Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients.
Literature
1.
Issar NM, Hedera P, Phibbs FT, Konrad PE, Neimat JS (2013) Treating post-traumatic tremor with deep brain stimulation: report of five cases. Parkinsonism Relat Disord 19(12):1100–1105CrossRefPubMed
2.
Krauss JK, Jankovic J (2002) Head injury and posttraumatic movement disorders. Neurosurgery 50(5):927–939PubMed
3.
Umemura A, Samadani U, Jaggi JL, Hurtig HI, Baltuch GH (2004) Thalamic deep brain stimulation for posttraumatic action tremor. Clin Neurol Neurosurg 106(4):280–283CrossRefPubMed
4.
Cenzato M, Colistra D, Iacopino G, Raftopoulos C, Sure U, Tatagiba M et al (2021) Holmes tremor: a delayed complication after resection of brainstem cavernomas. J Neurosurg 135(3):693–703CrossRef
5.
Netravathi M, Pal PK, Indira Devi B (2012) A clinical profile of 103 patients with secondary movement disorders: correlation of etiology with phenomenology. Eur J Neurol 19(2):226–233CrossRefPubMed
6.
7.
Harmon RL, Long DF, Shirtz J (1991) Treatment of post-traumatic midbrain resting-kinetic tremor with combined levodopa/carbidopa and carbamazepine. Brain Inj 5(2):213–218CrossRefPubMed
8.
Jacob PC, Pratap Chand R (1998) Posttraumatic rubral tremor responsive to clonazepam. Mov Disord 13(6):977–978CrossRefPubMed
9.
10.
Aisen ML, Holzer M, Rosen M, Dietz M, McDowell F (1991) Glutethimide treatment of disabling action tremor in patients with multiple sclerosis and traumatic brain injury. Arch Neurol 48(5):513–515CrossRefPubMed
11.
Hallett M, Ravits J, Dubinsky RM, Gillespie MM, Moinfar A (1991) A double-blind trial of isoniazid for essential tremor and other action tremors. Mov Disord 6(3):253–256CrossRefPubMed
12.
Levy A, Chen R (2016) Myoclonus: pathophysiology and treatment options. Curr Treat Options Neurol 18(5):21CrossRefPubMed
13.
14.
Mittal SO, Lenka A, Jankovic J (2019) Botulinum toxin for the treatment of tremor. Parkinsonism Relat Disord 63:31–41CrossRefPubMed
15.
Louis ED, Barnes L, Wendt KJ, Ford B, Sangiorgio M, Tabbal S et al (2001) A teaching videotape for the assessment of essential tremor. Mov Disord 16(1):89–93CrossRefPubMed
16.
Bullard DE, Nashold BS (1984) Stereotaxic thalamotomy for treatment of posttraumatic movement disorders. J Neurosurg 61(2):316–321CrossRefPubMed
17.
18.
Rojas-Medina LM, Esteban-Fernández L, Rodríguez-Berrocal V, Álamo D, de Pedro M, Ley Urzaiz L, Bailly-Bailliere IR (2016) Deep brain stimulation in posttraumatic tremor: a series of cases and literature review. Stereotact Funct Neurosurg 94(6):379–386CrossRefPubMed
19.
Schuurman PR, Bosch DA, Merkus MP, Speelman JD (2008) Long-term follow-up of thalamic stimulation versus thalamotomy for tremor suppression. Mov Disord 23(8):1146–1153CrossRefPubMed
20.
Whiting BB, Whiting AC, Whiting DM (2018) Thalamic deep brain stimulation. Prog Neurol Surg 33:198–206CrossRefPubMed
21.
Blomstedt P, Fytagoridis A, Tisch S (2009) Deep brain stimulation of the posterior subthalamic area in the treatment of tremor. Acta Neurochir 151(1):31–36CrossRefPubMed
22.
Eisinger RS, Wong J, Almeida L, Ramirez-Zamora A, Cagle JN, Giugni JC et al (2018) Ventral intermediate nucleus versus zona incerta region deep brain stimulation in essential tremor. Mov Disord Clin Pract 5(1):75–82CrossRefPubMed
23.
Awad A, Blomstedt P, Westling G, Eriksson J (2020) Deep brain stimulation in the caudal zona incerta modulates the sensorimotor cerebello-cerebral circuit in essential tremor. Neuroimage 209:116511CrossRefPubMed
24.
Chen T, Mirzadeh Z, Chapple K, Lambert M, Dhall R, Ponce FA (2016) “Asleep” deep brain stimulation for essential tremor. J Neurosurg 124(6):1842–1849CrossRefPubMed
25.
Alesch F, Pinter MM, Helscher RJ, Fertl L, Benabid AL, Koos WTh (1995) Stimulation of the ventral intermediate thalamic nucleus in tremor dominated Parkinson’s disease and essential tremor. Acta neurochir 136(1–2):75–81CrossRefPubMed
26.
Andrew J, Fowler CJ, Harrison MJ (1982) Tremor after head injury and its treatment by stereotaxic surgery. J Neurol Neurosurg Psychiatry 45(9):815–819CrossRefPubMedPubMedCentral
27.
Carvalho KS, Sukul VV, Bookland MJ, Koch SA, Connolly PJ (2014) Deep brain stimulation of the globus pallidus suppresses post-traumatic dystonic tremor. J Clin Neurosci 21(1):153–155CrossRefPubMed
28.
Follett MA, Torres-Russotto D, Follett KA (2014) Bilateral deep brain stimulation of the ventral intermediate nucleus of the thalamus for posttraumatic midbrain tremor. Neuromodulation 17(3):289–291CrossRefPubMed
29.
Mongardi L, Rispoli V, Scerrati A, Giordano F, Capone JG, Vaudano AE, De Bonis P, Morgante F, Picillo M, Cavallo MA, Sensi M (2020) Deep brain stimulation of the ventralis oralis anterior thalamic nucleus is effective for dystonic tremor. Parkinsonism Relat Disord 81:8–11CrossRefPubMed
30.
31.
Krauss JK, Mohadjer M, Nobbe F, Mundinger F (1994) The treatment of posttraumatic tremor by stereotactic surgery: symptomatic and functional outcome in a series of 35 patients. J Neurosurg 80(5):810–819CrossRefPubMed
32.
Middlebrooks EH, Domingo RA, Vivas Buitrago T, Okromelidze L, Tsuboi T, Wong JK et al (2020) Neuroimaging advances in deep brain stimulation: review of indications, anatomy, and brain connectomics. R Am J Neuroradiol 41(9):1558–1568CrossRefPubMed
33.
Tsuboi T, Wong JK, Eisinger RS, Okromelidze L, Burns MR, Ramirez-Zamora A et al (2021) Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation. Brain 144(6):1774–1786CrossRefPubMed
34.
Foote KD, Okun MS (2005) Ventralis intermedius plus ventralis oralis anterior and posterior deep brain stimulation for posttraumatic holmes tremor: two leads may be better than one: technical note. Operative Neurosurgery 56(suppl_4):ONS-E445-ONS-E445CrossRef
35.
Mendonça MD, Meira B, Fernandes M, Barbosa R, Bugalho P (2018) Deep brain stimulation for lesion-related tremors: a systematic review and meta-analysis. Parkinsonism Relat Disord 47:8–14CrossRefPubMed
36.
Foote KD, Seignourel P, Fernandez HH, Romrell J, Whidden E, Jacobson C, Rodriguez RL, Okun MS (2006) Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor. Neurosurgery 58(4 Suppl 2):ONS-280-ONS−285
37.
Sitsapesan HA, Holland P, Oliphant Z, De Pennington N, Brittain JS, Jenkinson N et al (2014) Deep brain stimulation for tremor resulting from acquired brain injury. J Neurol Neurosurg Psychiatry 85(7):811–815CrossRefPubMed
38.
Franzini A, Cordella R, Messina G, Marras CE, Romito LM, Carella F et al (2011) Deep brain stimulation for movement disorders. Considerations on 276 consecutive patients. J Neural Transm 10:1497–1510CrossRef
39.
Canaz H, Karalok I, Topcular B, Agaoglu M, Yapici Z, Aydin S (2018) DBS in pediatric patients: institutional experience. Childs Nerv Syst 34(9):1771–1776CrossRefPubMed
Metadata
Title
Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience
Authors
Simone Peraio
Giorgio Mantovani
Tommaso Araceli
Lorenzo Mongardi
Alice Noris
Edoardo Fino
Francesca Formica
Luigi Piccinini
Federico Melani
Matteo Lenge
Roberta Scalise
Roberta Battini
Andrea Di Rita
Ludovico D’Incerti
Tayler Appleton
Michele Alessandro Cavallo
Renzo Guerrini
Flavio Giordano
Publication date
04-04-2024
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-024-06380-1