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Open Access 01-04-2014 | Review

Treatment with echinocandins during continuous renal replacement therapy

Authors: Francisco Javier González de Molina, MariadeLosÁngeles Martínez-Alberici, Ricard Ferrer

Published in: Critical Care | Issue 2/2014

Abstract

Echinocandins are indicated as first-line treatment for invasive candidiasis in moderate to severe illness. As sepsis is the main cause of acute kidney injury, the combination of echinocandin treatment and continuous renal replacement therapy (CRRT) is common. Optimizing antibiotic dosage in critically ill patients receiving CRRT is challenging. The pharmacokinetics of echinocandins have been studied under various clinical conditions; however, data for CRRT patients are scarce. Classically, drugs like echinocandins with high protein binding and predominantly non-renal elimination are not removed by CRRT, indicating that no dosage adjustment is required. However, recent studies report different proportions of echinocandins lost by filter adsorption. Nevertheless, the clinical significance of these findings remains unclear.

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Title: Treatment with echinocandins during continuous renal replacement therapy
Authors: Francisco Javier González de Molina
MariadeLosÁngeles Martínez-Alberici
Ricard Ferrer
Publication date: 01-04-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc13803

At a glance: The STEP trials

Springer Medicine

Treatment with echinocandins during continuous renal replacement therapy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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