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Clinical Oral Investigations
Published in: Clinical Oral Investigations 8/2019

01-08-2019 | Original Article

Treatment outcomes and prognostic factors of medication-related osteonecrosis of the jaw: a case- and literature-based review

Authors: Shin-ichi Yamada, Hiroshi Kurita, Eiji Kondo, Shigeru Suzuki, Fumihiro Nishimaki, Nobuhiko Yoshimura, Masafumi Morioka, Shutaro Ishii, Takahiro Kamata

Published in: Clinical Oral Investigations | Issue 8/2019

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Abstract

Objectives

The purpose of this study was to investigate the treatment outcomes and prognostic factors of medication-related osteonecrosis of the jaw (MRONJ) in Japanese patients.

Patients and methods

Among 409 cases, treatment outcomes and prognostic factors were investigated in 275 patients. In statistical analyses, the 1-year cumulative curative rate was calculated with the Kaplan-Meier method, and significance was examined with the Wilcoxon test. Cox’s proportional hazards regression analysis was used for the multivariate analysis.

Results

Resolution of the disease was achieved in 137 out of 275 MRONJ patients (49.8%). One-year cumulative curative rates were 39.8% in stage 1 patients, 26.3% in stage 2, and 19.0% in stage 3. The 1-year cumulative curative rates of treatment interventions were 17.2% for conservative treatment, 34.5% for sequestrectomy, and 40.7% for extended surgery including bone resection and segmental resection. As the prognostic factors of treatment outcomes, the type of medication, stage of MRONJ, and type of surgical intervention were identified as independent factors in a multivariate analysis.

Conclusion

These results suggest that surgical interventions may lead to a good prognosis in MRONJ patients.

Clinical relevance

This study indicated that surgical intervention for MRONJ might lead to improvement of prognosis and quality of life in MRONJ patients.
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Metadata
Title
Treatment outcomes and prognostic factors of medication-related osteonecrosis of the jaw: a case- and literature-based review
Authors
Shin-ichi Yamada
Hiroshi Kurita
Eiji Kondo
Shigeru Suzuki
Fumihiro Nishimaki
Nobuhiko Yoshimura
Masafumi Morioka
Shutaro Ishii
Takahiro Kamata
Publication date
01-08-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 8/2019
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2743-0

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