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01-12-2016 | Original Article

Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine

Authors: Yifei Ma, Jialin Li, Jun Pan, Wangjun Yan, Quan Huang, Tielong Liu, Xinghai Yang, Cheng Yang, Wei Xu, Haifeng Wei, Jianru Xiao

Published in: European Spine Journal | Issue 12/2016

Abstract

Background

Giant cell tumor of the spine has high rate of postoperative recurrence. There are not much published studies on repeatedly recurrent GCTS (RRGCTS). Also, there are controversies as to the prognostic factors and treatment options for RRGCTS.

Methods and materials

A retrospective survival analysis between 2000 and September 2014 was performed on the 74 times of in-hospital treatment of the 21 patients. Recurrence-free survival was defined as the time between the date of surgery and the date of recurrence. Factors with P values <0.05 in univariate analysis were subjected to multivariate analysis by means of proportional hazard analysis.

Result

A total of 21 patients comprising ten males and 11 females with a mean age of 29.7 years (range 15–49) were included, with a total of 74 times of surgery performed. Eighteen patients had no evidence of disease. Univariate and multivariate analysis suggested that total spondylectomy and bisphosphonate therapy were independent prognostic factors for better RFS in RRGCTS patients.

Conclusion

Patients of RRGCTS are suitable for further surgical treatment with relatively good healing process and restoration of nervous function. Early diagnosis of recurrence may be associated with better prognosis. Total spondylectomy in combination with bisphosphonate therapy could reduce postoperative recurrence rate.

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Title: Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine
Authors: Yifei Ma
Jialin Li
Jun Pan
Wangjun Yan
Quan Huang
Tielong Liu
Xinghai Yang
Cheng Yang
Wei Xu
Haifeng Wei
Jianru Xiao
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 12/2016
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-015-4348-5

At a glance: The STEP trials

Springer Medicine

Treatment options and prognosis for repeatedly recurrent giant cell tumor of the spine

Abstract

Background

Methods and materials

Result

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods and materials

Result

Conclusion

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