Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Psychiatry
Published in: BMC Psychiatry 1/2014

Open Access 01-12-2014 | Study protocol

Treatment of bipolar disorder in the Netherlands and concordance with treatment guidelines: study protocol of an observational, longitudinal study on naturalistic treatment of bipolar disorder in everyday clinical practice

Authors: Joannes W Renes, Eline J Regeer, Trijntje YG van der Voort, Willem A Nolen, Ralph W Kupka

Published in: BMC Psychiatry | Issue 1/2014

Login to get access

Abstract

Background

While various guidelines on the treatment of bipolar disorder have been published over the last decades, adherence to guidelines has been reported to be low. In this article we describe the protocol of a nationwide, multicenter, longitudinal, non-intervention study on the treatment of bipolar disorder in the Netherlands. Study aims are to provide information on the nature and content of outpatient treatment of bipolar disorder, to determine to what extent treatment is in concordance with the Dutch guideline for the treatment of bipolar disorder (2008), and to investigate the relationship of guideline concordance with symptomatic and functional outcome.

Methods/Design

Between December 2009 and February 2010, all psychiatrists registered as member of the Dutch Psychiatric Association received a questionnaire with questions about their treatment setting, and whether they would be willing to participate in further research. Psychiatrists treating adult outpatients with bipolar disorder were invited to participate. Consenting psychiatrist subsequently approached all their patients with bipolar disorder. The study is performed with written patient and caregiver surveys at baseline and after 12 months, including data on demographics, illness characteristics, organization of care, treatments received, symptomatic and functional outcome, quality of life, and burden of care for informal caregivers.

Discussion

This study will provide information on the naturalistic treatment of bipolar disorder in the Netherlands, as well as degree of concordance of this treatment with the Dutch guideline, and its relationship with symptomatic and functional outcome. Limitations of a survey-based study are discussed.
Literature
1.
Pini S, de Queiroz V, Pagnin D, Pezawas L, Angst J, Cassano GB, Wittchen HU: Prevalence and burden of bipolar disorders in European countries. Eur Neuropsychopharmacol. 2005, 15: 425-434. 10.1016/j.euroneuro.2005.04.011.CrossRefPubMed
2.
IsHak WW, Brown K, Aye SS, Kahloon M, Mobaraki S, Hanna R: Health-related quality of life in bipolar disorder. Bipolar Disord. 2012, 14: 6-18. 10.1111/j.1399-5618.2011.00969.x.CrossRefPubMed
3.
MacQueen GM, Young LT, Joffe RT: A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand. 2001, 103: 163-170. 10.1034/j.1600-0447.2001.00059.x.CrossRefPubMed
4.
Goossens PJ, Van Wijngaarden B, Knoppert-van Der Klein EA, Van Achterberg T: Family caregiving in bipolar disorder: caregiver consequences, caregiver coping styles, and caregiver distress. Int J Soc Psychiatry. 2008, 54: 303-316. 10.1177/0020764008090284.CrossRefPubMed
5.
Bauer MS: The collaborative practice model for bipolar disorder: design and implementation in a multi-site randomized controlled trial. Bipolar Disord. 2001, 3: 233-244. 10.1034/j.1399-5618.2001.30502.x.CrossRefPubMed
6.
Bauer MS, McBride L, Williford WO, Glick H, Kinosian B, Altshuler L, Beresford T, Kilbourne AM, Sajatovic M, Cooperative Studies Program 430 Study T: Collaborative care for bipolar disorder: part I. Intervention and implementation in a randomized effectiveness trial. Psychiatr Serv. 2006, 57: 927-936. 10.1176/appi.ps.57.7.927.CrossRefPubMed
7.
Simon GE, Ludman EJ, Unutzer J, Bauer MS, Operskalski B, Rutter C: Randomized trial of a population-based care program for people with bipolar disorder. Psychol Med. 2005, 35: 13-24. 10.1017/S0033291704002624.CrossRefPubMed
8.
Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B: Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry. 2006, 63: 500-508. 10.1001/archpsyc.63.5.500.CrossRefPubMed
9.
Kessing LV, Hansen HV, Hvenegaard A, Christensen EM, Dam H, Gluud C, Wetterslev J, Early Intervention Affective Disorders Trial G: Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial. Br J Psychiatry. 2013, 202: 212-219. 10.1192/bjp.bp.112.113548.CrossRefPubMed
10.
Suppes T, Rush AJ, Dennehy EB, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, Brown ES, Biggs MM, Shores-Wilson K, Witte BP, Trivedi MH, Miller AL, Altshuler KZ, Shon SP: Texas Medication Algorithm Project, phase 3 (TMAP-3): clinical results for patients with a history of mania. J Clin Psychiatry. 2003, 64: 370-382. 10.4088/JCP.v64n0403.CrossRefPubMed
11.
Bauer MS: A review of quantitative studies of adherence to mental health clinical practice guidelines. Harv Rev Psychiatry. 2002, 10: 138-153. 10.1080/10673220216217.CrossRefPubMed
12.
Baldessarini RJ, Leahy L, Arcona S, Gause D, Zhang W, Hennen J: Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 2007, 58: 85-91. 10.1176/appi.ps.58.1.85.CrossRefPubMed
13.
Lim PZ, Tunis SL, Edell WS, Jensik SE, Tohen M: Medication prescribing patterns for patients with bipolar I disorder in hospital settings: adherence to published practice guidelines. Bipolar Disord. 2001, 3: 165-173. 10.1034/j.1399-5618.2001.30401.x.CrossRefPubMed
14.
Blanco C, Laje G, Olfson M, Marcus SC, Pincus HA: Trends in the treatment of bipolar disorder by outpatient psychiatrists. Am J Psychiatry. 2002, 159: 1005-1010. 10.1176/appi.ajp.159.6.1005.CrossRefPubMed
15.
Ghaemi SN, Hsu DJ, Thase ME, Wisniewski SR, Nierenberg AA, Miyahara S, Sachs G: Pharmacological treatment patterns at study entry for the first 500 STEP-BD participants. Psychiatr Serv. 2006, 57: 660-665. 10.1176/appi.ps.57.5.660.CrossRefPubMed
16.
Nolen WA, Kupka RW PFJS, der Klein EAM K-v, Honig A, Reichart CG, Goossens PJJ, Daemen P, Ravelli DP: Richtlijn Bipolaire stoornissen. Nederlandse Vereniging voor Psychiatrie. 2008, Utrecht: De Tijdstroom
17.
Spearing MK, Post RM, Leverich GS, Brandt D, Nolen W: Modification of the Clinical Global Impressions (CGI) scale for use in bipolar illness (BP): the CGI-BP. Psychiatry Res. 1997, 73: 159-171. 10.1016/S0165-1781(97)00123-6.CrossRefPubMed
18.
Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, Crismon ML, Shores-Wilson K, Toprac MG, Dennehy EB, Witte B, Kashner TM: The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psychometric evaluation. Psychol Med. 2004, 34: 73-82. 10.1017/S0033291703001107.CrossRefPubMed
19.
Altman EG, Hedeker D, Peterson JL, Davis JM: The Altman Self-rating Mania Scale. Biol Psychiatry. 1997, 42: 948-955. 10.1016/S0006-3223(96)00548-3.CrossRefPubMed
20.
Trompenaars FJ, Masthoff ED, Van Heck GL, Hodiamont PP, De Vries J: Content validity, construct validity, and reliability of the WHOQOL-Bref in a population of Dutch adult psychiatric outpatients. Qual Life Res. 2005, 14: 151-160. 10.1007/s11136-004-0787-x.CrossRefPubMed
21.
Rosa AR, Sanchez-Moreno J, Martinez-Aran A, Salamero M, Torrent C, Reinares M, Comes M, Colom F, Van Riel W, Ayuso-Mateos JL, Kapczinski F, Vieta E: Validity and reliability of the Functioning Assessment Short Test (FAST) in bipolar disorder. Clin Pract Epidemiol Ment Health. 2007, 3: 5-10.1186/1745-0179-3-5.CrossRefPubMedPubMedCentral
22.
Hogan TP, Awad AG, Eastwood R: A self-report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity. Psychol Med. 1983, 13: 177-183. 10.1017/S0033291700050182.CrossRefPubMed
23.
van Wijngaarden B, Schene AH, Koeter M, Vazquez-Barquero JL, Knudsen HC, Lasalvia A, McCrone P: Caregiving in schizophrenia: development, internal consistency and reliability of the involvement evaluation questionnaire--european version. EPSILON study 4. European psychiatric services: inputs linked to outcome domains and needs. Br J Psychiatry Suppl. 2000, 39: s21-s27.CrossRefPubMed
24.
Hofman A, Honig A, Vossen M: Het manisch depressief syndroom; psycho-educatie als onderdeel van behandeling. Tijdschr Psychiatr. 1992, 34: 549-559.
25.
Vieta E, Blasco-Colmenares E, Figueira ML, Langosch JM, Moreno-Manzanaro M, Medina E, Group WA-bS: Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd study). BMC Psychiatry. 2011, 11: 58-10.1186/1471-244X-11-58.CrossRefPubMedPubMedCentral
26.
Leverich GS, Nolen WA, Rush AJ, McElroy SL, Keck PE, Denicoff KD, Suppes T, Altshuler LL, Kupka R, Kramlinger KG, Post RM: The Stanley Foundation Bipolar Treatment Outcome Network. I. Longitudinal methodology. J Affect Disord. 2001, 67: 33-44. 10.1016/S0165-0327(01)00430-X.CrossRefPubMed
27.
Suppes T, Leverich GS, Keck PE, Nolen WA, Denicoff KD, Altshuler LL, McElroy SL, Rush AJ, Kupka R, Frye MA, Bickel M, Post RM: The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001, 67: 45-59. 10.1016/S0165-0327(01)00432-3.CrossRefPubMed
Metadata
Title
Treatment of bipolar disorder in the Netherlands and concordance with treatment guidelines: study protocol of an observational, longitudinal study on naturalistic treatment of bipolar disorder in everyday clinical practice
Authors
Joannes W Renes
Eline J Regeer
Trijntje YG van der Voort
Willem A Nolen
Ralph W Kupka
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-14-58

Other articles of this Issue 1/2014

BMC Psychiatry 1/2014 Go to the issue

Study protocol

The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design

Technical advance

Manual for transference work scale; a micro-analytical tool for therapy process analyses

Research article

Results of a pilot randomised controlled trial to measure the clinical and cost effectiveness of peer support in increasing hope and quality of life in mental health patients discharged from hospital in the UK

Research article

The effectiveness of an anti-stigma intervention in a basic police officer training programme: a controlled study

Research article

Suicide in young adults: psychiatric and socio-economic factors from a case–control study

Research article

Association of serum leptin and ghrelin with depressive symptoms in a Japanese working population: a cross-sectional study