Skip to main content
Top
Published in: Radiation Oncology 1/2014

Open Access 01-12-2014 | Review

Treatment improvement and better patient care: which is the most important one in oral cavity cancer?

Authors: Francesca De Felice, Daniela Musio, Valentina Terenzi, Valentino Valentini, Andrea Cassoni, Mario Tombolini, Marco De Vincentiis, Vincenzo Tombolini

Published in: Radiation Oncology | Issue 1/2014

Login to get access

Abstract

Due to substantial improvement in diagnosis and treatment of oral cavity cancer, a better understanding of the patient care needs to be revised. We reviewed literature related to OCC and discussed current general management approaches and related long-term radiation toxicities to emphasize the multidisciplinary team involvement. New technical modalities and patient quality of life parameters should be an integral and paramount state in the clinical evaluation to significantly contribute to reduce secondary side effects.
Literature
1.
go back to reference Siegel R, Ma J, Zou Z, Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 2014, 64: 9-29. 10.3322/caac.21208.CrossRefPubMed Siegel R, Ma J, Zou Z, Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 2014, 64: 9-29. 10.3322/caac.21208.CrossRefPubMed
2.
go back to reference Périé S, Meyers M, Mazzaschi O, De Crouy CO, Baujat B, Lacau St Guily J: Epidemiology and anatomy of head and neck cancers. Bull Cancer. 2014, 101 (5): 404-410.PubMed Périé S, Meyers M, Mazzaschi O, De Crouy CO, Baujat B, Lacau St Guily J: Epidemiology and anatomy of head and neck cancers. Bull Cancer. 2014, 101 (5): 404-410.PubMed
3.
go back to reference Guan P, Howell-Jones R, Li N, Bruni L, de Sanjosé S, Franceschi S, Clifford GM: Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012, 131 (10): 2349-2359. 10.1002/ijc.27485.CrossRefPubMed Guan P, Howell-Jones R, Li N, Bruni L, de Sanjosé S, Franceschi S, Clifford GM: Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012, 131 (10): 2349-2359. 10.1002/ijc.27485.CrossRefPubMed
4.
go back to reference Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M: Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012, 6 (Suppl 1): S104-S120. 10.1007/s12105-012-0368-1.CrossRefPubMed Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M: Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review. Head Neck Pathol. 2012, 6 (Suppl 1): S104-S120. 10.1007/s12105-012-0368-1.CrossRefPubMed
5.
go back to reference Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, Lee A, Le QT, Maingon P, Nutting C, O'Sullivan B, Porceddu SV, Lengele B: Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol. 2014, 110 (1): 172-181. 10.1016/j.radonc.2013.10.010.CrossRefPubMed Grégoire V, Ang K, Budach W, Grau C, Hamoir M, Langendijk JA, Lee A, Le QT, Maingon P, Nutting C, O'Sullivan B, Porceddu SV, Lengele B: Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol. 2014, 110 (1): 172-181. 10.1016/j.radonc.2013.10.010.CrossRefPubMed
6.
go back to reference Halperin EC, Brady LW, Perez CA, Wazer DE: Principles and Practice of Radiation Oncology. 2013, Lippincott Williams and Wilkins, Philadelphia, 6 Halperin EC, Brady LW, Perez CA, Wazer DE: Principles and Practice of Radiation Oncology. 2013, Lippincott Williams and Wilkins, Philadelphia, 6
7.
go back to reference Edge S, Byrd D, Compton C: AJCC Cancer Staging Manual. 2009, Springer, New York, NY, USA, 7 Edge S, Byrd D, Compton C: AJCC Cancer Staging Manual. 2009, Springer, New York, NY, USA, 7
8.
go back to reference Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G: Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997, 80 (3): 351-356. 10.1002/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V.CrossRefPubMed Hiratsuka H, Miyakawa A, Nakamori K, Kido Y, Sunakawa H, Kohama G: Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity. Cancer. 1997, 80 (3): 351-356. 10.1002/(SICI)1097-0142(19970801)80:3<351::AID-CNCR1>3.0.CO;2-V.CrossRefPubMed
9.
go back to reference Dwivedi RC, Dwivedi RC, Kazi R, Kanwar N, Nutting CM, Harrington KJ, Rhys-Evans PH: Should the treatment paradigms for oral and oropharyngeal cancers be changed now: the role of human papilloma virus?. ANZ J Surg. 2011, 81 (9): 581-583. 10.1111/j.1445-2197.2011.05829.x.CrossRefPubMed Dwivedi RC, Dwivedi RC, Kazi R, Kanwar N, Nutting CM, Harrington KJ, Rhys-Evans PH: Should the treatment paradigms for oral and oropharyngeal cancers be changed now: the role of human papilloma virus?. ANZ J Surg. 2011, 81 (9): 581-583. 10.1111/j.1445-2197.2011.05829.x.CrossRefPubMed
10.
go back to reference Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL: Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005, 27 (10): 843-850. 10.1002/hed.20279.CrossRefPubMed Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, Ozsahin EM, Jacobs JR, Jassem J, Ang KK, Lefèbvre JL: Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005, 27 (10): 843-850. 10.1002/hed.20279.CrossRefPubMed
12.
go back to reference Cousins N, MacAulay F, Lang H, MacGillivray S, Wells M: A systematic review of interventions for eating and drinking problems following treatment for head and neck cancer suggests a need to look beyond swallowing and trismus. Oral Oncol. 2013, 49 (5): 387-400. 10.1016/j.oraloncology.2012.12.002.CrossRefPubMed Cousins N, MacAulay F, Lang H, MacGillivray S, Wells M: A systematic review of interventions for eating and drinking problems following treatment for head and neck cancer suggests a need to look beyond swallowing and trismus. Oral Oncol. 2013, 49 (5): 387-400. 10.1016/j.oraloncology.2012.12.002.CrossRefPubMed
13.
go back to reference van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Hilgers FJ: Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol. 2009, 266 (6): 889-900. 10.1007/s00405-008-0817-3.CrossRefPubMed van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Hilgers FJ: Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol. 2009, 266 (6): 889-900. 10.1007/s00405-008-0817-3.CrossRefPubMed
14.
go back to reference Gritz ER, Carr CR, Rapkin D, Abemayor E, Chang LJ, Wong WK, Belin TR, Calcaterra T, Robbins KT, Chonkich G: Predictors of long-term smoking cessation in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 1993, 2 (3): 261-270.PubMed Gritz ER, Carr CR, Rapkin D, Abemayor E, Chang LJ, Wong WK, Belin TR, Calcaterra T, Robbins KT, Chonkich G: Predictors of long-term smoking cessation in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 1993, 2 (3): 261-270.PubMed
15.
go back to reference Slaughter DP, Southwich HW, Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953, 6 (5): 963-968. 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q.CrossRefPubMed Slaughter DP, Southwich HW, Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953, 6 (5): 963-968. 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q.CrossRefPubMed
16.
go back to reference Day GL, Blot WJ: Second primary tumors in patients with oral cancer. Cancer. 1992, 70 (1): 14-19. 10.1002/1097-0142(19920701)70:1<14::AID-CNCR2820700103>3.0.CO;2-S.CrossRefPubMed Day GL, Blot WJ: Second primary tumors in patients with oral cancer. Cancer. 1992, 70 (1): 14-19. 10.1002/1097-0142(19920701)70:1<14::AID-CNCR2820700103>3.0.CO;2-S.CrossRefPubMed
17.
go back to reference Languis JA, van Dijk AM, Doornaert P, Kruizenga HM, Langendijk JA, Leemans CR, Weijs PJ, Verdonck-de Leeuw IM: More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with deterioration in quality of life. Nutr Cancer. 2013, 65 (1): 76-83. 10.1080/01635581.2013.741749.CrossRef Languis JA, van Dijk AM, Doornaert P, Kruizenga HM, Langendijk JA, Leemans CR, Weijs PJ, Verdonck-de Leeuw IM: More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with deterioration in quality of life. Nutr Cancer. 2013, 65 (1): 76-83. 10.1080/01635581.2013.741749.CrossRef
18.
go back to reference Nguyen NP, North D, Smith HJ, Dutta S, Alfieri A, Karlsson U, Lee H, Martinez T, Lemanski C, Nguyen LM, Ludin A, Sallah S: Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surg Oncol. 2006, 15 (4): 199-203. 10.1016/j.suronc.2006.12.002.CrossRefPubMed Nguyen NP, North D, Smith HJ, Dutta S, Alfieri A, Karlsson U, Lee H, Martinez T, Lemanski C, Nguyen LM, Ludin A, Sallah S: Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surg Oncol. 2006, 15 (4): 199-203. 10.1016/j.suronc.2006.12.002.CrossRefPubMed
19.
go back to reference Ghezzi EM, Lange LA, Ship JA: Determination of variation of stimulated salivary flow rates. J Dent Res. 2000, 79 (11): 1874-1878. 10.1177/00220345000790111001.CrossRefPubMed Ghezzi EM, Lange LA, Ship JA: Determination of variation of stimulated salivary flow rates. J Dent Res. 2000, 79 (11): 1874-1878. 10.1177/00220345000790111001.CrossRefPubMed
20.
go back to reference Kontis T, Johns M: Anatomy and Physiology of the Salivary Glands. Head and Neck Surgery – Otolaryngology. Edited by: Bailey BJ. 2001, Lippincott Williams and Wilkins, Philadelphia, 2 Kontis T, Johns M: Anatomy and Physiology of the Salivary Glands. Head and Neck Surgery – Otolaryngology. Edited by: Bailey BJ. 2001, Lippincott Williams and Wilkins, Philadelphia, 2
21.
go back to reference Trotti A, Eisbruch A: Reducing xerostomia through advanced technology. Lancet Oncol. 2011, 12 (2): 110-111. 10.1016/S1470-2045(11)70009-2.CrossRefPubMed Trotti A, Eisbruch A: Reducing xerostomia through advanced technology. Lancet Oncol. 2011, 12 (2): 110-111. 10.1016/S1470-2045(11)70009-2.CrossRefPubMed
22.
go back to reference Vissink A, Jansma J, Spijkervet FK, Burlage FR, Coppes RP: Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003, 14 (3): 199-212. 10.1177/154411130301400305.CrossRefPubMed Vissink A, Jansma J, Spijkervet FK, Burlage FR, Coppes RP: Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003, 14 (3): 199-212. 10.1177/154411130301400305.CrossRefPubMed
23.
go back to reference Bergonie J: Sur quelques formes de reactions precoces apres des irradiations. Arch Elect Med. 1911, 19: 241-245. Bergonie J: Sur quelques formes de reactions precoces apres des irradiations. Arch Elect Med. 1911, 19: 241-245.
24.
go back to reference Konings AW, Faber H, Cotteleer F, Vissink A, Coppes RP: Secondary radiation damage as the main cause for unexpected volume effects: a histopathologic study of parotid gland. Int J Radiat Oncol Biol Phys. 2006, 64 (1): 98-105. 10.1016/j.ijrobp.2005.06.042.CrossRefPubMed Konings AW, Faber H, Cotteleer F, Vissink A, Coppes RP: Secondary radiation damage as the main cause for unexpected volume effects: a histopathologic study of parotid gland. Int J Radiat Oncol Biol Phys. 2006, 64 (1): 98-105. 10.1016/j.ijrobp.2005.06.042.CrossRefPubMed
25.
go back to reference Coppes RP, Roffel AF, Zeilstra LJ, Vissink A, Konings AW: Early radiation effects on muscarinic receptor-induced secretory responsiveness of the parotid gland in the freely moving rat. Radiat Res. 2000, 153 (3): 339-346. 10.1667/0033-7587(2000)153[0339:EREOMR]2.0.CO;2.CrossRefPubMed Coppes RP, Roffel AF, Zeilstra LJ, Vissink A, Konings AW: Early radiation effects on muscarinic receptor-induced secretory responsiveness of the parotid gland in the freely moving rat. Radiat Res. 2000, 153 (3): 339-346. 10.1667/0033-7587(2000)153[0339:EREOMR]2.0.CO;2.CrossRefPubMed
26.
go back to reference Nagler RM: The enigmatic mechanism of irradiation-induced damage to the major salivary glands. Oral Dis. 2002, 8 (3): 141-146. 10.1034/j.1601-0825.2002.02838.x.CrossRefPubMed Nagler RM: The enigmatic mechanism of irradiation-induced damage to the major salivary glands. Oral Dis. 2002, 8 (3): 141-146. 10.1034/j.1601-0825.2002.02838.x.CrossRefPubMed
27.
go back to reference Abok K, Brunk U, Jung B, Ericsson J: Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984, 45 (4): 443-460. 10.1007/BF02889885.CrossRefPubMed Abok K, Brunk U, Jung B, Ericsson J: Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984, 45 (4): 443-460. 10.1007/BF02889885.CrossRefPubMed
28.
go back to reference Konings AW, Coppes RP, Vissink A: On the mechanism of salivary gland radiosensitivity. Int J Radiat Oncol Biol Phys. 2005, 62 (4): 1187-1194. 10.1016/j.ijrobp.2004.12.051.CrossRefPubMed Konings AW, Coppes RP, Vissink A: On the mechanism of salivary gland radiosensitivity. Int J Radiat Oncol Biol Phys. 2005, 62 (4): 1187-1194. 10.1016/j.ijrobp.2004.12.051.CrossRefPubMed
29.
go back to reference Messmer MB, Thomsen A, Kirste S, Becker G, Momm F: Xerostomia after radiotherapy in the head & neck area: long-term observations. Radiother Oncol. 2011, 98 (1): 48-50. 10.1016/j.radonc.2010.10.013.CrossRefPubMed Messmer MB, Thomsen A, Kirste S, Becker G, Momm F: Xerostomia after radiotherapy in the head & neck area: long-term observations. Radiother Oncol. 2011, 98 (1): 48-50. 10.1016/j.radonc.2010.10.013.CrossRefPubMed
30.
go back to reference Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, Miles EA, Miah AB, Newbold K, Tanay M, Adab F, Jefferies SJ, Scrase C, Yap BK, A'Hern RP, Sydenham MA, Emson M, Hall E, PARSPORT trial management group: Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011, 12 (2): 127-136. 10.1016/S1470-2045(10)70290-4.PubMedCentralCrossRefPubMed Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, Miles EA, Miah AB, Newbold K, Tanay M, Adab F, Jefferies SJ, Scrase C, Yap BK, A'Hern RP, Sydenham MA, Emson M, Hall E, PARSPORT trial management group: Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2011, 12 (2): 127-136. 10.1016/S1470-2045(10)70290-4.PubMedCentralCrossRefPubMed
31.
go back to reference Brizel DM, Wasserman TH, Henke M, Strnad V, Rudat V, Monnier A, Eschwege F, Zhang J, Russell L, Oster W, Sauer R: Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol. 2000, 18 (19): 3339-3345.PubMed Brizel DM, Wasserman TH, Henke M, Strnad V, Rudat V, Monnier A, Eschwege F, Zhang J, Russell L, Oster W, Sauer R: Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol. 2000, 18 (19): 3339-3345.PubMed
32.
go back to reference Burlage FR, Roesink JM, Kampinga HH, Coppes RP, Terhaard C, Langendijk JA, van Luijk P, Stokman MA, Vissink A: Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study. Int J Radiat Oncol Biol Phys. 2008, 70 (1): 14-22. 10.1016/j.ijrobp.2007.06.016.CrossRefPubMed Burlage FR, Roesink JM, Kampinga HH, Coppes RP, Terhaard C, Langendijk JA, van Luijk P, Stokman MA, Vissink A: Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study. Int J Radiat Oncol Biol Phys. 2008, 70 (1): 14-22. 10.1016/j.ijrobp.2007.06.016.CrossRefPubMed
33.
go back to reference Pringle S, Van Os R, Coppes RP: Concise review: adult salivary gland stem cells and a potential therapy for xerostomia. Stem Cells. 2013, 31 (4): 613-619. 10.1002/stem.1327.CrossRefPubMed Pringle S, Van Os R, Coppes RP: Concise review: adult salivary gland stem cells and a potential therapy for xerostomia. Stem Cells. 2013, 31 (4): 613-619. 10.1002/stem.1327.CrossRefPubMed
34.
go back to reference Beekhuis GJ, Harrington EB: Trismus. Etiology and management of inability to open the mouth. Laryngoscope. 1965, 75: 1234-1258. 10.1288/00005537-196508000-00003.CrossRefPubMed Beekhuis GJ, Harrington EB: Trismus. Etiology and management of inability to open the mouth. Laryngoscope. 1965, 75: 1234-1258. 10.1288/00005537-196508000-00003.CrossRefPubMed
35.
go back to reference Dhanrajani PJ, Jonaidel O: Trismus: aetiology, differential diagnosis and treatment. Dent Update. 2002, 29 (2): 88-92. 94PubMed Dhanrajani PJ, Jonaidel O: Trismus: aetiology, differential diagnosis and treatment. Dent Update. 2002, 29 (2): 88-92. 94PubMed
36.
go back to reference Delanian S, Lefaix JL: The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004, 73 (2): 119-131. 10.1016/j.radonc.2004.08.021.CrossRefPubMed Delanian S, Lefaix JL: The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004, 73 (2): 119-131. 10.1016/j.radonc.2004.08.021.CrossRefPubMed
37.
go back to reference Wang CJ, Huang EY, Hsu HC, Chen HC, Fang FM, Hsiung CY: The degree and time-course assessment of radiation-induced trismus occurring after radiotherapy for nasopharyngeal cancer. Laryngoscope. 2005, 115 (8): 1458-1460. 10.1097/01.mlg.0000171019.80351.46.CrossRefPubMed Wang CJ, Huang EY, Hsu HC, Chen HC, Fang FM, Hsiung CY: The degree and time-course assessment of radiation-induced trismus occurring after radiotherapy for nasopharyngeal cancer. Laryngoscope. 2005, 115 (8): 1458-1460. 10.1097/01.mlg.0000171019.80351.46.CrossRefPubMed
38.
go back to reference Hsieh LC, Chen JW, Wang LY, Tsang YM, Shueng PW, Liao LJ, Lo WC, Lin YC, Tseng CF, Kuo YS, Jhuang JY, Tien HJ, Juan HF, Hsieh CH: Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. PLoS One. 2014, 9 (3): e92561-10.1371/journal.pone.0092561.PubMedCentralCrossRefPubMed Hsieh LC, Chen JW, Wang LY, Tsang YM, Shueng PW, Liao LJ, Lo WC, Lin YC, Tseng CF, Kuo YS, Jhuang JY, Tien HJ, Juan HF, Hsieh CH: Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. PLoS One. 2014, 9 (3): e92561-10.1371/journal.pone.0092561.PubMedCentralCrossRefPubMed
39.
go back to reference Dijkstra PU, Kalk WW, Roodenburg JL: Trismus in head and neck oncology: a systematic review. Oral Oncol. 2004, 40 (9): 879-889. 10.1016/j.oraloncology.2004.04.003.CrossRefPubMed Dijkstra PU, Kalk WW, Roodenburg JL: Trismus in head and neck oncology: a systematic review. Oral Oncol. 2004, 40 (9): 879-889. 10.1016/j.oraloncology.2004.04.003.CrossRefPubMed
40.
go back to reference Johnson J, van As-Brooks CJ, Fagerberg-Mohlin B, Finizia C: Trismus in head and neck cancer patients in Sweden: incidence and risk factors. Med Sci Monit. 2010, 16 (6): CR278-CR282.PubMed Johnson J, van As-Brooks CJ, Fagerberg-Mohlin B, Finizia C: Trismus in head and neck cancer patients in Sweden: incidence and risk factors. Med Sci Monit. 2010, 16 (6): CR278-CR282.PubMed
41.
go back to reference Goldstein M, Maxymiw WG, Cummings BJ, Wood RE: The effects of antitumor irradiation on mandibular opening and mobility: a prospective study of 58 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999, 88 (3): 365-373. 10.1016/S1079-2104(99)70044-2.CrossRefPubMed Goldstein M, Maxymiw WG, Cummings BJ, Wood RE: The effects of antitumor irradiation on mandibular opening and mobility: a prospective study of 58 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999, 88 (3): 365-373. 10.1016/S1079-2104(99)70044-2.CrossRefPubMed
42.
go back to reference Chen WC, Hwang TZ, Wang WH, Lu CH, Chen CC, Chen CM, Weng HH, Lai CH, Chen MF: Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. Oral Oncol. 2009, 45 (6): 505-510. 10.1016/j.oraloncology.2008.07.002.CrossRefPubMed Chen WC, Hwang TZ, Wang WH, Lu CH, Chen CC, Chen CM, Weng HH, Lai CH, Chen MF: Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. Oral Oncol. 2009, 45 (6): 505-510. 10.1016/j.oraloncology.2008.07.002.CrossRefPubMed
43.
go back to reference Gomez DR, Zhung JE, Gomez J, Chan K, Wu AJ, Wolden SL, Pfister DG, Shaha A, Shah JP, Kraus DH, Wong RJ, Lee NY: Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers. Int J Radiat Oncol Biol Phys. 2009, 73 (4): 1096-1103. 10.1016/j.ijrobp.2008.05.024.CrossRefPubMed Gomez DR, Zhung JE, Gomez J, Chan K, Wu AJ, Wolden SL, Pfister DG, Shaha A, Shah JP, Kraus DH, Wong RJ, Lee NY: Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers. Int J Radiat Oncol Biol Phys. 2009, 73 (4): 1096-1103. 10.1016/j.ijrobp.2008.05.024.CrossRefPubMed
44.
go back to reference Hsiung CY, Huang EY, Ting HM, Huang HY: Intensity-modulated radiotherapy for nasopharyngeal carcinoma: the reduction of radiation-induced trismus. Br J Radiol. 2008, 81 (970): 809-814. 10.1259/bjr/17942449.CrossRefPubMed Hsiung CY, Huang EY, Ting HM, Huang HY: Intensity-modulated radiotherapy for nasopharyngeal carcinoma: the reduction of radiation-induced trismus. Br J Radiol. 2008, 81 (970): 809-814. 10.1259/bjr/17942449.CrossRefPubMed
45.
go back to reference Kamstra JI, Roodenburg JL, Beurskens CH, Reintsema H, Dijkstra PU: TheraBite exercises to treat trismus secondary to head and neck cancer. Support Care Cancer. 2013, 21 (4): 951-957. 10.1007/s00520-012-1610-9.PubMedCentralCrossRefPubMed Kamstra JI, Roodenburg JL, Beurskens CH, Reintsema H, Dijkstra PU: TheraBite exercises to treat trismus secondary to head and neck cancer. Support Care Cancer. 2013, 21 (4): 951-957. 10.1007/s00520-012-1610-9.PubMedCentralCrossRefPubMed
46.
go back to reference Hartl DM, Cohen M, Juliéron M, Marandas P, Janot F, Bourhis J: Botulinum toxin for radiation-induced facial pain and trismus. Otolaryngol Head Neck Surg. 2008, 138 (4): 459-463. 10.1016/j.otohns.2007.12.021.CrossRefPubMed Hartl DM, Cohen M, Juliéron M, Marandas P, Janot F, Bourhis J: Botulinum toxin for radiation-induced facial pain and trismus. Otolaryngol Head Neck Surg. 2008, 138 (4): 459-463. 10.1016/j.otohns.2007.12.021.CrossRefPubMed
47.
go back to reference Bhrany AD, Izzard M, Wood AJ, Futran ND: Coronoidectomy for the treatment of trismus in head and neck cancer patients. Laryngoscope. 2007, 117 (11): 1952-1956. 10.1097/MLG.0b013e31812eee13.CrossRefPubMed Bhrany AD, Izzard M, Wood AJ, Futran ND: Coronoidectomy for the treatment of trismus in head and neck cancer patients. Laryngoscope. 2007, 117 (11): 1952-1956. 10.1097/MLG.0b013e31812eee13.CrossRefPubMed
48.
go back to reference Silva AR, Alves FA, Antunes A, Goes MF, Lopes MA: Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res. 2009, 43 (1): 43-49. 10.1159/000192799.CrossRefPubMed Silva AR, Alves FA, Antunes A, Goes MF, Lopes MA: Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res. 2009, 43 (1): 43-49. 10.1159/000192799.CrossRefPubMed
49.
go back to reference Walker MP, Wichman B, Cheng AL, Coster J, Williams KB: Impact of radiotherapy dose on dentition breakdown in head and neck cancer patients. Pract Radiat Oncol. 2011, 1 (3): 142-148. 10.1016/j.prro.2011.03.003.PubMedCentralCrossRefPubMed Walker MP, Wichman B, Cheng AL, Coster J, Williams KB: Impact of radiotherapy dose on dentition breakdown in head and neck cancer patients. Pract Radiat Oncol. 2011, 1 (3): 142-148. 10.1016/j.prro.2011.03.003.PubMedCentralCrossRefPubMed
50.
go back to reference Vissink A, Burlage FR, Spijkervet FK, Jansma J, Coppes RP: Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003, 14 (3): 213-225. 10.1177/154411130301400306.CrossRefPubMed Vissink A, Burlage FR, Spijkervet FK, Jansma J, Coppes RP: Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003, 14 (3): 213-225. 10.1177/154411130301400306.CrossRefPubMed
51.
go back to reference Jansma J, Vissink A, Jongebloed WL, Retief DH, Johannes's-Gravenmade E: Natural and induced radiation caries: A SEM study. Am J Dent. 1993, 6 (3): 130-136.PubMed Jansma J, Vissink A, Jongebloed WL, Retief DH, Johannes's-Gravenmade E: Natural and induced radiation caries: A SEM study. Am J Dent. 1993, 6 (3): 130-136.PubMed
52.
go back to reference Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Luckel H: Radiation-related damage dentition. Lancet Oncol. 2006, 7 (4): 326-335. 10.1016/S1470-2045(06)70658-1.CrossRefPubMed Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Luckel H: Radiation-related damage dentition. Lancet Oncol. 2006, 7 (4): 326-335. 10.1016/S1470-2045(06)70658-1.CrossRefPubMed
53.
go back to reference Franzel W, Gerlach R, Heun HJ, Schaller HG: Effect of tumor therapeutic irradiation on the mechanical properties of teeth tissue. Z Med Phys. 2006, 16 (2): 148-154.CrossRefPubMed Franzel W, Gerlach R, Heun HJ, Schaller HG: Effect of tumor therapeutic irradiation on the mechanical properties of teeth tissue. Z Med Phys. 2006, 16 (2): 148-154.CrossRefPubMed
54.
go back to reference Pioch T, Golfels D, Staehle HJ: An experimental study of the stability of irradiated teeth in the region of the dentinoenamel junction. Endod Dent Traumatol. 1992, 8 (6): 241-244. 10.1111/j.1600-9657.1992.tb00251.x.CrossRefPubMed Pioch T, Golfels D, Staehle HJ: An experimental study of the stability of irradiated teeth in the region of the dentinoenamel junction. Endod Dent Traumatol. 1992, 8 (6): 241-244. 10.1111/j.1600-9657.1992.tb00251.x.CrossRefPubMed
55.
go back to reference Reuther T, Schuster T, Mende U, Kübler A: Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients–a report of a thirty year retrospective review. Int J Oral Maxillofac Surg. 2003, 32 (3): 289-295. 10.1054/ijom.2002.0332.CrossRefPubMed Reuther T, Schuster T, Mende U, Kübler A: Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients–a report of a thirty year retrospective review. Int J Oral Maxillofac Surg. 2003, 32 (3): 289-295. 10.1054/ijom.2002.0332.CrossRefPubMed
56.
go back to reference Marx RE: Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983, 41 (5): 283-288. 10.1016/0278-2391(83)90294-X.CrossRefPubMed Marx RE: Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983, 41 (5): 283-288. 10.1016/0278-2391(83)90294-X.CrossRefPubMed
57.
go back to reference Wong JK, Wood RE, McLean M: Conservative management of osteoradionecrosis. Oral Surg Oral Med Pathol Oral Radiol Endod. 1997, 84 (1): 16-21. 10.1016/S1079-2104(97)90287-0.CrossRef Wong JK, Wood RE, McLean M: Conservative management of osteoradionecrosis. Oral Surg Oral Med Pathol Oral Radiol Endod. 1997, 84 (1): 16-21. 10.1016/S1079-2104(97)90287-0.CrossRef
58.
go back to reference Bras J, de Jonge HK, van Merkesteyn JP: Osteoradionecrosis of the mandible: pathogenesis. Am J Otolaryngol. 1990, 11 (4): 244-250. 10.1016/0196-0709(90)90084-9.CrossRefPubMed Bras J, de Jonge HK, van Merkesteyn JP: Osteoradionecrosis of the mandible: pathogenesis. Am J Otolaryngol. 1990, 11 (4): 244-250. 10.1016/0196-0709(90)90084-9.CrossRefPubMed
59.
go back to reference Thiel HJ: Osteoradionecrosis. I. Etiology, pathogenesis, clinical aspects and risk factors. Radiobiol Radiother (Berl). 1989, 30 (5): 397-413. Thiel HJ: Osteoradionecrosis. I. Etiology, pathogenesis, clinical aspects and risk factors. Radiobiol Radiother (Berl). 1989, 30 (5): 397-413.
60.
go back to reference Regaud C: Sur la necrose des os attente par un processus cancereux et traits par les radiations. Compt Rend Soc Biol. 1922, 87: 629- Regaud C: Sur la necrose des os attente par un processus cancereux et traits par les radiations. Compt Rend Soc Biol. 1922, 87: 629-
61.
go back to reference Marx RE: A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg. 1983, 41 (6): 351-357. 10.1016/S0278-2391(83)80005-6.CrossRefPubMed Marx RE: A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg. 1983, 41 (6): 351-357. 10.1016/S0278-2391(83)80005-6.CrossRefPubMed
62.
go back to reference Epstein JB, Wong FL, Stevenson-Moore P: Osteoradionecrosis: clinical experience and a proposal for classification. J Oral Maxillofac Surg. 1987, 45 (2): 104-110. 10.1016/0278-2391(87)90399-5.CrossRefPubMed Epstein JB, Wong FL, Stevenson-Moore P: Osteoradionecrosis: clinical experience and a proposal for classification. J Oral Maxillofac Surg. 1987, 45 (2): 104-110. 10.1016/0278-2391(87)90399-5.CrossRefPubMed
63.
go back to reference Schwartz HC, Kagan AR: Osteoradionecrosis of the mandible: scientific basis for clinical staging. Am J Clin Oncol. 2002, 25 (2): 168-171. 10.1097/00000421-200204000-00013.CrossRefPubMed Schwartz HC, Kagan AR: Osteoradionecrosis of the mandible: scientific basis for clinical staging. Am J Clin Oncol. 2002, 25 (2): 168-171. 10.1097/00000421-200204000-00013.CrossRefPubMed
64.
go back to reference Støre G, Boysen M: Mandibular osteoradionecrosis: clinical behaviour and diagnostic aspects. Clin Otolaryngol Allied Sci. 2000, 25 (5): 378-384. 10.1046/j.1365-2273.2000.00367.x.CrossRefPubMed Støre G, Boysen M: Mandibular osteoradionecrosis: clinical behaviour and diagnostic aspects. Clin Otolaryngol Allied Sci. 2000, 25 (5): 378-384. 10.1046/j.1365-2273.2000.00367.x.CrossRefPubMed
65.
go back to reference Wahl MJ: Osteoradionecrosis prevention myths. Int J Radiat Oncol Biol Phys. 2006, 64 (3): 661-669. 10.1016/j.ijrobp.2005.10.021.CrossRefPubMed Wahl MJ: Osteoradionecrosis prevention myths. Int J Radiat Oncol Biol Phys. 2006, 64 (3): 661-669. 10.1016/j.ijrobp.2005.10.021.CrossRefPubMed
66.
go back to reference Ahmed M, Hansen VN, Harrington KJ, Nutting CM: Reducing the risk of xerostomia and mandibular osteoradionecrosis: the potential benefit of intensity modulated radiotherapy in advanced oral cavity carcinoma. Med Dosim. 2009, 34 (3): 217-224. 10.1016/j.meddos.2008.08.008.CrossRefPubMed Ahmed M, Hansen VN, Harrington KJ, Nutting CM: Reducing the risk of xerostomia and mandibular osteoradionecrosis: the potential benefit of intensity modulated radiotherapy in advanced oral cavity carcinoma. Med Dosim. 2009, 34 (3): 217-224. 10.1016/j.meddos.2008.08.008.CrossRefPubMed
67.
go back to reference Chang DT, Sandow PR, Morris CG, Hollander R, Scarborough L, Amdur RJ, Mendenhall WM: Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?. Head Neck. 2007, 29 (6): 528-536. 10.1002/hed.20538.CrossRefPubMed Chang DT, Sandow PR, Morris CG, Hollander R, Scarborough L, Amdur RJ, Mendenhall WM: Do pre-irradiation dental extractions reduce the risk of osteoradionecrosis of the mandible?. Head Neck. 2007, 29 (6): 528-536. 10.1002/hed.20538.CrossRefPubMed
68.
go back to reference Starcke EN, Shannon IL: How critical is the interval between extractions and irradiation in patients with head and neck malignancy?. Oral Surg Oral Med Oral Pathol. 1997, 43 (3): 333-337. 10.1016/0030-4220(77)90317-6.CrossRef Starcke EN, Shannon IL: How critical is the interval between extractions and irradiation in patients with head and neck malignancy?. Oral Surg Oral Med Oral Pathol. 1997, 43 (3): 333-337. 10.1016/0030-4220(77)90317-6.CrossRef
69.
go back to reference Anderson L, Meraw S, Al-Hezaimi K, Wang HL: The influence of radiation therapy on dental implantology. Implant Dent. 2013, 22 (1): 31-38. 10.1097/ID.0b013e31827e84ee.CrossRefPubMed Anderson L, Meraw S, Al-Hezaimi K, Wang HL: The influence of radiation therapy on dental implantology. Implant Dent. 2013, 22 (1): 31-38. 10.1097/ID.0b013e31827e84ee.CrossRefPubMed
70.
go back to reference Delanian S, Depondt J, Lefaix JL: Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head Neck. 2005, 27 (2): 114-123. 10.1002/hed.20121.CrossRefPubMed Delanian S, Depondt J, Lefaix JL: Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head Neck. 2005, 27 (2): 114-123. 10.1002/hed.20121.CrossRefPubMed
71.
go back to reference Annane D, Depondt J, Aubert P, Villart M, Géhanno P, Gajdos P, Chevret S: Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol. 2004, 22 (24): 4893-4900. 10.1200/JCO.2004.09.006.CrossRefPubMed Annane D, Depondt J, Aubert P, Villart M, Géhanno P, Gajdos P, Chevret S: Hyperbaric oxygen therapy for radionecrosis of the jaw: a randomized, placebo-controlled, double-blind trial from the ORN96 study group. J Clin Oncol. 2004, 22 (24): 4893-4900. 10.1200/JCO.2004.09.006.CrossRefPubMed
Metadata
Title
Treatment improvement and better patient care: which is the most important one in oral cavity cancer?
Authors
Francesca De Felice
Daniela Musio
Valentina Terenzi
Valentino Valentini
Andrea Cassoni
Mario Tombolini
Marco De Vincentiis
Vincenzo Tombolini
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2014
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-014-0263-x

Other articles of this Issue 1/2014

Radiation Oncology 1/2014 Go to the issue