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Oral and Maxillofacial Surgery
Published in: Oral and Maxillofacial Surgery 1/2008

01-05-2008 | Original Article

Treatment for lung metastasis from head and neck squamous cell carcinoma: a preliminary study of docetaxel

Authors: Kenji Yamagata, Kojiro Onizawa, Yuki Otsuka, Hiroshi Yoshida

Published in: Oral and Maxillofacial Surgery | Issue 1/2008

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Abstract

Objectives

The aims of the study were to investigate the prognosis of patients with lung metastasis after treatment for head and neck squamous cell carcinoma (HANSCC) and to preliminarily evaluate the efficacy and toxicity of docetaxel (DOC)-based chemotherapy.

Materials and methods

The effectiveness of the chemotherapy was evaluated retrospectively according to the tumor response rate and survival time post-metastasis. Thirty patients were enrolled in the study. Twenty-seven have died, two are living, and one was lost during follow-up. Nineteen patients were treated for lung metastasis with chemotherapy. DOC-based chemotherapy was given to seven patients and non-DOC-based chemotherapy to 12.

Results and discussion

The response rate was 28.6% for the first administration of DOC-based chemotherapy, but only 8.3% for the non-DOC-based chemotherapy. Thus, DOC-based chemotherapy had a better response rate for lung metastases than other chemotherapy agents tested. Although the sample size was small, DOC seems to shrink or inhibit the growth of lung metastases in patients with primary HANSCC.
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Metadata
Title
Treatment for lung metastasis from head and neck squamous cell carcinoma: a preliminary study of docetaxel
Authors
Kenji Yamagata
Kojiro Onizawa
Yuki Otsuka
Hiroshi Yoshida
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Oral and Maxillofacial Surgery / Issue 1/2008
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-008-0100-1

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