Top

Published in:

Open Access 01-12-2011 | Short report

Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6

Authors: Meng Zhefeng, Hu Huiliang, Qiu Chao, Sun Jun, Lu Jianxin, Zhang Xiaoyan, Xu Jianqing

Published in: Virology Journal | Issue 1/2011

Abstract

A 7 amino acid deletion in Gag p6 (P6delta7) emerged in Chinese prevalent HIV-1 strain CRF07_BC from different epidemic regions. It is important to determine whether this mutation could be transmitted and spread. In this study, HIV-1 Gag sequences from 5 different epidemic regions in China were collected to trace the transmission linkage and to analyze genetic evolution of P6delta7 strains. The sequence analysis demonstrated that P6delta7 is a CRF07_BC specific deletion, different P6delta7 strains could be originated from different parental CRF07_BC recombinants in different epidemic regions, and the transmission of P6delta7 strain has occurred in IDU populations. This is for the first time to identify the transmission linkage for P6delta7 strains and serves as a wake-up call for further monitoring in the future; In addition, P6delta7 deletion may represent an evolutionary feature which might exert influence on the fitness of CRF07_BC strain.

Available only for authorised users

Coren LV, Thomas JA, Chertova E, Sowder RC, Gagliardi TD, Gorelick RJ, Ott DE: Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1. J Virol 2007, 81: 10047-10054. 10.1128/JVI.02496-06PubMedCentralCrossRefPubMed

Pikora CA, Wittish C, Desrosiers RC: p6 gag of human and simian immunodeficiency viruses is tolerant to small in-frame deletions downstream of the late domain. Virology 2006, 346: 479-489. 10.1016/j.virol.2005.10.040CrossRefPubMed

Bleiber G, Peters S, Martinez R, Cmarko D, Meylan P, Telenti A: The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro. J Gen Virol 2004, 85: 921-927. 10.1099/vir.0.19576-0CrossRefPubMed

Yan-Hui Song, ZheFeng Meng, Xing Hui, Yuhua Ruan, Xinping Li, Ruolei Xin, Pengfei Ma, Peng Hong, Shao Yiming: Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6. Arch Virol 2007, 26: 1553-1558.

Wang L: Overview of the HIV/AIDS epidemic, scientific research and government responses in China. AIDS 2007,21(Suppl 8):S3-7. 10.1097/01.aids.0000304690.24390.c2CrossRefPubMed

Zhang KL, Ma SJ: Epidemiology of HIV in China[letter]. BMJ 2002, 324: 803-804. 10.1136/bmj.324.7341.803PubMedCentralCrossRef

Lin YT, Lan YC, Chen YJ: Molecular epidemiology of HIV-1 infection and full-length genomic analysis of circulating recombinant form 07_BC strains from injection drug users in Taiwan. J Infect Dis 2007, 195: 1283-1293. 10.1086/513437CrossRefPubMed

Piyasirisilp S, McCutchan FE, Carr JK, Sanders-Buell E, Liu W, Chen J, Wagner R, Wolf H, Shao Y, Lai S, Beyrer C, Yu XF: A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol 2000, 74: 11286-11295. 10.1128/JVI.74.23.11286-11295.2000PubMedCentralCrossRefPubMed

Jia M, Luo H, Ma Y, Wang N, Smith K, Mei J, Lu R, Lu J, Fu L, Zhang Q, Wu Z, Lu L: The HIV epidemic in Yunnan Province, China, 1989-2007. J Acquir Immune Defic Syndr 2010,539(Suppl 1):S34-40.CrossRef

10.

Posada D, Buckley TR: Model selection and model averaging in phylogenetics: advantages of the AIC and Bayesian approaches over likelihood ratio tests. Systematic Biology 2004, 53: 793-808. 10.1080/10635150490522304CrossRefPubMed

11.

Paraskevis D, Magiorkinis E, Magiorkinis G, Kiosses VG, Lemey P, Vandamme AM, Rambaut A, Hatzakis A: Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods. J Mol Evol 2004, 59: 709-717. 10.1007/s00239-004-2651-6CrossRefPubMed

12.

Shimodaira H, Hasegawa M: CONSEL: for assessing the confidence of phylogenetic tree selection. Bioinformatics 2001, 17: 1246-1247. 10.1093/bioinformatics/17.12.1246CrossRefPubMed

13.

Resik Sonia, Lemey Philippe, Ping Li-hua, Kouri Vivian, Joanes Jose, Pérez Jorge, Vandamme AM, Swanstrom R: Limitations to Contact Tracing and Phylogenetic Analysis in Establishing HIV Type 1 Transmission Networks in Cuba. AIDS Res Hum Retroviruses 2007, 23: 347-356. 10.1089/aid.2006.0158CrossRefPubMed

14.

Yang Z, Rananala B: Bayesian phylogenetic inference using DNA sequences: A Markov Chain Monte Carlo method. Mol Biol Evol 1997, 14: 717-724.CrossRefPubMed

15.

Lazert C, Chazal N, Briant L, Gerlier D, Cortay JC: Refined study of the interaction between HIV-1 p6 late domain and ALIX. Retrovirology 2008, 13: 39. 10.1186/1742-4690-5-39CrossRef

16.

Dussupt V, Javid MP, Abou-Jaoudé G, Jadwin JA, de La Cruz J, Nagashima K, Bouamr F: The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. PLoS Pathog 2009, 5: e1000339. 10.1371/journal.ppat.1000339PubMedCentralCrossRefPubMed

17.

Strack B, Calistri A, Craig S, Popova E, Göttlinger HG: AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell 2003, 114: 689-699. 10.1016/S0092-8674(03)00653-6CrossRefPubMed

18.

Fisher RD, Chung HY, Zhai Q, Robinson H, Sundquist WI, Hill CP: Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell 2007, 128: 841-852. 10.1016/j.cell.2007.01.035CrossRefPubMed

Title: Transmission of new CRF07_BC Strains with 7 amino acid deletion in Gag p6
Authors: Meng Zhefeng
Hu Huiliang
Qiu Chao
Sun Jun
Lu Jianxin
Zhang Xiaoyan
Xu Jianqing
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2011
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-8-60

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2011

Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010

Isolation and characterization of a novel alphanodavirus

Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

Outbreak of pandemic influenza A/H1N1 2009 in Nepal

Isolation, identification, and complete genome sequence of a bovine adenovirus type 3 from cattle in China

RNA interference-based resistance against a legume mastrevirus

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials