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BMC Proceedings
Published in: BMC Proceedings 9/2018

Open Access 01-09-2018 | Proceedings

Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood

Authors: Hemant Kulkarni, Indranil Mukhopadhyay, Saurabh Ghosh

Published in: BMC Proceedings | Special Issue 9/2018

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Abstract

Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead to increased power in detecting genetic association. In this paper, we extend a transmission-based association test applying quasi-likelihood that has been developed by us to the longitudinal framework and to carry out a genome-wide association analysis of triglyceride levels based on the data provided in GAW20. We consider different phenotype definitions based on administration of fenofibrate and obtain significant association findings within genes involved in heart diseases.
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Metadata
Title
Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
Authors
Hemant Kulkarni
Indranil Mukhopadhyay
Saurabh Ghosh
Publication date
01-09-2018
Publisher
BioMed Central
Published in
BMC Proceedings / Issue Special Issue 9/2018
Electronic ISSN: 1753-6561
DOI
https://doi.org/10.1186/s12919-018-0147-4

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