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Head and Neck Pathology
Published in: Head and Neck Pathology 2/2007

01-12-2007 | Case Report

Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

Authors: Diana Bell, Yi-Jue Zhao, Pulivarthi H. Rao, Randal S. Weber, Adel K. El-Naggar

Published in: Head and Neck Pathology | Issue 2/2007

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Abstract

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.
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Metadata
Title
Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue
Authors
Diana Bell
Yi-Jue Zhao
Pulivarthi H. Rao
Randal S. Weber
Adel K. El-Naggar
Publication date
01-12-2007
Publisher
Humana Press Inc
Published in
Head and Neck Pathology / Issue 2/2007
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-007-0030-5

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