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European Journal of Trauma and Emergency Surgery

Published in:

01-10-2018 | Editorial

Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?

Authors: Paolo Cinelli, Katrin Rauen, Sascha Halvazishadeh, Hans Christoph Pape

Published in: European Journal of Trauma and Emergency Surgery | Issue 5/2018

Excerpt

Along with the development of sophisticated methods to assess parameters in experimental animal and laboratory studies, the meaningfulness of these studies has increased. Clinical studies alone may be difficult to obtain [1, 2] and patient numbers may represent an issue [3]. This may get to a point where research organizations stop providing the financial support if the patient numbers are not met on time [4]. Other publications provide subsets of data studies that may suffer from type II errors and lack of long-term impact [5, 6] (Table 1). …

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Pfeifer R, Kobbe P, Darwiche SS, Billiar TR, Pape HC. Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock. J Orthop Res. 2011;29(2):270–4.CrossRefPubMed

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Kobbe P, Vodovotz Y, Kaczorowski DJ, Mollen KP, Billiar TR, Pape HC. Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock. 2008;30(1):43–47.CrossRefPubMed

17.

Kobbe P, Vodovotz Y, Kaczorowski DJ, Billiar TR, Pape HC. The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. J Orthop Trauma. 2008;22(6):385–90.CrossRefPubMed

18.

Kalbitz M, Schwarz S, Weber B, Bosch B, Pressmar J, Hoenes FM, Braun CK, Horst K, Simon TP, Pfeifer R, Störmann P, Hummler H, Gebhard F, Pape HC, Huber-Lang M, Hildebrand F, TREAT Research Group. Cardiac depression in pigs after multiple trauma—characterization of posttraumatic structural and functional alterations. Sci Rep. 2017;7(1):17861. https://doi.org/10.1038/s41598-017-18088-1.CrossRefPubMedPubMedCentral

19.

Qiao Z, Horst K, Teuben M, Greven J, Yin L, Kalbas Y, Tolba RH, Pape HC, Hildebrand F, Pfeifer R. TREAT group. Analysis of skeletal muscle microcirculation in a porcine polytrauma model with haemorrhagic shock. J Orthop Res. 2018;36(5):1377–82. https://doi.org/10.1002/jor.23759. (epub 2018).CrossRefPubMed

20.

Schimunek L, Serve R, Teuben MPJ, Störmann P, Auner B, Woschek M, Pfeifer R, Horst K, Simon TP, Kalbitz M, Sturm R, Pape HC, Hildebrand F, Marzi I, Relja B. Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model. PLoS One 2017;12(11):e0187404. https://doi.org/10.1371/journal.pone.0187404.CrossRefPubMedPubMedCentral

21.

Eschbach D, Horst K, Sassen M, Andruszkow J, Mohr J, Debus F, Vogt N, Steinfeldt T, Hildebrand F, Schöller K, Uhl E, Wulf H, Ruchholtz S, Pape H, Frink M. Hypothermia does not influence liver damage and function in a porcine polytrauma model. Technol Health Care 2018;26(2):209–21. https://doi.org/10.3233/THC-171043.CrossRefPubMed

22.

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23.

Greven J, Pfeifer R, Zhi Q, Pape HC. Update on the role of endothelial cells in trauma. Eur J Trauma Emerg Surg. 2017. https://doi.org/10.1007/s00068-017-0812-8.CrossRefPubMed

24.

Qiao Z, Wang W, Yin L, Luo P, Greven J, Horst K, Hildebrand F. Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients: a meta-analysis. Eur J Trauma Emerg Surg. 2017. https://doi.org/10.1007/s00068-017-0880-9.CrossRefPubMed

25.

Kalbas Y, Qiao Z, Horst K, Teuben M, Tolba RH, Hildebrand F, Pape H-C, Pfeifer R; TREAT Research Group. Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture. Eur J Trauma Emerg Surg. 2018. https://doi.org/10.1007/s00068-018-0991-y.CrossRefPubMed

Title: Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?
Authors: Paolo Cinelli
Katrin Rauen
Sascha Halvazishadeh
Hans Christoph Pape
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Trauma and Emergency Surgery / Issue 5/2018
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-018-1003-y

At a glance: The STEP trials

Springer Medicine

Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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