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Neuroradiology

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01-07-2006 | Diagnostic Neuroradiology

Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis

Authors: M. Nelles, C. G. Bien, M. Kurthen, M. von Falkenhausen, H. Urbach

Published in: Neuroradiology | Issue 7/2006

Abstract

Introduction

Transient splenium corporis callosi (SCC) lesions are related to rapid reduction of antiepileptic drugs (AEDs). The range of substances with predilection for SCC changes, their pathophysiology and their occurrence are still unknown.

Methods

In a prospective 2-year study an epilepsy-dedicated MRI protocol supplemented by DWI and ADC maps was performed after AED withdrawal for diagnostic seizure provocation in all patients with pharmacoresistant seizures locally admitted to the Department of Epileptology.

Results

Of 891 presurgical epilepsy patients, 6 (0.7%) had SCC lesions with cytotoxic edema on DWI. Carbamazepine combined with other AEDs was administered in five of those patients. In the study period we observed identical lesions in a schizophrenic patient treated with olanzapine and citalopram, in a patient with oropharyngeal carcinoma treated with alkylating agents, and in a hypernatremic patient following neurohypophyseal granular cell tumor surgery.

Conclusion

Transient SCC lesions are related to rapid AED reduction but may occur in similar conditions with fluid balance alterations. We contribute further clinical data in this field to better classify the pharmaceuticals that are prone to the described cerebral cytotoxic side effects in the SCC and to clarify their incidence among presurgical epilepsy patients.

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Title: Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis
Authors: M. Nelles
C. G. Bien
M. Kurthen
M. von Falkenhausen
H. Urbach
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 7/2006
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-006-0080-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Transient splenium lesions in presurgical epilepsy patients: incidence and pathogenesis

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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