Skip to main content
Top
Published in: European Journal of Pediatrics 9/2010

01-09-2010 | Short Report

Transient hepatitis B surface antigen circulation after Infanrix-Hexa®: a case report and review of the literature

Authors: Elpis Mantadakis, Stavros Thomaidis, Eugnosia-Nektaria Efraimidou, Anna Ramatani, Athanassios Chatzimichael

Published in: European Journal of Pediatrics | Issue 9/2010

Login to get access

Abstract

The authors describe the case of a 70-day-old boy who was mistakenly diagnosed as suffering from acute hepatitis B, when he presented with persistent unconjugated hyperbilirubinemia and transaminasemia and was found to be seropositive for the hepatitis B surface antigen. The antigenemia was transient and related to his recent immunization with Infanrix-Hexa®. Caution is required during interpretation of a positive HBsAg test that is obtained within 28 days after vaccination against hepatitis B.
Literature
1.
go back to reference Bernstein SR, Krieger P, Puppala BL, Costello M (1994) Incidence and duration of hepatitis B surface antigenemia after neonatal hepatitis B immunization. J Pediatr 125:621–622CrossRefPubMed Bernstein SR, Krieger P, Puppala BL, Costello M (1994) Incidence and duration of hepatitis B surface antigenemia after neonatal hepatitis B immunization. J Pediatr 125:621–622CrossRefPubMed
2.
go back to reference Challapalli M, Naidu V, Cunningham DG (1993) Hepatitis B surface antigenemia in a newborn infant after vaccination. Pediatr Infect Dis J 12:408–409CrossRefPubMed Challapalli M, Naidu V, Cunningham DG (1993) Hepatitis B surface antigenemia in a newborn infant after vaccination. Pediatr Infect Dis J 12:408–409CrossRefPubMed
3.
go back to reference Challapalli M, Slosar M, Vasa R, Cunningham DG (1993) Brief surface antigenemia in newborn infants vaccinated with hepatitis B vaccine. Pediatr Infect Dis J 12:878–879CrossRefPubMed Challapalli M, Slosar M, Vasa R, Cunningham DG (1993) Brief surface antigenemia in newborn infants vaccinated with hepatitis B vaccine. Pediatr Infect Dis J 12:878–879CrossRefPubMed
4.
go back to reference De Schryver A, De Gendt K, François G, Van Damme P, Meheus A (2004) Hepatitis B surface antigenaemia following vaccination with a combined vaccine against hepatitis A and B. J Viral Hepat 11:88–90CrossRefPubMed De Schryver A, De Gendt K, François G, Van Damme P, Meheus A (2004) Hepatitis B surface antigenaemia following vaccination with a combined vaccine against hepatitis A and B. J Viral Hepat 11:88–90CrossRefPubMed
5.
go back to reference Dow BC, Yates P, Galea G, Munro H, Buchanan I, Ferguson K (2002) Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen-positive blood donors. Vox Sang 82:15–17CrossRefPubMed Dow BC, Yates P, Galea G, Munro H, Buchanan I, Ferguson K (2002) Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen-positive blood donors. Vox Sang 82:15–17CrossRefPubMed
6.
go back to reference Fleischer L, Syed SS (2009) Hepatitis B surface antigenemia in a neonate following vaccination with Pediarix. Clin Pediatr (Phila) 48:311–312CrossRef Fleischer L, Syed SS (2009) Hepatitis B surface antigenemia in a neonate following vaccination with Pediarix. Clin Pediatr (Phila) 48:311–312CrossRef
7.
go back to reference Greenberg DP (1993) Pediatric experience with recombinant hepatitis vaccines and relevant safety and immunogenicity studies. Pediatr Infect Dis J 12:438–445CrossRefPubMed Greenberg DP (1993) Pediatric experience with recombinant hepatitis vaccines and relevant safety and immunogenicity studies. Pediatr Infect Dis J 12:438–445CrossRefPubMed
8.
go back to reference Janzen L, Minuk GY, Fast M, Bernstein KN (1996) Vaccine-induced hepatitis B surface antigen positivity in adult hemodialysis patients: incidental and surveillance data. J Am Soc Nephrol 7:1228–1234PubMed Janzen L, Minuk GY, Fast M, Bernstein KN (1996) Vaccine-induced hepatitis B surface antigen positivity in adult hemodialysis patients: incidental and surveillance data. J Am Soc Nephrol 7:1228–1234PubMed
9.
go back to reference Jorgensen MH, Ott P, Juul A, Skakkebaek NE, Michaelsen KF (2003) Does breast feeding influence liver biochemistry? J Pediatr Gastroenterol Nutr 37:559–565CrossRefPubMed Jorgensen MH, Ott P, Juul A, Skakkebaek NE, Michaelsen KF (2003) Does breast feeding influence liver biochemistry? J Pediatr Gastroenterol Nutr 37:559–565CrossRefPubMed
10.
go back to reference Kloster B, Kramer R, Eastlund T, Grossman B, Zarvan B (1995) Hepatitis B surface antigenemia in blood donors following vaccination. Transfusion 35:475–477CrossRefPubMed Kloster B, Kramer R, Eastlund T, Grossman B, Zarvan B (1995) Hepatitis B surface antigenemia in blood donors following vaccination. Transfusion 35:475–477CrossRefPubMed
11.
go back to reference Köksal N, Altinkaya N, Perk Y (1996) Transient hepatitis B surface antigenemia after neonatal hepatitis B immunization. Acta Paediatr 85:1501–1502CrossRefPubMed Köksal N, Altinkaya N, Perk Y (1996) Transient hepatitis B surface antigenemia after neonatal hepatitis B immunization. Acta Paediatr 85:1501–1502CrossRefPubMed
12.
go back to reference Ly D, Yee HF Jr, Brezina M, Martin P, Gitnick G, Saab S (2002) Hepatitis B surface antigenemia in chronic hemodialysis patients: effect of hepatitis B immunization. Am J Gastroenterol 97:138–141CrossRefPubMed Ly D, Yee HF Jr, Brezina M, Martin P, Gitnick G, Saab S (2002) Hepatitis B surface antigenemia in chronic hemodialysis patients: effect of hepatitis B immunization. Am J Gastroenterol 97:138–141CrossRefPubMed
13.
go back to reference Otağ F, Mert A, Yilmaz G (1997) Temporary deferral of blood donors after administration of hepatitis B vaccine. Transfusion 37:880PubMed Otağ F, Mert A, Yilmaz G (1997) Temporary deferral of blood donors after administration of hepatitis B vaccine. Transfusion 37:880PubMed
14.
go back to reference Shepard CW, Finelli L, Fiore AE, Bell BP (2005) Epidemiology of hepatitis B and hepatitis B virus infection in United States children. Pediatr Infect Dis J 24:755–760CrossRefPubMed Shepard CW, Finelli L, Fiore AE, Bell BP (2005) Epidemiology of hepatitis B and hepatitis B virus infection in United States children. Pediatr Infect Dis J 24:755–760CrossRefPubMed
15.
go back to reference Weintraub Z, Khamaysi N, Elena H, Gershtein V, Orenstein L, Lahat N (1994) Transient surface antigenemia in newborn infants vaccinated with Engerix B: occurrence and duration. Pediatr Infect Dis J 13:931–933CrossRefPubMed Weintraub Z, Khamaysi N, Elena H, Gershtein V, Orenstein L, Lahat N (1994) Transient surface antigenemia in newborn infants vaccinated with Engerix B: occurrence and duration. Pediatr Infect Dis J 13:931–933CrossRefPubMed
Metadata
Title
Transient hepatitis B surface antigen circulation after Infanrix-Hexa®: a case report and review of the literature
Authors
Elpis Mantadakis
Stavros Thomaidis
Eugnosia-Nektaria Efraimidou
Anna Ramatani
Athanassios Chatzimichael
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 9/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-010-1146-2

Other articles of this Issue 9/2010

European Journal of Pediatrics 9/2010 Go to the issue