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Journal of Mammary Gland Biology and Neoplasia
Published in: Journal of Mammary Gland Biology and Neoplasia 2/2009

01-06-2009

Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression

Authors: Kathleen C. Flanders, Lalage M. Wakefield

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2009

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Abstract

During rodent mammary gland involution there is a dramatic increase in the expression of the transforming growth factor-β isoform, TGF-β3. The TGF-βs are multifunctional cytokines which play important roles in wound healing and in carcinogenesis. The responses that are activated in the remodeling of the gland during involution have many similarities with the wound healing process and have been postulated to generate a mammary stroma that provides a microenvironment favoring tumor progression. In this review we will discuss the putative role of TGF-β during involution, as well as its effects on the mammary microenvironment and possible implications for pregnancy-associated tumorigenesis.
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Metadata
Title
Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression
Authors
Kathleen C. Flanders
Lalage M. Wakefield
Publication date
01-06-2009
Publisher
Springer US
Published in
Journal of Mammary Gland Biology and Neoplasia / Issue 2/2009
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-009-9122-z

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