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01-12-2013 | Case Report

Transformation of a giant cell tumor of bone into a secondary malignant fibrous histiocytoma

Authors: J. Bruns, O. Yazigee, G. Delling, W. Fiedler, C. H. Lohmann, W. Rüther

Published in: European Orthopaedics and Traumatology | Issue 4/2013

Excerpt

Spontaneous malignant transformation of giant cell tumor (GCT) of the bone is not uncommon [6, 7, 9‐11, 29]. Malignant transformation has been defined by many authors as a sarcoma associated with a benign typical GCT at presentation or as a sarcoma arising at the site of a preexisting GCT [6, 11] resulting in osteosarcoma, fibrosarcoma, or malignant histiocytoma [5, 31]. Many authors have reported a strong association between preventive radiation therapy in the treatment of GCT and secondary malignant transformation of the GCT [6, 8, 11, 23, 28, 37] and/or after several local recurrences of GCT [15, 18, 19]. However, malignant transformation without association to radiation therapy has also been reported [5, 8]. We report a case of GCT with transformation into a secondary malignant fibrous histiocytoma that developed after local GCT recurrence and had no association to adjuvant radiation therapy. …

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Title: Transformation of a giant cell tumor of bone into a secondary malignant fibrous histiocytoma
Authors: J. Bruns
O. Yazigee
G. Delling
W. Fiedler
C. H. Lohmann
W. Rüther
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: European Orthopaedics and Traumatology / Issue 4/2013
Print ISSN: 1867-4569
Electronic ISSN: 1867-4577
DOI: https://doi.org/10.1007/s12570-013-0179-1

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Transformation of a giant cell tumor of bone into a secondary malignant fibrous histiocytoma

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