Skip to main content
Top
Published in: Archives of Women's Mental Health 2/2016

01-04-2016 | Short Communication

Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations

Authors: Emily Pinheiro, Debra L. Bogen, Denada Hoxha, Katherine L. Wisner

Published in: Archives of Women's Mental Health | Issue 2/2016

Login to get access

Abstract

We examined estradiol (E2) and estrone (E1) concentrations in breastfeeding mother-infant dyads. The mothers had postpartum depression and were participants in a randomized clinical trial with three treatments (transdermal E2, sertraline, and placebo). Neither infant E1 and E2 concentrations nor infant growth differed across the treatments. Transdermal E2 administration of 50 to 200 mcg/day for breastfeeding women did not affect infant E1 or E2 concentrations or infant growth.
Literature
go back to reference Ahokas A, Kaukoranta J, Wahlbeck K, Aito M (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J Clin Psychiatry 62:332–336CrossRefPubMed Ahokas A, Kaukoranta J, Wahlbeck K, Aito M (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J Clin Psychiatry 62:332–336CrossRefPubMed
go back to reference Ball DE, Morrison P (1999) Oestrogen transdermal patches for post partum depression in lactating mothers—a case report. Cent Afr J Med 45:68–70PubMed Ball DE, Morrison P (1999) Oestrogen transdermal patches for post partum depression in lactating mothers—a case report. Cent Afr J Med 45:68–70PubMed
go back to reference Gregoire A, Kumar R, Everitt B, Studd J (1996) Transdermal oestrogen for treatment of severe postnatal depression. Lancet 347:930–933CrossRefPubMed Gregoire A, Kumar R, Everitt B, Studd J (1996) Transdermal oestrogen for treatment of severe postnatal depression. Lancet 347:930–933CrossRefPubMed
go back to reference Illingworth PJ, Seaton JE, McKinlay C, Reid-Thomas V, McNeilly AS (1995) Low dose transdermal oestradiol suppresses gonadotrophin secretion in breast-feeding women. Hum Reprod 10:1671–1677PubMed Illingworth PJ, Seaton JE, McKinlay C, Reid-Thomas V, McNeilly AS (1995) Low dose transdermal oestradiol suppresses gonadotrophin secretion in breast-feeding women. Hum Reprod 10:1671–1677PubMed
go back to reference Lawrence RA, Lawrence RM (2010) Physiology of lactation breastfeeding: a guide for the medical professional (Seventh ed.). MO: Elsevier, Maryland Heights Lawrence RA, Lawrence RM (2010) Physiology of lactation breastfeeding: a guide for the medical professional (Seventh ed.). MO: Elsevier, Maryland Heights
go back to reference Nilsson S, Nygren KG, Johansson ED (1978) Transfer of estradiol to human milk. Am J Obstet Gynecol 132:653–657PubMed Nilsson S, Nygren KG, Johansson ED (1978) Transfer of estradiol to human milk. Am J Obstet Gynecol 132:653–657PubMed
go back to reference Perheentupa A, Critchley HO, Illingworth PJ, McNeilly AS (2000) Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab 85:4280–4286CrossRefPubMed Perheentupa A, Critchley HO, Illingworth PJ, McNeilly AS (2000) Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab 85:4280–4286CrossRefPubMed
go back to reference Perheentupa A, Ruokonen A, Tapanainen JS (2004) Transdermal estradiol treatment suppresses serum gonadotropins during lactation without transfer into breast milk. Fertil Steril 82:903–907CrossRefPubMed Perheentupa A, Ruokonen A, Tapanainen JS (2004) Transdermal estradiol treatment suppresses serum gonadotropins during lactation without transfer into breast milk. Fertil Steril 82:903–907CrossRefPubMed
go back to reference Westhoff CL, Torgal AT, Mayeda ER, Shimoni N, Stanczyk FZ, Pike MC (2012) Predictors of noncompliance in an oral contraceptive clinical trial. Contraception 85:465–469CrossRefPubMed Westhoff CL, Torgal AT, Mayeda ER, Shimoni N, Stanczyk FZ, Pike MC (2012) Predictors of noncompliance in an oral contraceptive clinical trial. Contraception 85:465–469CrossRefPubMed
go back to reference Wisner KL, Sit DKY, Moses-Kolko EL, Driscoll KE, Prairie B, Stika CS, Eng HF, Dills JL, Luther JF, Wisniewski SR (2015) Transdermal Estradiol Treatment for Postpartum Depression: A Pilot Randomized Trial. Journal of Clinical Psychopharmacology (in press) Wisner KL, Sit DKY, Moses-Kolko EL, Driscoll KE, Prairie B, Stika CS, Eng HF, Dills JL, Luther JF, Wisniewski SR (2015) Transdermal Estradiol Treatment for Postpartum Depression: A Pilot Randomized Trial. Journal of Clinical Psychopharmacology (in press)
go back to reference Zieman M, Guillebaud J, Weisberg E, Shangold GA, Fisher AC, Creasy GW (2002) Contraceptive efficacy and cycle control with the Ortho Evra™/Evra™ transdermaxl system: the analysis of pooled data. Fertil Steril 77:13–18CrossRef Zieman M, Guillebaud J, Weisberg E, Shangold GA, Fisher AC, Creasy GW (2002) Contraceptive efficacy and cycle control with the Ortho Evra™/Evra™ transdermaxl system: the analysis of pooled data. Fertil Steril 77:13–18CrossRef
Metadata
Title
Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations
Authors
Emily Pinheiro
Debra L. Bogen
Denada Hoxha
Katherine L. Wisner
Publication date
01-04-2016
Publisher
Springer Vienna
Published in
Archives of Women's Mental Health / Issue 2/2016
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI
https://doi.org/10.1007/s00737-015-0532-1

Other articles of this Issue 2/2016

Archives of Women's Mental Health 2/2016 Go to the issue