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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2020

Open Access 01-12-2020 | Endometriosis | Review

Biogenesis and functions of circular RNAs and their role in diseases of the female reproductive system

Authors: Yalan Ma, Ying Xu, Jingshun Zhang, Lianwen Zheng

Published in: Reproductive Biology and Endocrinology | Issue 1/2020

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Abstract

A member of the newly discovered RNA family, circular RNA (circRNA) is considered as the intermediate product of by-product splicing or abnormal RNA splicing. With the development of RNA sequencing, circRNA has recently drawn research interest. CircRNA exhibits stability, species conservatism, and tissue cell specificity. It acts as a miRNA sponge in the circRNA-microRNA (miRNA-mRNA axis, which can regulate gene transcription and protein translation. Studies have confirmed that circRNA is ubiquitous in eukaryotic cells, which play an important role in the regulation of human gene expression and participate in the occurrence and development of various human diseases. CircRNA may be closely related to the occurrence and development of female reproductive system diseases. By analyzing the biological functions and mechanism of circRNA, we find that circRNA has certain development prospects as biomarkers of the female reproductive system diseases. The production and degradation of circRNA, biological functions, and their association with the occurrence of diseases of female reproductive system are reviewed in this article.
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Metadata
Title
Biogenesis and functions of circular RNAs and their role in diseases of the female reproductive system
Authors
Yalan Ma
Ying Xu
Jingshun Zhang
Lianwen Zheng
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Endometriosis
Published in
Reproductive Biology and Endocrinology / Issue 1/2020
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-020-00653-5

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