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01-06-2011 | Letter

How to assess the dangers of hyperoxemia: methodological issues

Authors: B Ronan O'Driscoll, Luke S Howard

Published in: Critical Care | Issue 3/2011

Excerpt

We read with interest the paper by Bellomo and colleagues [1] in the previous issue of Critical Care. We agree with the authors' final conclusion that there should not be a deliberate policy to decrease the fraction of inspired oxygen (FiO₂) in the absence of accurate and reliable oximetry. In the developed world, accurate and reliable oximetry and blood gas results are ubiquitous in ICU settings, the context of their study. However, we have issues with the methods used to come to the conclusion that hyperoxaemia has only a weak relationship with mortality. …

Bellomo R, Bailey M, Eastwood GM, Nichol A, Pilcher D, Hart GK, Reade MC, Egi M, Cooper DJ, the Study of Oxygen in Critical Care (SOCC) Group: Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care 2011, 15: R90. 10.1186/cc10090PubMedCentralCrossRefPubMed

Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S, Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010, 303: 2165-2171. 10.1001/jama.2010.707CrossRefPubMed

de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PH, Bosman RJ, de Waal RA, Wesselink R, de Keizer NF: Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care 2008, 12: R156. 10.1186/cc7150PubMedCentralCrossRefPubMed

Kilgannon JH, Jones AE, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Shapiro NI, Trzeciak S, on behalf of the Emergency Medicine Shock Research Network (EMShockNet) Investigators: Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest. Circulation 2011, 12: 2717-2722.CrossRef

Eastwood GM, Reade MC, Peck L, Jones D, Bellomo R: Intensivists' opinion and self-reported practice of oxygen therapy. Anaesth Intensive Care 2011, 39: 122-126.PubMed

Eastwood GM, Peck L, Young H, Prowle J, Jones D, Bellomo R: Oxygen administration and monitoring for ward adult patients in a teaching hospital. Intern Med J 2010. [Epub ahead of print]

Title: How to assess the dangers of hyperoxemia: methodological issues
Authors: B Ronan O'Driscoll
Luke S Howard
Publication date: 01-06-2011
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2011
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc10272

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How to assess the dangers of hyperoxemia: methodological issues

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