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Open Access 01-12-2013 | Review

Novel aspects of Sjögren’s syndrome in 2012

Authors: Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld

Published in: BMC Medicine | Issue 1/2013

Abstract

Sjögren’s syndrome (SS) is a systemic progressive autoimmune disease characterized by a complex pathogenesis requiring a predisposing genetic background and involving immune cell activation and autoantibody production. The immune response is directed to the exocrine glands, causing the typical ‘sicca syndrome’, but major organ involvement is also often seen. The etiology of the disease is unknown. Infections could play a pivotal role: compared to normal subjects, patients with SS displayed higher titers of anti-Epstein-Barr virus (EBV) early antigens, but lower titers of other infectious agent antibodies such as rubella and cytomegalovirus (CMV) suggest that some infections may have a protective role against the development of autoimmune disease. Recent findings seem to show that low vitamin D levels in patients with SS could be associated with severe complications such as lymphoma and peripheral neuropathy. This could open new insights into the disease etiology. The current treatments for SS range from symptomatic therapies to systemic immunosuppressive drugs, especially B cell-targeted drugs in cases of organ involvement. Vitamin D supplementation may be an additional tool for optimization of SS treatment.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/93/prepub

Title: Novel aspects of Sjögren’s syndrome in 2012
Authors: Angela Tincani
Laura Andreoli
Ilaria Cavazzana
Andrea Doria
Marta Favero
Maria-Giulia Fenini
Franco Franceschini
Andrea Lojacono
Giuseppe Nascimbeni
Amerigo Santoro
Francesco Semeraro
Paola Toniati
Yehuda Shoenfeld
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/1741-7015-11-93

At a glance: The STEP trials

Springer Medicine

Novel aspects of Sjögren’s syndrome in 2012

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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