Top

Indian Journal of Otolaryngology and Head & Neck Surgery

20-04-2024 | Tracheostomy | Clinical Report

Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy

Authors: Joan Lorente-Piera, Natalia Díaz Zufiaurre, Secundino Fernández-González, Juan Alcalde

Published in: Indian Journal of Otolaryngology and Head & Neck Surgery

Abstract

Adverse effects of immunotherapeutic treatments like atezolizumab remain largely unknown due to limited experience. We present a 65-year-old man with sudden dyspnea and other symptoms, implicating immunotherapy. Prompt intervention and suspension were crucial. This study identifies a novel unreported adverse effect—bilateral vocal cord and velopalatine paralysis—associated with atezolizumab use.

Fountzilas E, Hiep Vo H, Mueller P, Kurzrock R, Tsimberidou AM (2023) Dataset of phase I and II immunotherapy clinical trials used for a meta-analysis to assess the role of biomarkers in treatment outcomes in diverse cancers. Data Brief 51:109698. https://doi.org/10.1016/j.dib.2023.109698CrossRefPubMedPubMedCentral

Willegers T, Janssen JBE, Boers-Sonderen MJ, Bekkers S (Apr 2020) Bilateral Vocal Cord Paralysis Due to an Immune-related Adverse Event of Nivolumab: A Case Report. Journal of Immunotherapy (Hagerstown, Md: 1997) 43(3):93–4. https://doi.org/10.1097/CJI.0000000000000310

Hamada S, Okamoto N, Tsukino M (2018) Bilateral vocal cord paralysis: Pembrolizumab-induced delayed-onset toxicity in a patient with lung adenocarcinoma. J Thorac Oncol. e257–9. https://doi.org/10.1016/j.jtho.2018.08.2032

Hartl DM, Ferté C, Loriot Y, Gomez Roca C, Bahleda R, Moldovan C, Mir O, Soria J-C (2010) Dysphonia induced by vascular endothelium growth factor/vascular endothelium growth factor receptor inhibitors. Invest New Drugs 28(6):884–886. https://doi.org/10.1007/s10637-009-9314-9CrossRefPubMed

-Rhee JY, Torun N, Neilan TG, Guidon AC (2022) Consider myocarditis when patients treated with immune checkpoint inhibitors present with ocular symptoms. Oncologist 27:e402–e405. https://doi.org/10.1093/oncolo/oyac033CrossRefPubMedPubMedCentral

Title: Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy
Authors: Joan Lorente-Piera
Natalia Díaz Zufiaurre
Secundino Fernández-González
Juan Alcalde
Publication date: 20-04-2024
Publisher: Springer India
Keywords: Tracheostomy
Cancer Immunotherapy
Published in: Indian Journal of Otolaryngology and Head & Neck Surgery
Print ISSN: 2231-3796
Electronic ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-024-04709-5

At a glance: The STEP trials

Springer Medicine

Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content