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Archives of Gynecology and Obstetrics

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01-01-2013 | Maternal-Fetal Medicine

Trace elements and oxidative stress in hypertensive disorders of pregnancy

Authors: Vanja Fenzl, Zlata Flegar-Meštrić, Sonja Perkov, Luka Andrišić, Franz Tatzber, Neven Žarković, Željko Duić

Published in: Archives of Gynecology and Obstetrics | Issue 1/2013

Abstract

Purpose

Due to increased metabolic requests, pregnancy can be considered as metabolic stress, especially if associated with oxidative stress triggered by disbalance of pro/antioxidants. The aim of the study was to determine serum concentrations of the trace elements iron (Fe), zinc (Zn) and copper (Cu) important in growth regulation and pro/anti-oxidant homeostasis, in relation to the total serum oxidant capacity (TOC) and total serum antioxidant capacity (TAC) in pregnant women with preeclampsia (n = 30) or with gestational hypertension (n = 30) and in healthy pregnant women (n = 37) and non-pregnant women (n = 30) as control groups expecting common differences between all pregnant women and controls and between preeclampsia and the other pregnancies indicating specific disbalance of the oxidative stress and analyzed trace elements.

Methods

Serum Fe was determined by spectrophotometric method, Cu and Zn were determined by atomic absorption spectrometry, TOC was determined by Enzymatic ANTIOX-CAP assay and TAC by Peroxide-activity assay.

Results

Serum Cu and TOC were significantly higher while Zn was lower in all pregnant groups regardless of hypertensive disorders. Serum Fe and TAC concentrations were found to be significantly higher in pregnant women with preeclampsia compared to pregnant controls.

Conclusion

Increase of TOC in all pregnant women our study points to latent oxidative stress in pregnancy. Fe might have a role in etiopathogenesis of preeclampsia while the increase of TAC in the very beginning of preeclampsia might represent a stressdefence mechanism of the body. It has still to be revealed whether significantly higher serum Fe levels are associated with preeclampsia as a cause or as a consequence of this disorder.

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Title: Trace elements and oxidative stress in hypertensive disorders of pregnancy
Authors: Vanja Fenzl
Zlata Flegar-Meštrić
Sonja Perkov
Luka Andrišić
Franz Tatzber
Neven Žarković
Željko Duić
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Archives of Gynecology and Obstetrics / Issue 1/2013
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2502-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Trace elements and oxidative stress in hypertensive disorders of pregnancy

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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