Skip to main content
Top
Published in: Health Research Policy and Systems 1/2017

Open Access 01-12-2017 | Research

Towards understanding the drivers of policy change: a case study of infection control policies for multi-drug resistant tuberculosis in South Africa

Authors: Trust Saidi, Faatiema Salie, Tania S. Douglas

Published in: Health Research Policy and Systems | Issue 1/2017

Login to get access

Abstract

Background

Explaining policy change is one of the central tasks of contemporary policy analysis. In this article, we examine the changes in infection control policies for multi-drug resistant tuberculosis (MDR-TB) in South Africa from the time the country made the transition to democracy in 1994, until 2015. We focus on MDR-TB infection control and refer to decentralised management as a form of infection control. Using Kingdon’s theoretical framework of policy streams, we explore the temporal ordering of policy framework changes. We also consider the role of research in motivating policy changes.

Methods

Policy documents addressing MDR-TB in South Africa over the period 1994 to 2014 were extracted. Literature on MDR-TB infection control in South Africa was extracted from PubMed using key search terms. The documents were analysed to identify the changes that occurred and the factors driving them.

Results

During the period under study, five different policy frameworks were implemented. The policies were meant to address the overwhelming challenge of MDR-TB in South Africa, contextualised by high prevalence of HIV infection, that threatened to undermine public health programmes and the success of antiretroviral therapy rollouts. Policy changes in MDR-TB infection control were supported by research evidence and driven by the high incidence and complexity of the disease, increasing levels of dissatisfaction among patients, challenges of physical, human and financial resources in public hospitals, and the ideologies of the political leadership. Activists and people living with HIV played an important role in highlighting the importance of MDR-TB as well as exerting pressure on policymakers, while the mass media drew public attention to infection control as both a cause of and a solution to MDR-TB.

Conclusion

The critical factors for policy change for infection control of MDR-TB in South Africa were rooted in the socioeconomic and political environment, were supported by extensive research, and can be framed using Kingdon’s policy streams approach as an interplay of the problem of the disease, political forces that prevailed and alternative proposals.
Literature
1.
go back to reference Churchyard GJ, Mametja LD, Mvusi L, Ndjeka N, Hesseling AC, Reid A, Babatunde S, Pillay Y. Tuberculosis control in South Africa: Successes, challenges and recommendations. S Afr Med J. 2014;104(3):234–48.CrossRef Churchyard GJ, Mametja LD, Mvusi L, Ndjeka N, Hesseling AC, Reid A, Babatunde S, Pillay Y. Tuberculosis control in South Africa: Successes, challenges and recommendations. S Afr Med J. 2014;104(3):234–48.CrossRef
2.
go back to reference Zignol M, Hosseini MS, Wright A, Lambregts-van Weezenbeek C, Nunn P, Watt CJ, Williams BG, Dye C. Global incidence of multidrug-resistant tuberculosis. J Infect Dis. 2006;194(4):479–85.CrossRefPubMed Zignol M, Hosseini MS, Wright A, Lambregts-van Weezenbeek C, Nunn P, Watt CJ, Williams BG, Dye C. Global incidence of multidrug-resistant tuberculosis. J Infect Dis. 2006;194(4):479–85.CrossRefPubMed
3.
go back to reference World Health Organization. 2015 Global Report on Tuberculosis. Geneva: WHO; 2015. World Health Organization. 2015 Global Report on Tuberculosis. Geneva: WHO; 2015.
4.
go back to reference World Health Organization. 2012 Global Tuberculosis Report. Geneva: WHO; 2012. World Health Organization. 2012 Global Tuberculosis Report. Geneva: WHO; 2012.
5.
go back to reference Hughes J, Osman M. Diagnosis and management of drug-resistant tuberculosis in South African adults. S Afr Med J. 2014;104(12):894.CrossRef Hughes J, Osman M. Diagnosis and management of drug-resistant tuberculosis in South African adults. S Afr Med J. 2014;104(12):894.CrossRef
7.
go back to reference Schnippel K, Long L, Meyer-Rath G, Sanne I, Rosen S, Stevens W. Impact and cost of algorithms for the diagnosis of adults with pulmonary tuberculosis in South Africa. S Afr Med J. 2013;103(7):436.CrossRefPubMed Schnippel K, Long L, Meyer-Rath G, Sanne I, Rosen S, Stevens W. Impact and cost of algorithms for the diagnosis of adults with pulmonary tuberculosis in South Africa. S Afr Med J. 2013;103(7):436.CrossRefPubMed
8.
go back to reference Andrews JR, Shah NS, Gandhi N, Moll T, Friedland G. Multidrug-resistant and extensively drug-resistant tuberculosis: implications for the HIV epidemic and antiretroviral therapy rollout in South Africa. J Infect Dis. 2007;196(Supplement 3):S482–90.CrossRefPubMed Andrews JR, Shah NS, Gandhi N, Moll T, Friedland G. Multidrug-resistant and extensively drug-resistant tuberculosis: implications for the HIV epidemic and antiretroviral therapy rollout in South Africa. J Infect Dis. 2007;196(Supplement 3):S482–90.CrossRefPubMed
9.
go back to reference Karim SS, Churchyard GJ, Karim QA, Lawn SD. HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response. Lancet. 2009;374(9693):921–33.CrossRefPubMed Karim SS, Churchyard GJ, Karim QA, Lawn SD. HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response. Lancet. 2009;374(9693):921–33.CrossRefPubMed
10.
go back to reference World Health Organization. Anti-tuberculosis drug resistance in the world, fourth global report: the WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance. Geneva: WHO; 2008. World Health Organization. Anti-tuberculosis drug resistance in the world, fourth global report: the WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance. Geneva: WHO; 2008.
11.
go back to reference Umanah T, Ncayiyana J, Padanilam X, Nyasulu PS. Treatment outcomes in multidrug resistant tuberculosis-human immunodeficiency virus co-infected patients on anti-retroviral therapy at Sizwe Tropical Disease Hospital Johannesburg, South Africa. BMC Infect Dis. 2015;15:478.CrossRefPubMedPubMedCentral Umanah T, Ncayiyana J, Padanilam X, Nyasulu PS. Treatment outcomes in multidrug resistant tuberculosis-human immunodeficiency virus co-infected patients on anti-retroviral therapy at Sizwe Tropical Disease Hospital Johannesburg, South Africa. BMC Infect Dis. 2015;15:478.CrossRefPubMedPubMedCentral
12.
go back to reference Farley JE, Ram M, Pan W, Waldman S, Cassell GH, Chaisson RE, Weyer K, Lancaster J, Van der Walt M. Outcomes of multi-drug resistant tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence. PLoS One. 2011;6(7):e20436.CrossRefPubMedPubMedCentral Farley JE, Ram M, Pan W, Waldman S, Cassell GH, Chaisson RE, Weyer K, Lancaster J, Van der Walt M. Outcomes of multi-drug resistant tuberculosis (MDR-TB) among a cohort of South African patients with high HIV prevalence. PLoS One. 2011;6(7):e20436.CrossRefPubMedPubMedCentral
13.
go back to reference Farley JE, Tudor C, Mphahlele M, Franz K, Perrin NA, Dorman S, Van der Walt M. A national infection control evaluation of drug-resistant tuberculosis hospitals in South Africa. Int J Tuberc Lung Dis. 2012;16(1):82–9.CrossRefPubMed Farley JE, Tudor C, Mphahlele M, Franz K, Perrin NA, Dorman S, Van der Walt M. A national infection control evaluation of drug-resistant tuberculosis hospitals in South Africa. Int J Tuberc Lung Dis. 2012;16(1):82–9.CrossRefPubMed
14.
go back to reference World Health Organization. Multidrug and extensively drug-resistant TB. Geneva: WHO; 2010. World Health Organization. Multidrug and extensively drug-resistant TB. Geneva: WHO; 2010.
15.
go back to reference Calver AD, Murray M, Strauss OJ, Streicher EM, Hanekom M, Liversage T, Masibi M, Van Helden PD, Warren RM, Victor TC. Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa. Emerg Infect Dis. 2010;16(2):264–71.CrossRefPubMedPubMedCentral Calver AD, Murray M, Strauss OJ, Streicher EM, Hanekom M, Liversage T, Masibi M, Van Helden PD, Warren RM, Victor TC. Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa. Emerg Infect Dis. 2010;16(2):264–71.CrossRefPubMedPubMedCentral
16.
go back to reference Falzon D, Mirzayev F, Wares F, Baena IG, Zignol M, Linh N, Weyer K, Jaramillo E, Floyd K, Raviglione M. Multidrug-resistant tuberculosis around the world: what progress has been made? Eur Respir J. 2015;45(1):150–60.CrossRefPubMed Falzon D, Mirzayev F, Wares F, Baena IG, Zignol M, Linh N, Weyer K, Jaramillo E, Floyd K, Raviglione M. Multidrug-resistant tuberculosis around the world: what progress has been made? Eur Respir J. 2015;45(1):150–60.CrossRefPubMed
17.
go back to reference Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006;368(9547):1575–80.CrossRefPubMed Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, Zeller K, Andrews J, Friedland G. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet. 2006;368(9547):1575–80.CrossRefPubMed
18.
go back to reference Nathanson E, Nunn P, Uplekar M, Floyd K, Jaramillo E, Lönnroth K, Weil D, Raviglione M. MDR tuberculosis—critical steps for prevention and control. N Engl J Med. 2010;363(11):1050–8.CrossRefPubMed Nathanson E, Nunn P, Uplekar M, Floyd K, Jaramillo E, Lönnroth K, Weil D, Raviglione M. MDR tuberculosis—critical steps for prevention and control. N Engl J Med. 2010;363(11):1050–8.CrossRefPubMed
19.
go back to reference World Health Organization. Global Tuberculosis Control. Geneva: WHO; 2009. World Health Organization. Global Tuberculosis Control. Geneva: WHO; 2009.
20.
go back to reference Cain KP, Nelson LJ, Cegielski JP. Global policies and practices for managing persons exposed to multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2010;14(3):269–74.PubMed Cain KP, Nelson LJ, Cegielski JP. Global policies and practices for managing persons exposed to multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2010;14(3):269–74.PubMed
21.
go back to reference Gandhi NR, Nunn P, Dheda K, Schaaf HS, Zignol M, Van Soolingen D, Jensen P, Bayona J. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. Lancet. 2010;375(9728):1830–43.CrossRefPubMed Gandhi NR, Nunn P, Dheda K, Schaaf HS, Zignol M, Van Soolingen D, Jensen P, Bayona J. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. Lancet. 2010;375(9728):1830–43.CrossRefPubMed
22.
go back to reference Tudor C, Van der Walt M, Margot B, Dorman SE, Pan WK, Yenokyan G, Farley JE. Tuberculosis among health care workers in KwaZulu-Natal, South Africa: a retrospective cohort analysis. BMC Public Health. 2014;14:891.CrossRefPubMedPubMedCentral Tudor C, Van der Walt M, Margot B, Dorman SE, Pan WK, Yenokyan G, Farley JE. Tuberculosis among health care workers in KwaZulu-Natal, South Africa: a retrospective cohort analysis. BMC Public Health. 2014;14:891.CrossRefPubMedPubMedCentral
23.
go back to reference Cox HS, McDermid C, Azevedo V, Muller O, Coetzee D, Simpson J, Barnard M, Coetzee G, van Cutsem G, Goemaere E. Epidemic levels of drug resistant tuberculosis (MDR and XDR-TB) in a high HIV prevalence setting in Khayelitsha, South Africa. PLoS One. 2010;5(11):e13901.CrossRefPubMedPubMedCentral Cox HS, McDermid C, Azevedo V, Muller O, Coetzee D, Simpson J, Barnard M, Coetzee G, van Cutsem G, Goemaere E. Epidemic levels of drug resistant tuberculosis (MDR and XDR-TB) in a high HIV prevalence setting in Khayelitsha, South Africa. PLoS One. 2010;5(11):e13901.CrossRefPubMedPubMedCentral
24.
go back to reference Lönnroth K, Castro KG, Chakaya JM, Chauhan LS, Floyd K, Glaziou P, Raviglione MC. Tuberculosis control and elimination 2010–50: cure, care, and social development. Lancet. 2010;375(9728):1814–29.CrossRefPubMed Lönnroth K, Castro KG, Chakaya JM, Chauhan LS, Floyd K, Glaziou P, Raviglione MC. Tuberculosis control and elimination 2010–50: cure, care, and social development. Lancet. 2010;375(9728):1814–29.CrossRefPubMed
25.
go back to reference World Health Organization. WHO Policy on TB Infection Control in Health-care Facilities, Congregate Settings and Households. Geneva: WHO; 2009. World Health Organization. WHO Policy on TB Infection Control in Health-care Facilities, Congregate Settings and Households. Geneva: WHO; 2009.
26.
go back to reference Kingdon JW. Agendas, Alternatives, and Public Policies. Boston: Little Brown; 1984. Kingdon JW. Agendas, Alternatives, and Public Policies. Boston: Little Brown; 1984.
27.
go back to reference Sabatier PA, Jenkins-Smith HC. Policy Change and Learning: An Advocacy Coalition Approach. Colorado: Westview Press; 1993. Sabatier PA, Jenkins-Smith HC. Policy Change and Learning: An Advocacy Coalition Approach. Colorado: Westview Press; 1993.
28.
go back to reference Kingdon JW. How do Issues Get on Public Policy Agendas: Sociology and the Public Policy Agenda. London: Sage Publishers; 1993.CrossRef Kingdon JW. How do Issues Get on Public Policy Agendas: Sociology and the Public Policy Agenda. London: Sage Publishers; 1993.CrossRef
29.
go back to reference Department of Health. The Management of Multi-drug Resistant Tuberculosis in South Africa. Pretoria: DoH; 1999. Department of Health. The Management of Multi-drug Resistant Tuberculosis in South Africa. Pretoria: DoH; 1999.
30.
go back to reference Department of Health. South African National Tuberculosis Control Programme Practical Guidelines in 2004. Pretoria: DoH; 2004. Department of Health. South African National Tuberculosis Control Programme Practical Guidelines in 2004. Pretoria: DoH; 2004.
32.
go back to reference Department of Health. Management of Drug-Resistant Tuberculosis. Pretoria: DoH; 2010. Department of Health. Management of Drug-Resistant Tuberculosis. Pretoria: DoH; 2010.
33.
go back to reference Department of Health. Multi-Drug Resistant Tuberculosis: A Policy Framework on Decentralised and Deinstitutionalised Management for South Africa. Pretoria: DoH; 2011. Department of Health. Multi-Drug Resistant Tuberculosis: A Policy Framework on Decentralised and Deinstitutionalised Management for South Africa. Pretoria: DoH; 2011.
34.
go back to reference Parsons S, Abbott G, de Jager P, Conradie D, Bole S. Researched Solutions for Long-term Accommodation Units for Drug-resistant Tuberculosis Patients in South Africa. Proceedings of the Science Real and Relevant Conference. Pretoria: CSIR; 2010. Parsons S, Abbott G, de Jager P, Conradie D, Bole S. Researched Solutions for Long-term Accommodation Units for Drug-resistant Tuberculosis Patients in South Africa. Proceedings of the Science Real and Relevant Conference. Pretoria: CSIR; 2010.
35.
go back to reference World Health Organization. Global Tuberculosis Control: Surveillance, Planning, Financing. Geneva: WHO; 2006. World Health Organization. Global Tuberculosis Control: Surveillance, Planning, Financing. Geneva: WHO; 2006.
36.
go back to reference World Health Organization. Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis. Geneva: WHO; 2008. World Health Organization. Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis. Geneva: WHO; 2008.
37.
go back to reference Narasimooloo R, Ross A. Delay in commencing treatment for MDR-TB at a specialised TB treatment centre in KwaZulu-Natal. S Afr Med J. 2012;102(6):360–3.CrossRefPubMed Narasimooloo R, Ross A. Delay in commencing treatment for MDR-TB at a specialised TB treatment centre in KwaZulu-Natal. S Afr Med J. 2012;102(6):360–3.CrossRefPubMed
38.
go back to reference Department of Health. Management of Drug-Resistant Tuberculosis. Pretoria: DoH; 2013. Department of Health. Management of Drug-Resistant Tuberculosis. Pretoria: DoH; 2013.
39.
go back to reference Wallengren K, Scano F, Nunn P, Margot B, Buthelezi SS, Williams B, Pym A, Samuel EY, Mirzayev F, Nkhoma W, Mvusi L. Drug-resistant tuberculosis, KwaZulu-Natal, South Africa, 2001–2007. Emerg Infect Dis. 2011;17(10):1913–6.CrossRefPubMedPubMedCentral Wallengren K, Scano F, Nunn P, Margot B, Buthelezi SS, Williams B, Pym A, Samuel EY, Mirzayev F, Nkhoma W, Mvusi L. Drug-resistant tuberculosis, KwaZulu-Natal, South Africa, 2001–2007. Emerg Infect Dis. 2011;17(10):1913–6.CrossRefPubMedPubMedCentral
40.
go back to reference Engelbrecht M, van Rensburg AJ, Kigozi G, van Rensburg HD. Factors associated with good TB infection control practices among primary healthcare workers in the Free State Province, South Africa. BMC Infect Dis. 2016;16:633.CrossRefPubMedPubMedCentral Engelbrecht M, van Rensburg AJ, Kigozi G, van Rensburg HD. Factors associated with good TB infection control practices among primary healthcare workers in the Free State Province, South Africa. BMC Infect Dis. 2016;16:633.CrossRefPubMedPubMedCentral
41.
go back to reference Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH. Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. J Hosp Infect. 2011;79(4):333–8.CrossRefPubMed Kanjee Z, Catterick K, Moll AP, Amico KR, Friedland GH. Tuberculosis infection control in rural South Africa: survey of knowledge, attitude and practice in hospital staff. J Hosp Infect. 2011;79(4):333–8.CrossRefPubMed
42.
go back to reference Bamford CM, Taljaard JJ. Potential for nosocomial transmission of multidrug-resistant (MDR) tuberculosis in a South African tertiary hospital. S Afr Med J. 2010;100(7):438–41.CrossRefPubMed Bamford CM, Taljaard JJ. Potential for nosocomial transmission of multidrug-resistant (MDR) tuberculosis in a South African tertiary hospital. S Afr Med J. 2010;100(7):438–41.CrossRefPubMed
43.
go back to reference Gandhi NR, Weissman D, Moodley P, Ramathal M, Elson I, Kreiswirth BN, Mathema B, Shashkina E, Rothenberg R, Moll AP, Friedland G. Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa. J Infect Dis. 2013;207(1):9–17.CrossRefPubMed Gandhi NR, Weissman D, Moodley P, Ramathal M, Elson I, Kreiswirth BN, Mathema B, Shashkina E, Rothenberg R, Moll AP, Friedland G. Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa. J Infect Dis. 2013;207(1):9–17.CrossRefPubMed
44.
go back to reference Basu S, Andrews JR, Poolman EM, Gandhi NR, Shah NS, Moll A, Moodley P, Galvani AP, Friedland GH. Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study. Lancet. 2007;370(9597):1500–7.CrossRefPubMedPubMedCentral Basu S, Andrews JR, Poolman EM, Gandhi NR, Shah NS, Moll A, Moodley P, Galvani AP, Friedland GH. Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study. Lancet. 2007;370(9597):1500–7.CrossRefPubMedPubMedCentral
45.
go back to reference Andrews JR, Gandhi NR, Moodley P, Shah NS, Bohlken L, Moll AP, Pillay M, Friedland G, Sturm AW. Exogenous reinfection as a cause of multidrug-resistant and extensively drug-resistant tuberculosis in rural South Africa. J Infect Dis. 2008;198(11):1582–9.CrossRefPubMed Andrews JR, Gandhi NR, Moodley P, Shah NS, Bohlken L, Moll AP, Pillay M, Friedland G, Sturm AW. Exogenous reinfection as a cause of multidrug-resistant and extensively drug-resistant tuberculosis in rural South Africa. J Infect Dis. 2008;198(11):1582–9.CrossRefPubMed
46.
go back to reference Dheda K, Shean K, Zumla A, Badri M, Streicher EM, Page-Shipp L, Willcox P, John MA, Reubenson G, Govindasamy D, Wong M. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet. 2010;375(9728):1798–807.CrossRefPubMed Dheda K, Shean K, Zumla A, Badri M, Streicher EM, Page-Shipp L, Willcox P, John MA, Reubenson G, Govindasamy D, Wong M. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet. 2010;375(9728):1798–807.CrossRefPubMed
47.
go back to reference Heller T, Lessells RJ, Wallrauch CG, Bärnighausen T, Cooke GS, Mhlongo L, Master I, Newell ML. Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2010;14(4):420–6.PubMed Heller T, Lessells RJ, Wallrauch CG, Bärnighausen T, Cooke GS, Mhlongo L, Master I, Newell ML. Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2010;14(4):420–6.PubMed
48.
go back to reference Brust JC, Shah NS, Scott M, Chaiyachati K, Lygizos M, van der Merwe TL, Bamber S, Radebe Z, Loveday M, Moll AP, Margot B. Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care [Perspectives]. Int J Tuberc Lung Dis. 2012;16(8):998–1004.CrossRefPubMedPubMedCentral Brust JC, Shah NS, Scott M, Chaiyachati K, Lygizos M, van der Merwe TL, Bamber S, Radebe Z, Loveday M, Moll AP, Margot B. Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care [Perspectives]. Int J Tuberc Lung Dis. 2012;16(8):998–1004.CrossRefPubMedPubMedCentral
51.
go back to reference Parsons S, Abbott G, de Jager P, Conradie D, Bole S. Researched solutions for long-term accommodation units for drug-resistant tuberculosis patients in South Africa. CSIR 3rd Biennial Conference 2010. Science Real and Relevant, CSIR International Convention Centre, Pertoria, 30 August – 01 September 2010. Parsons S, Abbott G, de Jager P, Conradie D, Bole S. Researched solutions for long-term accommodation units for drug-resistant tuberculosis patients in South Africa. CSIR 3rd Biennial Conference 2010. Science Real and Relevant, CSIR International Convention Centre, Pertoria, 30 August – 01 September 2010.
52.
go back to reference IUSS. TB Services-IUSS Health Facility Guides. Pretoria: DoH; 2014. IUSS. TB Services-IUSS Health Facility Guides. Pretoria: DoH; 2014.
53.
go back to reference Department of Health. Tuberculosis Strategic Plan for South Africa, 2007-2011. Pretoria: DoH; 2007. Department of Health. Tuberculosis Strategic Plan for South Africa, 2007-2011. Pretoria: DoH; 2007.
55.
go back to reference Tudor C, Mphahlele M, Van der Walt M, Farley JE. Health care workers' fears associated with working in multidrug-and or extensively-resistant tuberculosis wards in South Africa. Int J Tuberc Lung Dis. 2013;17(10):22–9.CrossRefPubMed Tudor C, Mphahlele M, Van der Walt M, Farley JE. Health care workers' fears associated with working in multidrug-and or extensively-resistant tuberculosis wards in South Africa. Int J Tuberc Lung Dis. 2013;17(10):22–9.CrossRefPubMed
56.
go back to reference Naidoo A, Naidoo S, Gathiram P, Lalloo U. Tuberculosis in medical doctors-a study of personal experiences and attitudes. S Afr Med J. 2013;103(3):176–80.CrossRefPubMed Naidoo A, Naidoo S, Gathiram P, Lalloo U. Tuberculosis in medical doctors-a study of personal experiences and attitudes. S Afr Med J. 2013;103(3):176–80.CrossRefPubMed
57.
go back to reference Daku M, Gibbs A, Heymann J. Representations of MDR and XDR-TB in South African newspapers. Soc Sci Med. 2012;75(2):410–8.CrossRefPubMed Daku M, Gibbs A, Heymann J. Representations of MDR and XDR-TB in South African newspapers. Soc Sci Med. 2012;75(2):410–8.CrossRefPubMed
58.
go back to reference Lalloo UG, Pillay S. Managing tuberculosis and HIV in sub-Sahara Africa. Curr HIV/AIDS Rep. 2008;5(3):132–9.CrossRefPubMed Lalloo UG, Pillay S. Managing tuberculosis and HIV in sub-Sahara Africa. Curr HIV/AIDS Rep. 2008;5(3):132–9.CrossRefPubMed
59.
go back to reference Owen CP. A Policy for the Development of a District Health System for South Africa National Health Systems. Pretoria: DoH; 1996. Owen CP. A Policy for the Development of a District Health System for South Africa National Health Systems. Pretoria: DoH; 1996.
61.
go back to reference Dorrington R, Bourne D, Bradshaw D, Laubscher R, Timæus IM. The Impact of HIV/AIDS on Adult Mortality in South Africa. Cape Town: Medical Research Council; 2001. Dorrington R, Bourne D, Bradshaw D, Laubscher R, Timæus IM. The Impact of HIV/AIDS on Adult Mortality in South Africa. Cape Town: Medical Research Council; 2001.
62.
go back to reference Johnson K. The politics of AIDS policy development and implementation in postapartheid South Africa. Afr Today. 2004;51(2):107–28.CrossRef Johnson K. The politics of AIDS policy development and implementation in postapartheid South Africa. Afr Today. 2004;51(2):107–28.CrossRef
63.
go back to reference Schneider H, Stein J. Implementing AIDS policy in post-apartheid South Africa. Soc Sci Med. 2001;52(5):723–31.CrossRefPubMed Schneider H, Stein J. Implementing AIDS policy in post-apartheid South Africa. Soc Sci Med. 2001;52(5):723–31.CrossRefPubMed
64.
go back to reference Bekker LG, Venter F, Cohen K, Goemare E, Van Cutsem G, Boulle A, Wood R. Provision of antiretroviral therapy in South Africa: the nuts and bolts. Antivir Ther. 2014;19 Suppl 3:105–16.CrossRefPubMed Bekker LG, Venter F, Cohen K, Goemare E, Van Cutsem G, Boulle A, Wood R. Provision of antiretroviral therapy in South Africa: the nuts and bolts. Antivir Ther. 2014;19 Suppl 3:105–16.CrossRefPubMed
65.
go back to reference London L, Cox H, Coomans F. Multidrug-resistant TB: implementing the right to health through the right to enjoy the benefits of scientific progress. Health Hum Rights J. 2016;18(1):25–41. London L, Cox H, Coomans F. Multidrug-resistant TB: implementing the right to health through the right to enjoy the benefits of scientific progress. Health Hum Rights J. 2016;18(1):25–41.
66.
go back to reference IRIN. South Africa: Prison-like Hospitals for Drug-resistant TB Patients, Humanitarian News and Analysis. Johannesburg: UN Office for the Coordination of Humanitarian Affairs; 2014. IRIN. South Africa: Prison-like Hospitals for Drug-resistant TB Patients, Humanitarian News and Analysis. Johannesburg: UN Office for the Coordination of Humanitarian Affairs; 2014.
67.
go back to reference AIDS Consortium. Information Pack: TB/HIV Co-infection. Johannesburg: The Aids Consortium Company; 2009. AIDS Consortium. Information Pack: TB/HIV Co-infection. Johannesburg: The Aids Consortium Company; 2009.
68.
go back to reference Cox H, Hughes J, Daniels J, Azevedo V, McDermid C, Poolman M, Boulle A, Goemaere E, Van Cutsem G. Community-based treatment of drug-resistant tuberculosis in Khayelitsha, South Africa. Int J Tuberc Lung Dis. 2014;18(4):441–8.CrossRefPubMed Cox H, Hughes J, Daniels J, Azevedo V, McDermid C, Poolman M, Boulle A, Goemaere E, Van Cutsem G. Community-based treatment of drug-resistant tuberculosis in Khayelitsha, South Africa. Int J Tuberc Lung Dis. 2014;18(4):441–8.CrossRefPubMed
72.
go back to reference Yagui M, Perales MT, Asencios L, Vergara L, Suarez C, Yale G, Salazar C, Saavedra M, Shin S, Ferrousier O, Cegielski P. Timely diagnosis of MDR-TB under program conditions: is rapid drug susceptibility testing sufficient? Int J Tuberc Lung Dis. 2006;10(8):838–43.PubMed Yagui M, Perales MT, Asencios L, Vergara L, Suarez C, Yale G, Salazar C, Saavedra M, Shin S, Ferrousier O, Cegielski P. Timely diagnosis of MDR-TB under program conditions: is rapid drug susceptibility testing sufficient? Int J Tuberc Lung Dis. 2006;10(8):838–43.PubMed
73.
go back to reference Padayatchi N, Friedland G. Decentralised management of drug-resistant tuberculosis (MDR-and XDR-TB) in South Africa: an alternative model of care [Short communication]. Int J Tuberc Lung Dis. 2008;12(8):978–80.PubMed Padayatchi N, Friedland G. Decentralised management of drug-resistant tuberculosis (MDR-and XDR-TB) in South Africa: an alternative model of care [Short communication]. Int J Tuberc Lung Dis. 2008;12(8):978–80.PubMed
74.
go back to reference Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: amulticentre implementation study. Lancet. 2011;377:1495–505.CrossRefPubMedPubMedCentral Boehme CC, Nicol MP, Nabeta P, Michael JS, Gotuzzo E, Tahirli R, Gler MT, Blakemore R, Worodria W, Gray C, Huang L. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: amulticentre implementation study. Lancet. 2011;377:1495–505.CrossRefPubMedPubMedCentral
75.
go back to reference Scano F, Vitoria M, Burman W, Harries AD, Gilks CF, Havlir D. Management of HIV-infected patients with MDR-and XDR-TB in resource-limited settings [Unresolved issues]. Int J Tuberc Lung Dis. 2008;12(12):1370–5.PubMed Scano F, Vitoria M, Burman W, Harries AD, Gilks CF, Havlir D. Management of HIV-infected patients with MDR-and XDR-TB in resource-limited settings [Unresolved issues]. Int J Tuberc Lung Dis. 2008;12(12):1370–5.PubMed
76.
go back to reference van Cutsem G, Isaakidis P, Farley J, Nardell E, Volchenkov G, Cox H. Infection control for drug-resistant tuberculosis: early diagnosis and treatment is the key. Clin Infect Dis. 2016;62 suppl 3:S238–43.CrossRefPubMedPubMedCentral van Cutsem G, Isaakidis P, Farley J, Nardell E, Volchenkov G, Cox H. Infection control for drug-resistant tuberculosis: early diagnosis and treatment is the key. Clin Infect Dis. 2016;62 suppl 3:S238–43.CrossRefPubMedPubMedCentral
77.
go back to reference Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, Masotla T, Lubbe W, Pagano M, First M, Jensen PA, van der Walt M. Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012;185(10):1104–9.CrossRefPubMedPubMedCentral Dharmadhikari AS, Mphahlele M, Stoltz A, Venter K, Mathebula R, Masotla T, Lubbe W, Pagano M, First M, Jensen PA, van der Walt M. Surgical face masks worn by patients with multidrug-resistant tuberculosis: impact on infectivity of air on a hospital ward. Am J Respir Crit Care Med. 2012;185(10):1104–9.CrossRefPubMedPubMedCentral
78.
go back to reference Cox H, Escombe R, McDermid C, Mtshemla Y, Spelman T, Azevedo V, London L. Wind-driven roof turbines: a novel way to improve ventilation for TB infection control in health facilities. PLoS One. 2012;7(1):e29589.CrossRefPubMedPubMedCentral Cox H, Escombe R, McDermid C, Mtshemla Y, Spelman T, Azevedo V, London L. Wind-driven roof turbines: a novel way to improve ventilation for TB infection control in health facilities. PLoS One. 2012;7(1):e29589.CrossRefPubMedPubMedCentral
Metadata
Title
Towards understanding the drivers of policy change: a case study of infection control policies for multi-drug resistant tuberculosis in South Africa
Authors
Trust Saidi
Faatiema Salie
Tania S. Douglas
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Health Research Policy and Systems / Issue 1/2017
Electronic ISSN: 1478-4505
DOI
https://doi.org/10.1186/s12961-017-0203-y

Other articles of this Issue 1/2017

Health Research Policy and Systems 1/2017 Go to the issue