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Netherlands Heart Journal
Published in: Netherlands Heart Journal 11/2018

Open Access 01-11-2018 | Editor’s Comment

Towards evidence-based management of patients treated with cardiotoxic chemotherapy: A collaborative effort of cardiologists and oncologists

Authors: J. M. Leerink, Y. M. Pinto

Published in: Netherlands Heart Journal | Issue 11/2018

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Excerpt

Chemotherapeutic agents have contributed importantly to the increased survival of patients with cancer. However, with greater survival, their cardiotoxic side effects emerge more often as a source of great concern [1]. Already in the 1970s during the first trials with anthracyclines, a potent antineoplastic agent, patients died due to congestive heart failure [2‐4] which was, with the current knowledge, likely to be caused by the toxic effects of anthracyclines on cardiomyocytes which led to a decreased left ventricular function. However, almost 50 years after their first routine use, the exact mechanism by which anthracyclines induce cardiotoxicity remains elusive [5]. …
Literature
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Bonadonna G, Monfardini S, De Lena M, et al. Phase I and preliminary phase II evaluation of adriamycin (NSC 123127). Cancer Res. 1970;30:2572–82.PubMed
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Lefrak EA, Pitha J, Rosenheim S, et al. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer. 1973;32:302–14.CrossRef
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Middleman E, Luce J, Frei E, et al. Clinical trials with adriamycin. Cancer. 1971;28:844–50.CrossRef
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Henriksen PA. Anthracycline cardiotoxicity: an update on mechanisms, monitoring and prevention. Heart. 2018;104:971–7.CrossRef
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Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments. Nat Rev Cardiol. 2015;12:547–58.CrossRef
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Zamorano JL, Lancellotti P, Rodriguez Munoz D, et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:2768–801.CrossRef
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Herrmann J, Lerman A, Sandhu NP, et al. Evaluation and management of patients with heart disease and cancer: cardio-oncology. Mayo Clin Proc. 2014;89:1287–306.CrossRef
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Cardinale D, Colombo A, Bacchiani G, et al. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015;131:1981–8.CrossRef
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van der Pal HJ, van Dalen EC, van Delden E, et al. High risk of symptomatic cardiac events in childhood cancer survivors. J Clin Oncol. 2012;30:1429–37.CrossRef
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Sieswerda E, Postma A, van Dalen EC, et al. The Dutch Childhood Oncology Group guideline for follow-up of asymptomatic cardiac dysfunction in childhood cancer survivors. Ann Oncol. 2012;23:2191–8.CrossRef
Metadata
Title
Towards evidence-based management of patients treated with cardiotoxic chemotherapy: A collaborative effort of cardiologists and oncologists
Authors
J. M. Leerink
Y. M. Pinto
Publication date
01-11-2018
Publisher
Bohn Stafleu van Loghum
Published in
Netherlands Heart Journal / Issue 11/2018
Print ISSN: 1568-5888
Electronic ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-018-1163-8

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