01-11-2018 | Original Article
Towards an individual screening strategy for first-degree relatives of celiac patients
Published in: European Journal of Pediatrics | Issue 11/2018
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What is Known:
• Celiac disease is more prevalent in first-degree relatives of celiac patients (risk 3–12%).
• HLA-DQ2 homozygous sisters/daughters are at highest risk (25%).
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What is New:
• If younger than 10 years of age, repeated testing is necessary in HLA-DQ2/DQ8-positive first-degree relatives when celiac disease is diagnosed in a family.
• One-time celiac-specific antibody testing alone could be sufficient to rule out the disease in adolescent siblings and parents of newly diagnosed celiac patients.
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