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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 12/2005

01-12-2005 | Original Contribution

Total Mesorectal Excision for Rectal Cancer: Difference in Outcome for Low and High Rectal Cancer

Authors: Arne E. Faerden, M.D., Nazir Naimy, M.D., Pål Wiik, M.D., Ph.D., Ola Reiertsen, M.D., Ph.D., Seyoum Weyessa, M.D., Sigurd Trønnes, M.D., Solveig Norheim Andersen, M.D., Ph.D., Arne Bakka, M.D., Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 12/2005

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PURPOSE

This prospective study was designed to assess the outcome through the first five years after the introduction of total mesorectal excision in 1993 in a Norwegian central hospital, with special regard to the difference between low (≤6 cm from anal verge) and high (>6 cm) rectal cancers.

METHODS

A total of 140 patients (81 males; median age, 64 (range, 29–87) years) underwent surgery for rectal cancer under curative intention.

RESULTS

Local recurrence rates were 8 of 44 (18 percent) for the low cancers and 5 of 96 (5 percent) for the high, a statistically significant difference (P = 0.0014). Corresponding numbers when the R1 resections are excluded were 5 of 36 (13 percent) for the low and 4 of 92 (4 percent) for the high cancers (P = 0.002). The five-year survival after R0 resections of cancers <6 cm was significantly reduced compared with those >6 cm. The five-year overall survival for the whole material was 72 percent.

CONCLUSIONS

Surgery alone for rectal cancer can achieve overall good results, with five-year overall survival of 72 percent. The prognosis of the cancers of the lower rectum seems to be inherently different from the tumors of the higher level, both concerning local recurrence and five-year survival, suggesting different biologic behavior of the two cancers.
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Metadata
Title
Total Mesorectal Excision for Rectal Cancer: Difference in Outcome for Low and High Rectal Cancer
Authors
Arne E. Faerden, M.D.
Nazir Naimy, M.D.
Pål Wiik, M.D., Ph.D.
Ola Reiertsen, M.D., Ph.D.
Seyoum Weyessa, M.D.
Sigurd Trønnes, M.D.
Solveig Norheim Andersen, M.D., Ph.D.
Arne Bakka, M.D., Ph.D.
Publication date
01-12-2005
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 12/2005
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-005-0191-9

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