Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 3/2012

01-03-2012 | Case Report

Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect

Authors: George I. Agorogiannis, Vassilia-Ismini Alexaki, Ourania Castana, George D. Kymionis

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2012

Login to get access

Excerpt

Different causes of corneal persistent epithelial defects (PED) have been described including dry eye, corneal epithelial stem cell deficiency, diabetes mellitus, and neurotrophic keratopathy (after herpetic keratitis or corneal surgery). Corneal PEDs could lead to a cascade of events throughout the cornea, resulting in stromal degradation, thinning and in advanced cases, corneal perforation. …
Literature
1.
go back to reference Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353PubMed Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353PubMed
2.
go back to reference Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570–579PubMedCrossRef Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570–579PubMedCrossRef
3.
go back to reference Bunnell BA, Flaat M, Gaqliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120PubMedCrossRef Bunnell BA, Flaat M, Gaqliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120PubMedCrossRef
4.
go back to reference Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E (2009) Adipocytes as immune cells: differential expression of TWEAK, BAFF and APRIL and their receptors (Fn14, BAFF-R, TACI and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 183:5948–5956PubMedCrossRef Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E (2009) Adipocytes as immune cells: differential expression of TWEAK, BAFF and APRIL and their receptors (Fn14, BAFF-R, TACI and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 183:5948–5956PubMedCrossRef
5.
go back to reference Daher SR, Johnstone BH, Phinney DG, March KL (2008) Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 26:2664–2665PubMedCrossRef Daher SR, Johnstone BH, Phinney DG, March KL (2008) Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 26:2664–2665PubMedCrossRef
6.
go back to reference Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736PubMedCrossRef Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736PubMedCrossRef
7.
go back to reference Phinney DG, Prockop DJ (2007) Mesenchymal stem/multi-potent stromal cells (MSCs): the state of transdifferentiation and modes of tissue repair — current views. Stem Cells 25:2896–2902PubMedCrossRef Phinney DG, Prockop DJ (2007) Mesenchymal stem/multi-potent stromal cells (MSCs): the state of transdifferentiation and modes of tissue repair — current views. Stem Cells 25:2896–2902PubMedCrossRef
8.
go back to reference Körbling M, Estrov Z (2003) Adult stem cells for tissue repair — a new therapeutic concept? N Engl J Med 349:570–582PubMedCrossRef Körbling M, Estrov Z (2003) Adult stem cells for tissue repair — a new therapeutic concept? N Engl J Med 349:570–582PubMedCrossRef
9.
go back to reference Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385–386PubMedCrossRef Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385–386PubMedCrossRef
10.
go back to reference Meirelles Lda S, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419–427PubMedCrossRef Meirelles Lda S, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419–427PubMedCrossRef
Metadata
Title
Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect
Authors
George I. Agorogiannis
Vassilia-Ismini Alexaki
Ourania Castana
George D. Kymionis
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2012
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-011-1841-3

Other articles of this Issue 3/2012

Graefe's Archive for Clinical and Experimental Ophthalmology 3/2012 Go to the issue