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Whipple's Disease 

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  1. Open Access 01-12-2024 | Whipple's Disease | OriginalPaper

    Immune recovery uveitis in Whipple’s disease: an unusual ocular presentation

    Whipple's disease (WD) is a rare systemic infection caused by the gram-positive actinobacterium Tropheryma whipplei (TW), which typically affects middle-aged white men [ 1 ]. Manifestations of WD include weight loss, diarrhea, abdominal pain …

  2. 27-09-2023 | Whipple's Disease | Online First

    Mycobacterium avium complex small bowel disease mimicking Whipple’s disease

  3. 06-05-2022 | Joint Pain | OriginalPaper

    Whipple’s disease with normal duodenal histology diagnosed by ileal biopsy using balloon endoscopy

    A 34 year-old previously healthy Japanese woman presented with a 4 year history of migratory arthralgia, chronic diarrhea, mild fever, and 10 kg weight loss. She was initially misdiagnosed with seronegative arthritis, followed by eosinophilic …

  4. Open Access 01-12-2023 | Doxycycline | OriginalPaper

    Whipple’s disease presenting as weight gain and constipation in a Chinese woman

    Whipple’s disease is a chronic infection due to Tropheryma whipplei , first described by George H. Whipple in 1907 [ 1 ]. It is mostly reported in the Caucasian population, but only a few cases have been reported in the Asian population [ 2 , 3 ].

  5. Open Access 01-12-2021 | Tropheryma Whipplei | OriginalPaper

    Whipple's disease: the great masquerader—a high level of suspicion is the key to diagnosis

    Whipple’s disease (WD) is an infectious disease caused by the gram-positive bacterium Tropheryma whipplei . The first case was presented in 1907 by the pathologist George Hoyt Whipple [ 1 ] who named the disease lipodystrophy based on storage of …

  6. Open Access 01-12-2023 | Whipple's Disease | OriginalPaper

    An unusual presentation of a rare disease: acute upper limb ischemia as the presenting symptom of Whipple’s Endocarditis, a case report

    Whipple’s disease is a rare disease caused by Tropheryma whipplei , a gram-positive bacillus. The spectrum of clinical findings due to T. whipplei infection is wide [ 1 , 2 ]. Classic Whipple’s disease involves multiple organ systems and causes a …

  7. 01-12-2020 | Stroke

    Thrombocytopenia and endocarditis in a patient with Whipple’s disease: case report

    Whipple’s disease (WD) is a rare multisystem infectious disorder characterized by joint pain, diarrhea, abdominal pain, failure to thrive and progressive wasting. It is caused by the actinomycete Tropheryma whipplei which is ubiquitous in the …

  8. Open Access 01-12-2019 | Tropheryma Whipplei | OriginalPaper

    Another Whipple’s triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective

    Whipple’s disease is a rare disease that classically afflicts middle-aged white men with an annual incidence of > 1/1,000,000. The prototypical clinical presentation of Whipple’s includes arthralgia (87%), diarrhea (81%), weight loss (93%) …

  9. 01-02-2022 | Tropheryma Whipplei | ReviewPaper

    Rapidly progressive dementia and intractable diarrhea: a teaching case report and a systematic review of cognitive impairment in Whipple’s disease

    The first description of Whipple’s disease (WD), a rare multi-systemic chronic illness caused by Tropheryma whipplei [ 1 ], dates back to 1895 [ 2 ]. In 1907, George Hoyt Whipple described a 36-year-old missionary with malabsorptive syndrome due to …

  10. Open Access 01-12-2020 | Uveitis | OriginalPaper

    Whipple’s disease scleral nodules: a novel presentation in 2 consecutive patients

    Whipple’s disease (WD) is a rare, chronic, multi-organ systemic infection caused by gram-positive or gram-intermediate aerobic filamentous actinobacterium Tropheryma whipplei [ 1 ]. The presentation can be classic, in which gastrointestinal (GI) …

  11. Open Access 01-12-2020 | Tropheryma Whipplei | OriginalPaper

    Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review

    Whipple’s disease (WD) was first described by George Hoyt Whipple in 1907 as an intestinal lipodystrophy [ 1 ]. It is characterized by the histological finding of vacuoles in the macrophages of the intestinal mucous in affected patients [ 2 ]. In …

  12. 01-08-2018 | BriefCommunication

    Whipple’s Disease: Diagnostic Value of rpoB Gene PCR from Peripheral Blood Mononuclear Cells

    The rare systemic chronic infection with Tropheryma whipplei [ 1 ], known as Whipple’s disease (WD), has an estimated incidence of 1:1,000,000 [ 2 , 3 ]. The classical clinical features of WD are polyarthritis, diarrhea, weight loss, and fever [ 2 …

  13. 01-01-2019 | OriginalPaper

    Tropheryma whipplei Infection (Whipple Disease) in the USA

    Classic Whipple disease (WD) is a rare and difficult-to-diagnose infectious disease that often presents as a chronic systemic illness and has been described as diarrhea, weight loss, abdominal pain, and arthralgias in middle-aged men [ 1 – 4 ]. The …

  14. 01-01-2019 | EditorialNotes

    Whipple’s Disease: A Well-Done Outcome to a Rare Disease

    Whipple’s disease (WD) is a condition of which all gastroenterologists likely learn about in medical school, occasionally investigate for, and very rarely see. Despite this rarity, or maybe because of it, there has been a longstanding fascination …

  15. 01-08-2019 | OriginalPaper

    Limbic encephalitis as a relapse of Whipple’s disease with digestive involvement and spondylodiscitis

    Whipple’s disease (WD) is a rare and polymorphic infectious disease due to Tropheryma whipplei (TW), therefore, diagnosis and treatment are often difficult [ 1 ].

  16. 01-09-2003 | OriginalPaper

    Cerebral Whipple’s Disease Diagnosed Using PCR

    The First Case Reported from Greece

    Background: Whipple’s disease (WD) is a rare multisystemic bacterial infection, with variable clinical manifestations occasionally involving the central nervous system. As the cultivation of the etiologic agent, Tropheryma whippelii, is difficult …

  17. 01-05-1998 | OriginalPaper

    Diagnosis and Treatment of Whipple’s Disease

    Whipple’s disease is a rare systemic infectious disease. To date, it has neither been possible to culture the bacillus Tropheryma whippelii, nor to infect other individuals with the pathogen. Today the diagnosis is confirmed by means of polymerase …

  18. 01-05-2019 | OriginalPaper

    Epidemiology of Whipple’s Disease in the USA Between 2012 and 2017: A Population-Based National Study

    Whipple’s disease is a rare infection characterized by arthalgias, weight loss, diarrhea, and abdominal pain caused by the bacteria Tropheryma whipplei [ 1 ] . T. whipplei is ubiquitous in the environment. The bacterium has been detected in sewage …

  19. 01-01-1999 | OriginalPaper

    Whipple’s disease: a rare, insidious disorder with serious consequences

  20. 01-08-2018 | OriginalPaper

    Gamma delta T cell expansion in Whipple’s disease with muscular granulomatous vasculitis

    Whipple’s disease usually presents as chronic joint pain followed by digestive manifestations. However, many different presentations have been described in the literature. We report here the first proven case of muscular vasculitis related to …

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