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1747 search results for:

Leuprolide 

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  1. Open Access 15-09-2023 | Prostate Cancer | OriginalPaper

    Impact of Concomitant Cardiovascular Therapies on Efficacy and Safety of Relugolix vs Leuprolide: Subgroup Analysis from HERO Study in Advanced Prostate Cancer

    Cardiovascular (CV) events are the leading cause of death in patients with prostate cancer, and at least two-thirds of men with prostate cancer are reported as having known CV risk factors, such as obesity, diabetes, hypertension, and …

  2. Open Access 01-12-2020 | Idiopathic Intracranial Hypertension | OriginalPaper

    Pseudotumor cerebri in patient on leuprolide acetate for central precocious puberty

    Central precocious puberty (CPP) refers to premature activation of the hypothalamic–pituitary–gonadal (HPG) axis, resulting in early development of secondary sexual characteristics [ 1 ]. Gonadotropin releasing hormone agonists (GnRHa) are well …

  3. 01-06-2020 | Prostate Cancer | OriginalPaper

    Metabolic changes with degarelix vs leuprolide plus bicalutamide in patients with prostate cancer: a randomized clinical study

    Prostate cancer (PCa) is one of the most common malignancies in men [ 1 ]. Androgen deprivation therapy (ADT) has not only proven to be an effective treatment modality for PCa [ 2 ], but it also induces a negative effect on lipid, glucose, bone …

  4. 01-02-2020 | Electromyographic | OriginalPaper

    Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury

    Constipation, obstructive defecation, and fecal incontinence are known to be frequent complications of spinal cord injury (SCI) [ 1 ]. However, the effects and severity of these complications are not homogeneous and depend on the integration of …

  5. Open Access 01-01-2020 | Prostate Cancer | OriginalPaper

    A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients

    In 2018, the American Cancer Society estimates that prostate cancer is the most frequently diagnosed cancer and the second cause of cancer-related death for men in the US [ 1 ]. In the majority of these cases, the growth, proliferation and survival …

  6. 01-07-2014 | OriginalPaper

    Pharmacokinetic and Exposure–Response Analyses of Leuprolide Following Administration of Leuprolide Acetate 3-Month Depot Formulations to Children with Central Precocious Puberty

    Leuprolide acetate is a potent gonadotropin-releasing hormone (GnRH) agonist that, when administered continuously and in therapeutic doses, acts as a potent inhibitor of gonadotropin secretion. Physiologically, GnRH is secreted in a pulsatile …

  7. 01-04-2015 | OriginalPaper

    Adult height following a combined treatment of ketoconazole — cyproterone acetate — leuprolide depot in a boy with atypical McCune-Albright syndrome

    BACKGROUND: This study was carried out because of the rarity of peripheral precocious puberty (PPP) in boys with McCune-Albright syndrome (MAS) and the lack of data on adult height of treated MAS males, treatment for this disorder being not as yet …

  8. 01-08-2003 | OriginalPaper

    Leuprolide acetate (once-yearly implant): profile report

    A Viewpoint by Judd W. Moul [ 2 ] …

  9. 01-08-2018 | OriginalPaper

    Dienogest Versus Leuprolide Acetate for Recurrent Pelvic Pain Following Laparoscopic Treatment of Endometriosis

    Endometriosis is defined as the presence of ectopic endometrial tissue outside the uterine cavity inducing a chronic inflammatory reaction [ 1 ].

  10. 01-09-2006 | OriginalPaper

    Pituitary apoplexy after leuprolide

    Clinically unsuspected pituitary adenomas are common among adults on autopsy and MRI survey. Acute pituitary hemorrhage is far more rare. We report a case of a 61-year-old male patient with locally advanced prostate cancer who presented with an …

  11. 01-11-1999 | OriginalPaper

    Prevention of rat mammary carcinoma utilizing leuprolide as an equivalent to oophorectomy

    A clinical trial is currently under way to examine the effectiveness of leuprolide as a breast cancer chemopreventive agent and contraceptive. This trial, as well as similar proposed studies, is based on the assumption that leuprolide is as …

  12. 01-01-1998 | OriginalPaper

    Prevention of DMBA-induced rat mammary carcinomas comparing leuprolide, oophorectomy, and tamoxifen

    Leuprolide, a gonadotropin releasing hormone agonist, is currently being evaluated in a pilot study of premenopausal women for the prevention of breast cancer. However, little data is available regarding the efficacy of leuprolide in experimental …

  13. 01-08-2012 | OriginalPaper

    Goserelin versus leuprolide in the chemical castration of patients with prostate cancer

  14. Open Access 01-12-2011 | OriginalPaper

    Leuprolide Acetate 1-Month Depot for Central Precocious Puberty: Hormonal Suppression and Recovery

    Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5–15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback. Forty-nine females <9 years old with …

  15. 01-09-2015 | OriginalPaper

    A Semi-Mechanistic Integrated Pharmacokinetic/Pharmacodynamic Model of the Testosterone Effects of the Gonadotropin-Releasing Hormone Agonist Leuprolide in Prostate Cancer Patients

    Prostate cancer is the second most common cancer and the second leading cause of cancer deaths in men in the USA. Approximately 233,000 new diagnoses and 29,480 prostate cancer deaths are estimated in 2014 [ 1 ]. For patients with metastatic or …

  16. Open Access 01-12-2011 | OriginalPaper

    Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report

    The etiology of myopathy includes congenital disorders, immunologic processes, malignancies, infections, endocrinopathies, alcohol ingestion and adverse drug reactions (particularly statins), immunosuppressive agents, and nucleoside analog reverse …

  17. 01-03-2010 | OriginalPaper

    Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer

    We report the case of a 60 year old male who complained of headache and blurry vision—that progressed to left ophthalmoplegia and ptosis—after receiving a dose of leuprolide for Prostate cancer therapy. Imaging showed a hemorrhagic sellar mass.

  18. 01-03-1999 | OriginalPaper

    Endocrinological and clinical evaluation of two depot formulations of leuprolide acetate in pre- and perimenopausal breast cancer patients

    Purpose: To evaluate the endocrinological and clinical activity of a new slow-release formulation of leuprolide acetate in breast cancer patients. Methods: A total of 50 pre- or perimenopausal patients with early- or late-stage breast cancer who …

  19. 01-09-2014 | Report

    The presence of a pituitary tumor in patients with prostate cancer is not a contraindication for leuprolide therapy

    Gonadotropin (GnRH) agonists such as goserelin (Zoladex, AstraZeneca Pharmaceuticals, Wilmington, DE, USA) and leuprolide (Lupron, Abbot Laboratories, Chicago, IL, USA) are commonly used in the management of patients with primary, recurrent and …

  20. 01-02-1997 | OriginalPaper

    The addition of norethindrone acetate to leuprolide acetate for ovarian suppression has no adverse effect on ovarian stimulation

    Purpose: Our goal was to determine if the addition of norethindrone acetate (NETA) to leuprolide acetate (LA) has an adverse effect on controlled ovarian stimulation (COH) during in vitro fertilization (IVF). Methods: Forty-one consecutive …

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