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Ear Disease 

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  1. 21-05-2024 | Online First

    Progress on early diagnosing Alzheimer’s disease

    Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a continuum, starting with preclinical stages, progressing to mild cognitive and behavioral …

  2. 01-12-2024 | Letter

    Lixisenatide in early parkinson’s disease: efficacy, safety, and future directions: a correspondence

    Parkinson’s disease (PD) presents as a complex neurodegenerative disorder characterized by motor and non-motor symptoms, resulting from dopaminergic neuron degeneration. Current treatment strategies primarily aim to alleviate symptoms through …

  3. Open Access 01-12-2024 | Alzheimer's Disease | OriginalPaper

    Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease

    Alzheimer disease (AD) is a major health problem in older individuals, with tremendous burden on healthcare systems, patients, and families globally [ 1 – 5 ]. Amyloid beta (Aβ) has been identified as having an important role in the pathogenesis of …

  4. 20-05-2024 | Amyloidosis | Online First

    Cardiovascular autonomic failure in hereditary transthyretin amyloidosis and TTR carriers is an early and progressive disease marker

    Hereditary or variant transthyretin amyloidosis (ATTRv amyloidosis) is a multi-systemic disorder characterized by the progressive deposition of extracellular fibrillary misfolded β-sheets amyloid aggregates in various organs and tissues [ 1 ].

  5. 01-06-2024 | Parkinson's Disease | BriefCommunication

    From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

  6. 01-12-2024 | Ureterorenoscopy | OriginalPaper

    Risk factors of early infectious complications after ureterorenoscopy for stone disease: a prospective study

    Retrograde ureterorenoscopy (URS) is an established minimally invasive procedure for the diagnosis and treatment of urolithiasis. Recent review found that infectious complications occur in 0.2% to 15% of cases [ 1 ]. Risk factors included female …

  7. 08-05-2024 | Levodopa | Online First

    The chronic use of serotonin norepinephrine reuptake inhibitors facilitates dyskinesia priming in early Parkinson’s disease

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder featured by motor and non-motor symptoms (NMS). The latter are heterogeneous and have a variable time at onset, anticipating the clinical diagnosis of PD in a large number of …

  8. 15-05-2024 | Chronic Kidney Disease | Online First

    An effective role-oriented binary Walrus Grey Wolf approach for feature selection in early-stage chronic kidney disease detection

    In clinical decision-making for chronic disorders like chronic kidney disease, high variability often leads to uncertainty and negative outcomes. Deep learning techniques have been developed as useful tools for minimizing the chance and improving …

  9. Open Access 01-06-2024 | Chronic Inflammatory Bowel Disease | OriginalPaper

    Very-early-onset Inflammatory Bowel Disease in an Infant with a Partial RIPK1 Deletion

    The monogenic causes of very-early-onset inflammatory bowel disease (VEO-IBD) have been defined by genetic studies, which were usually related to primary immunodeficiencies. Receptor-interacting serine/threonine-protein kinase-1 (RIPK1) protein is …

  10. Open Access 01-12-2024 | Liver Transplantation | OriginalPaper

    NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death

    Progressive familial intrahepatic cholestasis (PFIC) is an ever-growing group of autosomal recessive liver disorders caused by defects in genes associated with bile secretion, bile salt and lipid transporters and regulators [ 1 , 2 ].

  11. Open Access 01-12-2024 | Sildenafil | OriginalPaper

    Sildenafil Versus Placebo for Early Pulmonary Vascular Disease in Scleroderma (SEPVADIS): protocol for a randomized controlled trial

    Pulmonary hypertension (PH) is a hemodynamic condition defined by directly measured pulmonary arterial pressures from right heart catheterization (RHC). Until recently, an individual was considered to have PH when their mean pulmonary artery …

  12. 23-04-2024 | Parkinson's Disease | Online First

    Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease

    Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms [ 1 – 5 ]. Early detection of prodromal symptoms in PD, prior to the onset of evident cardinal motor symptoms, is crucial for …

  13. Open Access 01-12-2024 | Anxiety | OriginalPaper

    Characterization of early markers of disease in the mouse model of mucopolysaccharidosis IIIB

    Mucopolysaccharidosis (MPS) IIIB, also known as Sanfilippo Syndrome B, is a devastating childhood disease caused by a known lysosomal enzyme deficiency [ 1 , 2 ]. Specifically, a complete loss of the lysosomal enzyme alpha-N-acetylglucosaminidase …

  14. Open Access 01-12-2024 | Acute Respiratory Distress-Syndrome | OriginalPaper

    Pulmonary redox imbalance drives early fibroproliferative response in moderate/severe coronavirus disease-19 acute respiratory distress syndrome and impacts long-term lung abnormalities

    Coronavirus disease 2019 (COVID-19) remains a pandemic, with infections and reinfections occurring worldwide [ 1 ]. Despite most patients suffering only mild symptoms, approximately 5–8% of COVID-19 patients evolve into acute respiratory distress …

  15. 08-05-2024 | OriginalPaper

    Blood Level of Nitric Oxide Metabolites and Expression of Genes Regulating NO Synthesis in Early Forms of Non-Alcoholic Fatty Liver Disease

    The levels of NO metabolites in the plasma and mRNA of the NOS3, ATG9B, and NOS2 genes in peripheral blood leukocytes of healthy people and patients with early forms of non-alcoholic fatty liver disease (steatosis and weak activity non-alcoholic …

  16. Open Access 13-04-2024 | Alzheimer's Disease | BriefCommunication

    Amyloid antibody therapy for early-stage Alzheimer’s disease: a critical review of three recent trials

    Pathogenic tau rather than amyloid deposition has been repeatedly reported as a cognitive decline correlate. Monoclonal amyloid-beta antibodies (ABA) target pathological amyloid beta aggregates, one of the multiple proposed drivers of Alzheimer’s …

  17. Open Access 28-02-2024 | Parkinson's Disease | OriginalPaper

    Anatomical correlates of apathy and impulsivity co-occurrence in early Parkinson’s disease

    Neuropsychiatric manifestations of Parkinson’s disease (PD) include a variety of hyperactive and hypoactive behaviors [ 1 ]. One of the most prevalent hyper-active behaviors in PD is impulse control disorders (ICDs), characterized by the inability …

  18. Open Access 01-12-2024 | Chronic Obstructive Lung Disease | OriginalPaper

    Development and application of a deep learning-based comprehensive early diagnostic model for chronic obstructive pulmonary disease

    Chronic obstructive pulmonary disease (COPD), a prevalent and preventable chronic lung ailment, is a well-established risk factor for lung cancer [ 1 – 3 ]. In 2019, COPD resulted in approximately 3.23 million global deaths [ 4 ], with a reported …

  19. Open Access 01-12-2024 | Myocardial Infarction | OriginalPaper

    Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

    Atherosclerotic cardiovascular disease (ASCVD) is a major contributor to the global burden of disease affecting over 523 million people globally [ 1 , 2 ]. Current studies have identified insulin resistance (IR) is one of the most important risk …

  20. Open Access 01-12-2024 | Pathology | OriginalPaper

    Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

    The cholinergic hypothesis of AD states that selective loss of cholinergic neurons, arising from basal forebrain nuclei, and decreased levels of the neurotransmitter, acetylcholine (ACh), trigger neurodegeneration and cognitive impairment [ 1 ].

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