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Dying Phase 

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  1. Open Access 01-12-2022 | Care | OriginalPaper

    Dying in hospital in Germany – optimising care in the dying phase: study protocol for a multi-centre bottom-up intervention on ward level

    A significant proportion of the population in developed countries dies in hospitals, making them important places of care at the end of life [ 1 ]. Even though most patients wish to die at home [ 1 , 2 ], the percentage of hospital deaths ranges …

  2. 01-05-2021 | Care | OriginalPaper

    Differences in aggressive treatments during the actively dying phase in patients with cancer and heart disease: an exploratory study using the sampling dataset of the National Database of Health Insurance Claims

    Despite the recent attention given to palliative care for patients with heart disease, data about the treatments in their actively dying phase are not sufficiently elaborated. In this study, we used the sampling dataset of a national database to …

  3. Open Access 01-12-2016 | OriginalPaper

    Development of a complex intervention to support the initiation of advance care planning by general practitioners in patients at risk of deteriorating or dying: a phase 0-1 study

    Many patients receive inappropriate or futile care at the end of life and this mostly results from a mismatch between the needs of patients and the norms of current practice [ 1 ]. A possible response to this concern is advance care planning, as it …

  4. 01-08-2009 | Abstract

    Multiple organ dysfunction syndrome: the scapegoat? Assessment of organ dysfunction between surviving and dying mice in the acute phase of polymicrobial sepsis

    Multiple organ dysfunction syndrome (MODS) frequently complicates sepsis contributing to poor outcome. Yet the evolution of MODS in the early septic mortality (ESM) is unclear. To delineate the ESM-MODS relationship, we compared the development …

  5. Open Access 23-03-2023 | SARS-CoV-2 | OriginalPaper

    Specialized palliative care for hospitalized patients with SARS-CoV-2 infection: an analysis of the LEOSS registry

    Severe manifestations of SARS-CoV-2 predominantly affect older and frail people as well as those with chronic conditions, leading to hospitalization and life-threatening disease particularly in patients with comorbidities. Managing these patients …

  6. Open Access 01-12-2022 | Care | OriginalPaper

    End-of-life care for people with dementia on a green care farm during the COVID-19 pandemic: a qualitative study

    Previous studies have already investigated about the end-of-life care for people with dementia in nursing homes. Previous studies indicated that they were positive about life on a care farm for people with dementia.

  7. Open Access 01-12-2024 | OriginalPaper

    Barriers and drivers of public engagement in palliative care, Scoping review

    Society, professionals and healthcare systems are heavily focused on treating illnesses, and sometimes can lose focus on the inevitability of death [ 1 ]. Current models of end-of-life care are being questioned because of their excessive …

  8. Open Access 01-12-2024 | OriginalPaper

    Rural healthcare professionals’ participation in Medical Assistance in Dying (MAiD): beyond a binary decision

    The following section describes the context of the health zone in Alberta Canada where MAiD provisions are allowed and in which this study was conducted. We provide a description of rural practice since our focus is on rural HCPs’ experiences …

  9. Open Access 14-05-2024 | Online First

    Standardizing Integrated Oncology and Palliative Care Across Service Levels: Challenges in Demonstrating Effects in a Prospective Controlled Intervention Trial

    Modern palliative care (PC) is an important part of oncology, and early introduction is recommended in conjunction with anticancer therapy [ 1 – 3 ]. PC can be delivered in a variety of settings, including inpatient units, outpatient clinics …

  10. 01-06-2006 | OriginalPaper

    Joint application of independent component analysis and non-stationary fluctuation analysis for studying the mechanisms of the early phase of long-term potentiation in the rat hippocampus

    Interest in studies of synaptic plasticity have led to the development of specific methods for analyzing evoked postsynaptic currents: quantum analysis, component analysis, non-stationary fluctuation analysis, etc. However, the use and …

  11. 01-04-2002 | OriginalPaper

    Long-Term Follow-Up of a Phase II Trial Studying a Weekly Doxorubicin-Based Multiple Drug Adjuvant Therapy for Stage II Node-Positive Carcinoma of the Breast

    Background. Combination chemotherapy improves outcomes in women with breast cancer (BC) that involves axillary nodes. This single-arm study aimed to evaluate the effectiveness of an intensive doxorubicin-based multi-drug regimen as adjuvant …

  12. Open Access 01-12-2024 | COVID-19 | OriginalPaper

    Care fragmentation and readmission mortality and length of stay before and during the COVID-19 pandemic: data from the National Readmissions Database, 2018–2020

    When a patient is readmitted to a different hospital than they were previously discharged from, interhospital fragmentation of care occurs. These fragmented readmissions account for around 25% of all 30-day readmissions [ 1 – 3 ] and are associated …

  13. Open Access 01-12-2024 | Fertility | OriginalPaper

    Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation

    Only a competent oocyte that is viable, mature, and euploid can make a healthy baby [ 1 ]. Dying and dead oocytes do not develop. Immature oocytes cannot be fertilized, and aneuploid oocytes usually do not implant, survive, or make healthy …

  14. Open Access 01-12-2024 | OriginalPaper

    What helps or hinders effective end-of-life care in adult intensive care units in Middle Eastern countries? A systematic review

    Globally, the majority of people with chronic diseases such as cardiovascular diseases, chronic respiratory diseases, kidney failure, and cancer require special care at the end-of-life (EOL) phase when their health worsens before death [ 1 , 2 ].

  15. Open Access 01-12-2024 | OriginalPaper

    Anticipatory prescribing of injectable controlled drugs (ICDs) in care homes: a qualitative observational study of staff role, uncertain dying and hospital transfer at the end-of-life

    Older adults, their carers, and clinicians may experience significant anguish as a result of poorly managed symptoms in the last days of life [ 1 – 4 ]. The prescription of injectable controlled drugs (ICDs) ahead of potential need has become a key …

  16. Open Access 01-12-2024 | OriginalPaper

    The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells

    Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis and become malignant polyploid giant …

  17. Open Access 01-12-2024 | OriginalPaper

    Nurse assistants’ perception of caring for older persons who are dying in their own home

    An interview study

    The number of older persons worldwide is increasing rapidly, with its population projected to rise from 10% in 2022 to 16% in 2050 [ 1 ]. According to the World Health Organization (WHO) [ 2 ], an estimated 56.8 million people, including 25.7 …

  18. Open Access 28-03-2024 | OriginalPaper

    Palliative care for patients with hematologic malignancies in Germany: a nationwide survey on everyday practice and influencing factors from the perspective of treating physicians

    Integrating palliative care into the treatment of patients with advanced hematological malignancies (HM) remains challenging. To explore treating physicians’ perspectives on current palliative care practice and to evaluate factors influencing …

  19. Open Access 01-12-2024 | Palliative Care Unit | OriginalPaper

    When dying does not go well: a qualitative study

    In recent decades, research on the concept of a good death (a better term would be "dying well") has been conducted repeatedly, often supported by qualitative and quantitative methods [ 1 – 3 ]. Such studies attempt to establish a plausible …

  20. Open Access 01-12-2024 | OriginalPaper

    Facilitators and barriers of implementing end-of-life care volunteering in a hospital in five European countries: the iLIVE study

    Over the past years, end-of-life (EoL) care volunteering has become an important contribution to high quality care for patients in their last phase of life [ 1 ]. EoL care volunteers have been shown to offer practical, emotional, social, and …

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